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moutan cortex and Paeoniae Radix Rubra reverse high-fat-diet-induced metabolic disorder and restore gut microbiota homeostasis

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Chinese Journal of Natural Medicines 2017年第3期15卷 210-219页

作者： ZHONG Ling-Jun XIE Zhi-Sheng YANG Hua LI Ping XU Xiao-Jun State Key Laboratory of Natural Medicines China Pharmaceutical UniversityNanjing 210009China Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases China Pharmaceutical UniversityNanjing 210009China

The present study was designed to investigate the therapeutic effcts of moutan cortex(CM,root bark of Paeonia suffruticosa Andr) and Paeoniae Radix Rubra(PR,root of Paeonia veitchii Lynch) on metabolic disorders,focusing on the infuence of CM and PR on the obesity-related gut microbiota *** diet-induced obese(DIO) mouse model was used to test the therapeutic effects of CM and *** mice were orally administered with CM and PR for 6 weeks,and oral glucose tolerance test(OGTT) and insulin tolerance test(ITT) were performed to evaluate the insulin sensitivity of the ***-regulatory element binding proteins(SREBPs) and their target genes were measured by quantitative ***-throughput 16 S ribosomal RNA(16S rR NA) gene sequencing technology was used to determine the composition of gut microbiota,and the metabolites in serum were analyzed by *** results indicated that CM and PR combination alleviated obese and insulin resistance in the DIO mice,leading to increased glucose uptake and gene expression in muscle and liver,and down-regulated SREBPs and their target genes in ***,neither the CM-PR extracts,nor the major components of CM and PR did not affect SREBPs activity in cultured ***,CM and PR significantly modulated the gut microbiota of the high-fat diet(HFD) treated mice,similar to metformin,and CM-PR reversed the overall microbiota composition similar to the normal chow diet(NCD) treated *** conclusion,our results provide novel mechanisms of action for the effects of CM and PR in treating DIO-induced dysregulation of sugar and lipid metabolism.

关键词： moutan cortex Paeoniae Radix Rubra Insulin resistance Gut microbiota

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A precise and specific method for quick determination of sulfur fumigation for moutan cortex

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World Journal of Traditional Chinese Medicine 2017年第1期3卷 16-21页

作者： Na Hu Juan Da Xin Chen Shang-Rong Li Qiu-Rong Wang Ting-Ting Wu Lin Yang Wan-Ying Wu De-an Guo Changchun University of Chinese Medicine Shanghai Research Center for Modernization of Traditional Chinese Medicine National Engineering Laboratory for TCM Standardization TechnologyShanghai Institute of Materia Medica Chinese Academy of Sciences

Objective: Establish a quick, precise and specific method to determine whether the moutan cortex obtained from market is processed with sulfur; provide a reliable method for the scientific ***: Three methods, including acid-base titration method, high-performance liquid-chromatography(HPLC) method, and ultraperformance liquid chromatography coupled with time-of-flight mass spectrometry(UHPLC-TOF-MS) method were used to detect whether30 batches of samples were fumigated with ***: The results of three methods were substantially the same. Fifteen batches were identified to have been processed with sulfur fumigation, while others were ***: The HPLC method was found to be most appropriate for the determination of sulfur fumigation for moutan cortex.

关键词： moutan cortex Sulfur fumigation Paeoniflorin Paeoniflorin sulfonate HPLC method

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