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Curcumin Inhibits Prostate Cancer Bone Metastasis by Up-Regulating Bone morphogenic Protein-7 <i>in Vivo</i>

Journal of Cancer Therapy 2014年第4期5卷 369-386页

作者： Thambi Dorai Janane Diouri Orla O’Shea Stephen B. Doty Analytical Microscopy Laboratory Hospital for Special Surgery New York USA Department of Urology New York Medical College Valhalla USA

A number of studies have focused on the beneficial properties of Curcumin (diferuloyl methane, used in South Asian cuisine and traditional medicine) such as the chemoprevention of cancer. Recent studies have also indicated that this material has significant benefits for the treatment of cancer and is currently undergoing several clinical trials. We have been interested in the application of this compound as a therapeutic agent for advanced prostate cancer, particularly the skeletal complications in this malignancy. Our earlier work indicated that this compound could inhibit the osteomimetic properties which occur in castration resistant prostate cancer cells, by interfering with the common denominators between these cancer cells and the bone cells in the metastatic tumor microenvironment, namely the osteoblasts and the osteoclast. We predicted that curcumin could break the vicious cycle of reciprocal stimulation that results in uncontrolled osteolysis in the bony matrix. In this work, we have evaluated the potential of this compound in inhibiting the bone metastasis of hormone refractory prostate cancer cells in an established animal model. Our results strongly suggest that curcumin modulates the TGF-βsignaling that occurs due to bone matrix degradation by up-regulating the metastasis inhibitory bone morphogenic protein-7 (BMP-7). This enhancement of BMP-7 in the context of TGF-β in the tumor microenvironment is shown to enhance the mesenchymal-to-epithelial transition. Most importantly, we show that as a result of BMP-7 up-regulation, a novel brown/beige adipogenic differentiation program is also up-regulated which plays a role in the inhibition of bone metastasis. Our results suggest that curcumin may subvert the TGF-β signaling to an alternative adipogenic differentiation program in addition to the previously established interference with the osteomimetic properties, thus inhibiting the bone metastatic processes in a chemopreventive as well as therapeutic setting

关键词： Curcumin Osteomimetic Properties Bone Metastasis Bone morphogenic Protein-7 TGF-β Prostate Cancer Tumor Microenvironment

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Alginate encapsulation in Glycyrrhiza glabra *** phyto-chemical profiling of root extracts of in vitro converted plants using GC-MS analysis

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Asian Pacific Journal of Tropical Biomedicine 2017年第10期7卷 855-861页

作者： Rakhshanda Akhtar Anwar Shahzad Plant Biotechnology Section Department of BotanyAligarh Muslim UniversityAligarh 202002Uttar PradeshIndia

Objective: To investigate the conversion potential of alginate encapsulated nodes of Glycyrrhiza glabra with phyto-chemical evaluation of root extract of field transferred ***: The excised axenic nodal segments were encapsulated in alginate matrix planted on Murashige and Skoog(1962) medium with different supplementation and formulations of PGRs. The two year old field transferred plants were evaluated for phytocompounds analysis using GC-MS ***: Varied responses were observed during the study, maximum conversion95.83% ± 2.40% was obtained in these encapsulates when planted on MS medium containing 2.5 m M Kinetin and 0.5 m M a-Naphthalene acetic acid, which eventually developed into complete plantlets in a single step. Further, GC-MS analysis showed the presence of different phyto-compounds in the methanolic root extracts of in vitro converted plants. The results obtained revealed the presence of about 47 phyto-compounds along with various potential bioactive compounds useful for industrial and pharmaceutical ***: This study investigates high frequency regeneration and conversion of Glycyrrhiza glabra in a single step in short time. Also, the in vitro raised plants are analysed for bioactive compounds after field transfer, which shows the presence of numerous compounds useful for commercial and pharmacological purposes.

关键词： Synseeds Conservation Licorice morphogenic Chemopreventive

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High Frequency Plant Regeneration from Leaf Derived Callus of <i>Dianthus caryophyllus</i>L.

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American Journal of Plant Sciences 2014年第15期5卷 2454-2463页

作者： Muhammad Arif Saima Rauf Aziz Ud Din Mamoona Rauf Humera Afrasiab Department of Botany University of the Punjab Quaid-e-Azam Campus Lahore Pakistan Department of Genetics Hazara University Garden Campus Mansehra Pakistan Institute of Agricultural Sciences University of the Punjab Lahore Pakistan National Institute for Biotechnology and Genetic Engineering Faisalabad Pakistan

An efficient procedure was developed for in vitro callus induction, proliferation and regeneration of carnation cultivar (Dianthus caryophyllus L.) using leaf, nodal and inter-nodal explants on Murashige and Skoog’s medium (MS) supplemented with exogenous plant growth regulators. For morphogenic callus induction and proliferation from various explants, MS medium supplemented with 3.0 mg/l 2,4-D was highly efficient with 100% callus induction frequency from inter-nodal explants. Leaf explants showed quicker response than nodal and inter-modal explants, for callus initiation within 6 days of inoculation. Best grown callus was obtained from leaf explant. The leaf-derived callus was maintained up to several weeks, which indicated that 8-week incubation period was the most suitable for obtaining well proliferated, morphogenic callus. Temperature variation also affected the growth of in vitro induced morphogenic callus from various explants. Results have shown that 27°C proved to be the best temperature for morphogenic callus induction and proliferation from leaf and inter-nodal explants. Among the auxin-cytokinin combination, MS medium containing 1.0 mg/l N(6)-benzylaminopurin (BAP) and 2.0 mg/l NAA showed the highest efficiency of callus initiation and proliferation from leaf, nodal and inter-nodal explants. Light conditions proved better for callogenesis and proliferation from leaf, nodal and inter-nodal explants. Regeneration response from well grown morphogenic callus was prominent on MS medium supplemented with 3.0 mg/l BAP alone and 1.0 mg/l NAA with 3.0 mg/l BAP.

关键词： Dianthus caryophyllus L. Regeneration Potential Plant Growth Regulators morphogenic Callus Induction

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