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morin enhances hepatic Nrf2 expression in a liver fibrosis rat model

World Journal of Gastroenterology 2017年第47期23卷 8334-8344页

作者： Liang Sang Xue-Mei Wang Dong-Yang Xu Li-Xuan Sang Yang Han Long-Yang Jiang Department of Ultrasound The First Hospital of China Medical UniversityShenyang Department of Geriatrics The First Hospital of China Medical UniversityShenyang Department of Pathology China Medical UniversityShenyang Pharmacy College China Medical UniversityShenyang

AIM To investigate whether morin can reduce hepatic fibrosis by activating the NF-E2-related factor 2(Nrf2) signaling *** Twenty male Sprague-Dawley rats were randomly divided into four groups: control group, morin group, carbon tetrachloride(CCl4) group, and morin + CCl4 group. Rats in both the CCl4 and morin + CCl4 groups were injected intraperitoneally with CCl4 at a dose of 2 mL/kg twice a week. Rats in both the morin and morin + CCl4 groups were treated orally with morin at a dose of 50 mg/kg twice a week. Control rats were treated with vehicle only twice a week. At the end-point of the 8 wk of the experimental period, serum AST, ALT, and ALP were measured, and the liver specimenswere obtained for pathological assessment. Real-time PCR and Western blot methods were used to analyze the expression of α-smooth muscle actin(α-SMA), collagen Ⅰ, collagen Ⅲ, Nrf2, heme oxygenase(HO-1), and quinone oxidoreductase 1(NQO1) using frozen liver *** morin-treated rats in the morin + CCl4 group had less hyperplasia of fiber tissue, minimal inflammatory cells, and less body weight loss with favorable liver enzyme measurements compared to rats treated with CCl4 only. Additionally, morin-treated rats had significantly lower m RNA and protein expression of α-SMA, collagen Ⅰ, and collagen Ⅲ, but significantly higher m RNA and protein expression of Nrf2, HO-1, and NQO1 compared to rats treated with CCl4 only(P morin could play a protective role by inducing the expression of Nrf2 and its downstream antioxidant factors(HO-1 and NQO1) and reducing the expression of α-SMA, collagen Ⅰ, and collagen Ⅲ in CCl4-induced liver fibrosis rats.

关键词： Liver fibrosis Rat morin Nrf2

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morin, a matrix metalloproteinase 9 inhibitor, attenuates endothelial-to-mesenchymal transition in atherosclerosis by downregulating Notch-1 signaling

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Journal of Integrative Medicine 2024年第6期22卷 683-695页

作者： Yuan He Xiao-xuan Qin Ming-wei Liu Wei Sun Department of Cardiology Jiangsu Provincial People's Hospital Nanjing Medical University Department of Neurology Jiangsu Provincial People's Hospital Nanjing Medical University

Objective: Atherosclerotic cardiovascular disease poses a significant health challenge globally. Recent findings highlight the pivotal role of the endothelial-to-mesenchymal transition(End MT) in atherosclerosis. morin is a bioflavonoid mainly extracted from white mulberry, a traditional Chinese herbal medicine with anti-inflammatory and antioxidant properties. This study examines whether morin can alleviate atherosclerosis by suppressing End MT and seeks to elucidate the underlying ***: We induced an in vitro End MT model in human umbilical vein endothelial cells(HUVECs) by stimulating the cells with transforming growth factor-β1(TGF-β1)(10 ng/m L) for 48 h. The in vivo experiments were performed in an atherosclerosis model using apolipoprotein E(Apo E)–/–mice fed with a high-fat diet(HFD). Mice in the intervention group were given morin(50 mg/kg) orally for 4 *** docking and microscale thermophoresis were assayed to understand the interactions between morin and matrix metalloproteinase-9(MMP-9).Results: morin inhibited the expression of End MT markers in a dose-dependent manner in TGF-β1-treated HUVECs. Administering 50 μmol/L morin suppressed the upregulation of MMP-9 and Notch-1 signaling in TGF-β1-induced End MT. Moreover, the overexpression of MMP-9 activated Notch-1 signaling,thereby reversing morin's inhibitory effect on End MT. In the HFD-induced atherosclerotic Apo E–/–mice,morin notably reduced aortic intimal hyperplasia and plaque formation by suppressing End ***, morin demonstrated a strong binding affinity for ***: morin acts as an MMP-9 inhibitor to disrupt End MT in atherosclerosis by limiting the activation of Notch-1 signaling. This study underscores morin's potential utility in the development of antiatherosclerotic medication.

关键词： morin Endothelial-to-mesenchymal transition Atherosclerosis Traditional Chinese medicine Matrix metalloproteinase-9

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morin attenuates L-arginine induced acute pancreatitis in rats by downregulating myeloperoxidase and lipid peroxidation

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Asian Pacific Journal of Tropical Biomedicine 2021年第4期11卷 148-154页

作者： Kanwal Rehman Ummara Rashid Komal Jabeen Muhammad Sajid Hamid Akash Department of Pharmacy University of AgricultureFaisalabadPakistan Institute of Physiology and Pharmacology University of AgricultureFaisalabadPakistan Department of Pharmaceutical Chemistry Government College University FaisalabadPakistan

Objective:To explore the therapeutic role of morin against L-arginine-induced acute pancreatitis in ***:The group 1 received two intraperitoneal injections of normal saline,and groups 2-4 were given two intraperitoneal injections of L-arginine(250 mg/100 g body weight)at 1 h interval to induce acute ***,group 2 received no further treatment while groups 3 and 4 were treated with morin(30 mg/kg)and diclofenac sodium(30 mg/kg),*** glucose and serum levels of insulin,α-amylase,malondialdehyde,myeloperoxidase,alanine aminotransferase,aspartate aminotransferase and cholesterol were ***,histopathological study was carried out to investigate the effect of morin treatment on physiology of the ***:L-arginine significantly altered the level of blood glucose and serum levels of insulin,α-amylase,malondialdehyde,myeloperoxidase,alanine aminotransferase,aspartate aminotransferase and *** with morin or diclofenac sodium significantly improved the levels of these ***,morin showed more significant effect than diclofenac *** analysis verified that morin protected the pancreas from deleterious effects of ***:morin plays a protective role against L-arginineinduced acute pancreatitis via reducing lipid peroxidation and tissue inflammation,and attenuating acute pancreatitis-associated alteration in insulin secretion and glucose metabolism.

关键词： morin Acute pancreatitis Diclofenac sodium L-arginine

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Anti-epileptic effect of morin against experimental pentylenetetrazol-induced seizures via modulating brain monoamines and oxidative stress

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Asian Pacific Journal of Tropical Biomedicine 2018年第7期8卷 352-359页

作者： Amit D.Kandhare Anwesha A.Mukherjee Subhash L.Bodhankar Department of Pharmacology Poona College of Pharmacy Bharati Vidyapeeth Deemed University

Objective: To evaluate the protective effect of morin against pentylenetetrazol(PTZ)-induced tonic-clonic convulsions in mice. Methods: Swiss albino mice(18-22 g) was used to induce convulsions by intraperitoneal(i.p.) administration of PTZ(90 mg/kg). Mice were either pretreated with morin(10, 20 and 40 mg/kg) or vehicle(distilled water, 10 mg/kg) 45 min before PTZ administration. Various behavioral and biochemical parameters were assessed. Results: PTZ administration resulted in significant production(Pmorin(20 and 40 mg/kg) administration. The PTZinduced decrease in brain GABA, dopamine and Na+K+ATPase levels and increase in xanthine oxidase activity were inhibited significantly by morin(20 and 40 mg/kg) treatment. The increased levels of malondialdehyde and nitric oxide level were significantly decreased by morin(20 and 40 mg/kg) treatment. Also, reduced levels of superoxide dismutase and glutathione were increased significantly by morin treatment. Conclusions: Results of the present study indicate that morin showed its anti-convulsant effect via modulating the levels of brain GABA, Na^+K^+ATPase, and oxido-nitrosative stress. Thus, morin can be a potential candidate for further clinical evaluations as an anti-epileptic agent.

关键词： Brain GABA Epilepsy morin Nitric oxide Pentylenetetrazol Oxidative stress Xanthine oxidase

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The change of morin transition temperature in nanocrystalline α-Fe_2O_3

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Chinese Science Bulletin 1997年第4期42卷 344-346页

作者： LI Haibo, GONG Jie, ZHENG Weitao, CHEN Gang and YU Ruihuang1. Department of Materials Science, Jilin University, Changchun 130023, China 2 Department of Physics, Siping Normal ( lege, Siping 136000, China Department of Materials Science Jilin University Changchun China Department of Physics Siping Normal College Siping China

THE magnetic property of the ultrafine particles differs from that ot the bulk materials and has a lot of applications. Because of the size effect, magnetically ordered materials exhibit both superparamagnetism and collective magnetic excitation, and the magnetic transition temperature changes in the ultrafine particles with respect to the bulk materials as well. Bulk α-Fe2O3 is weakly ferromagnetic above the morin transition temperature TM

关键词： morin transition ultrafine particles Mossbauer effect.

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STUDY ON THE ADSORPTIVE COMPLEX WAVE OF RARE EARTH IONS WITH morin

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Chinese Science Bulletin 1992年第15期37卷 1269-1273页

作者：徐友宣李南强 Department of Chemistry Peking University Bering 100871 PRC

Ⅰ. INTRODUCTIONBy using extraction-spectrophotometry or extraction-fluorophotometry, some methods were utilized to study the complexes of rare earth ions with morin (MOR). The authors propose that the rare earth ions... 详细信息

关键词： rare earth morin single-sweep polarography.

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A validated HPTLC method for quantitative analysis of morin in Maclura cochinchinensis heartwood

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Chinese Herbal Medicines 2020年第2期12卷 200-203页

作者： Savita Chewchinda Sumet Kongkiatpaiboon Department of Food Chemistry Faculty of PharmacyMahidol UniversityBangkok 10400Thailand Drug Discovery and Development Center Office of Advanced Science and TechnologyThammasat University(Rangsit Campus)Pathum Thani 12121Thailand

Objective:The study was conducted to develop and validate a high performance thin-layer chromatography(HPTLC)-densitometric method for the quantitative analysis of morin in Maclura cochinchinensis heartwood collected from different locations in ***:HPTLC analysis was performed on an aluminium sheet of silica gel 60 F254 using toluene:ethyl acetate:formic acid(36:12:7,volume percent)as a mobile *** densitometric scanning was performed at the wavelength 410 *** method was validated according to ICH ***:The proposed HPTLC method showed acceptable validation *** content of morin in *** heartwood collected from eight different provinces in Thailand were in the ranges of1.53%-2.73%.Conclusion:The simple and sensitive HPTLC method was successfully developed and validated for determination of morin in *** *** proposed HPTLC method was found to be simple,fast and inexpensive,and can be used for the routine quality control of raw materials.

关键词： HPTLC Maclura cochinchinensis(Lour.)Corner morin

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Effect of morin, a flavonoid against DOCA-salt hypertensive rats:a dose dependent study

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Asian Pacific Journal of Tropical Biomedicine 2012年第6期2卷 443-448页

作者： Prahalathan P Kumar S Raja B Department of Biochemistry and Biotechnology Faculty of Science Annamalai University

Objective:To determine the protective effect of morin, a flavonoid against deoxycorticosterone acetate(DOCA)-salt induced hypertension in male Wistar ***:Hypertension was induced in uninephrectomized rats by weekly twice subcutaneous injection of DOCA(25 mg/kg bw) and 1% NaCl in the drinking water for six consecutive weeks. Effect of morin against DOCA-salt induced hypertension was evaluated by measuring blood pressure and performing biochemical estimations and histopathological examination of renal ***:DOCA-salt hypertensive rats showed considerably increased systolic and diastolic blood pressure,serum hepatic marker enzyme activities such as aspartate aminotransferase(AST), alanine aminotransferase(ALT), alkaline phosphatase(ALP) and gamma-glutamyl transpeptidase(GGT)and renal function markers(urea, uric acid and creatinine) in plasma. Oral administration of morin(25, 50 and 75 mg/kg bw) brought back all the above parameters to near normal *** of kidney also confirmed the biochemical findings of this study. The effect at a dose of 50 mg/kg bw of morin was more pronounced than that of the other two doses(25 and 75 mg/kg bw).Conclusions:These findings indicate that morin exhibits strong antihypertensive effect against DOCA-salt induced hypertension.

关键词： morin Uninephrectomy DOCA-salt Oxidative stress Hypertension Antihypertensive effect Blood pressure

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Synthesis and Characterization of Fe<sub>3</sub>O<sub>4</sub>Coated on APTES as Carriers for morin-Anticancer Drug

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Journal of Biomaterials and Nanobiotechnology 2015年第4期6卷 267-275页

作者： Bassam Saif Congli Wang Dong Chuan Shaomin Shuang School of Chemistry and Chemical Engineering Shanxi University Taiyuan China Research Center of Environmental Science and Engineering Shanxi University Taiyuan China

morin (MR) is an anticancer drug present in fruits and Chinese herbs. Fe3O4 magnetic nanoparticles (MNPs) coated on 3-aminopropyl triethoxysilane (APTES) were synthesized (MNPs-APTES) as carriers for MR. The characterization of drug delivery system was confirmed by Fourier Transform Infrared (FTIR), Transmission Electron Microscope (TEM), X-Ray Diffraction (XRD), dynamic light scattering (DLS), and vibrating sample magnetometer (VSM). The adsorbed APTES on the magnetite surface (MNPs-APTES) was examined by FTIR. The TEM image showed that the average particle size is obtained to be about 26.7 nm for MNPs-APTES. The MR loading and release behavior of MNPs-APTES were studied and the results showed that up to 60% of the adsorbed drug was released within 4 h. In summary, the MNPs-APTES nanocarriers are based on the results, promising for targeted morin drug delivery.

关键词： Magnetic Nanoparticles Drug Delivery Flavonoid morin

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Investigation of the interaction between morin and DNA

Investigation of the interaction between morin and DNA

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中国化学会第十五届全国化学热力学和热分析学术会议

作者： Lin Wu Chao-Hui Chen Li Lin Yan-Jun Hu~* Hubei Key Laboratory of Pollutant Analysis & Reuse Technology Department of Chemistry Hubei Normal University Huangshi 435002 PR China

＜正＞In this work we investigation of the interaction between morin（MR） and DNA,including the structure,the characteristics and the physiology function of DNA and its application in all aspects. The interaction of ... 详细信息

关键词： morin Ethidium bromide hs-DNA Spectroscopic method

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