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World Journal of Psychiatry 2022年第3期12卷 379-392页

作者： Xiao-Pei Zhao Hui Li Ru-Ping Dai Department of Anesthesiology The Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina

mood disorders are the most common mental disorders, affecting approximately350 million people globally. Recent studies have shown that neuroimmuneinteraction regulates mood disorders. Brain-derived neurotrophic factor (BDNF)and its precursor pro-BDNF, are involved in the neuroimmune crosstalk duringthe development of mood disorders. BDNF is implicated in the pathophysiologyof psychiatric and neurological disorders especially in antidepressant *** this review, we describe the functions of BDNF/pro-BDNF signalingin the central nervous system in the context of mood disorders. In addition, wesummarize the developments for BDNF and pro-BDNF functions in mooddisorders. This review aims to provide new insights into the impact ofneuroimmune interaction on mood disorders and reveal a new basis for furtherdevelopment of diagnostic targets and mood disorders.

关键词： Brain-derived neurotrophic factor pro-BDNF Neural circuits Neuroimmune mood disorders Depression

Hypomanic/manic switch after transcranial magnetic stimulation in mood disorders:A systematic review and meta-analysis

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World Journal of Psychiatry 2021年第8期11卷 477-490页

作者： Andrea Miuli Gianna Sepede Gianfranco Stigliano Alessio Mosca Francesco Di Carlo Giacomo d’Andrea Aliseo Lalli Maria Chiara Spano Mauro Pettorruso Giovanni Martinotti Massimo Di Giannantonio Department of Neuroscience Imaging and Clinical Sciences“G.d'Annunzio”University of ChietiChieti 66100Italy Department of Psychiatry Affective Neuropsychiatry Sahlgrenska University HospitalGöteborg 40530Sweden Department of Pharmacy Clinical ScienceUniversity of HertfordshireHerts AL109ABItaly

BACKGROUND Nowadays there is an increasing use of transcranial magnetic stimulation(TMS)both in neurological and psychiatric *** Food and Drug Administration approval of TMS for the therapy of treatment-resistant depression,TMS has been widely used in the context of mood disorders(MD).However,growing reports regarding the possibility of developing hypomanic/manic switch(HMS)have generated concern regarding its use in *** To investigate the actual risk of developing HMS due to TMS in the treatment of *** We led our research on PubMed,Scopus and Web of Science on March 22,2020,in accordance to the PRISMA guidelines for systematic *** double blind/single blind studies,written in English and focused on the TMS treatment of MD,were included.A meta-analysis of repetitive TMS protocol studies including HMS was conducted using RevMan 5.4 *** assessment of Risk of Bias was done using Cochrane risk of bias *** protocol was registered on PROSPERO with the CRD42020175811 *** Twenty-five studies were included in our meta-analysis:Twenty-one double blind randomized controlled trials(RCT)and four single blind-RCT(*** subjects involved in active stimulation=576;*** subjects involved in sham protocol=487).The most frequently treated pathology was major depressive episode/major depressive disorder,followed by resistant depression,bipolar depression and other *** majority of the studies used a repetitive TMS protocol,and the left dorsolateral prefrontal cortex was the main target *** effects were reported in eight studies and HMS(described as greater energy,insomnia,irritability,anxiety,suicidal attempt)in four *** comparing active TMS vs sham treatment,the risk of developing HMS was not significantly different between *** Applying the most usual protocols and the appropriate precautionary measures,TMS seems not to be related to HMS development.

关键词： Hypomanic/manic switch Transcranial magnetic stimulation Active vs sham comparison mood disorders Adverse event Safety

False dogmas in mood disorders research:Towards a nomothetic network approach

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World Journal of Psychiatry 2022年第5期12卷 651-667页

作者： Michael HJ Maes Drozdstoy Stoyanov Department of Psychiatry Chulalongkorn UniversityBangkok 10330Thailand Department of Psychiatry Medical University PlovdivPlovdiv 4000Bulgaria

The current understanding of major depressive disorder(MDD)and bipolar disorder(BD)is plagued by a cacophony of controversies as evidenced by competing schools to understand MDD/*** DSM/ICD taxonomies have cemented their status as the gold standard for diagnosing MDD/*** aim of this review is to discuss the false dogmas that reign in current MDD/BD research with respect to the new,data-driven,machine learning method to model psychiatric illness,namely nomothetic network psychiatry(NNP).This review discusses many false dogmas including:MDD/BD are mind-brain disorders that are best conceptualized using a bio-psycho-social model or mind-brain interactions;mood disorders due to medical disease are attributable to psychosocial stress or chemical imbalances;DSM/ICD are the gold standards to make the MDD/BD diagnosis;severity of illness should be measured using rating scales;clinical remission should be defined using threshold values on rating scale scores;existing diagnostic BD boundaries are too restrictive;and mood disorder spectra are the *** contrast,our NNP models show that MDD/BD are not mind-brain or psycho-social but systemic medical disorders;the DSM/ICD taxonomies are counterproductive;a shared core,namely the reoccurrence of illness(ROI),underpins the intertwined recurrence of depressive and manic episodes and suicidal behaviors;mood disorders should be ROI-defined;ROI mediates the effects of nitro-oxidative stress pathways and early lifetime trauma on the phenome of mood disorders;severity of illness and treatment response should be delineated using the NNP-derived causome,pathway,ROI and integrated phenome scores;and MDD and BD are the same illness.

关键词： Nomothetic network psychiatry Depression mood disorders Affective disorders Inflammation Oxidative and nitrosative stress Neuro-immune

Psychotic and nonpsychotic mood disorders in autoimmune encephalitis:diagnostic issues and research implications

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Neuroimmunology and Neuroinflammation 2015年第1期2卷 228-236页

作者： Giuseppe Quaranta Nunzio Bucci Cristina Toni Giulio Perugi Department of Experimental and Clinic Medicine Section of PsychiatryUniversity of Pisa56100 PisaItaly Department of Mental Health Health District74100 TarantoItaly Institute of Behavioural Science G.De Lisio56100 PisaItaly

Recent research on autoimmune disorders suggests additional links between systemic and central nervous system(CNS)pathophysiology,among which the identification of antibody-induced limbic encephalitis provided the strongest evidence for the potential involvement of autoimmunity in the pathogenesis of severe mood and psychotic *** these illnesses,psychiatric symptoms predominate in the initial phase of the disorder in up to 70%of the cases,and they often lead patients to early psychiatric *** this reason,it is very important to increase the limited knowledge among psychiatrists about these autoimmune neuropsychiatric diseases,which can mimic psychiatric syndromes,in particular,those typically presented in severe mood disorders and *** the other hand,similarities in clinical presentation suggest that neuroinflammation and systemic immune dysregulation may play a role in the pathophysiology of severe mood and psychotic disorders.A complex interaction between periphery and immune cells of the CNS may result in cellular damage through mechanisms involving excitotoxicity,oxidative stress,and mitochondrial *** pathways are possibly shared between comorbid medical disorders and severe mood and psychotic disorders and may reflect common underlying vulnerability.

关键词： Autoimmune encephalitis mood disorders psychosis

The role of anti-glutamic acid decarboxylase autoantibodies in mood disorders

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Neuroimmunology and Neuroinflammation 2015年第1期2卷 237-243页

作者： Marco Liguori Mirko Manchia Leonardo Tondo Laboratory of Microbiology and Immunology G.Brotzu Hospital09121 CagliariItaly Department of Pharmacology Dalhousie UniversityHalifaxNS B3H 4R2Canada Department of Public Health Clinical and Molecular MedicineUniversity of Cagliari09124 CagliariItaly mood Disorder Lucio Bini Center 09128 CagliariItaly mood Disorder Lucio Bini Center 00193 RomeItaly McLean Hospital Harvard Medical SchoolBoston 02115MAUSA

Gamma-aminobutyric acid(GABA)possibly plays a causative role in mood *** hypothesis originated with studies on the beneficial effect of valproate in mania and as a mood *** valproate is known for its action in increasing the level of GABA,it was indirectly suggested that decreasing levels of GABA were responsible for mood *** identify factors causing the decreased levels of GABA,studies have concentrated on the activity of the enzyme L-glutamic acid decarboxylase(GAD),which catalyzes the transformation of glutamate to GABA,as a decreasing function of this enzyme induces lower levels of the ***,a very limited amount of research investigated the possible role of glutamic acid decarboxylase antibodies(GADA)in determining a decreased enzymatic function of *** these findings are confirmed,it will be possible to improve diagnosis and treatment of mood *** addition,if the presence of GADA is associated with a genetic trait,this would allow and facilitate early diagnoses.

关键词： Autoantibodies bipolar disorder gamma‑aminobutyric acid glutamate L‑glutamic‑acid decarboxylase antibodies mood disorders

Comprehensive Bibliometric Analysis of the Kynurenine Pathway in mood disorders:Focus on Gut Microbiota Research

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Comprehensive Bibliometric Analysis of the Kynurenine Pathwa...

The Protocadherin 17 Gene Affects Cognition, Personality, Amygdala Structure and Function, Synapse Development and Risk of Major mood disorders

2022第27届广东省药师周大会

作者： Xiuqing Zhu Jinqing Hu Shuhua Deng Yaqian Tan Chang Qiu Ming Zhang Xiaojia Ni Haoyang Lu Zhanzhang Wang Lu Li Yayan Luo Shanqing Huang Tao Xiao Shujing Liu Xiaolin Li Dewei Shang Yuguan Wen Department of Pharmacy The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital) Guangdong Engineering Technology Research Center for Translational Medicine of Mental disorders GuangzhouChina 3Institute of NeuropsychiatryThe Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital)

Background:Emerging evidence implicates the dysregulated kynurenine pathway(KP),an immune-inflammatory pathway,in the pathophysiology of mood disorders(MD),including depression and bipolar disorder characterized by a low-grade chronic pro-inflammatory *** metabolites of the KP,an important part of the microbiota-gut-brain axis,serve as immune system modulators linking the gut microbiota(GM) with the host central nervous ***:This bibliometric analysis aimed to provide a first glimpse into the KP in MD,with a focus on GMresearch in this field,toguide future researchand promote the development of this ***:Publications relating to the KP in MD between the years 2000 and 2020 were retrieved from the Scopus and Web of Science Core Collection(WoSCC),and analyzed in CiteSpace(5.7 R5 W),biblioshiny(using R-Studio),and VOSviewer(1.6.16).Results:In total,1,064 and 948 documents were extracted from the Scopus and WoSCC databases,*** publications have shown rapid growth since 2006,partly owing to the largest research hotspot appearing since then,"quinolinic acid." All the top five most relevant journals were in the neuropsychiatry field,such as Brain Behavior and *** USA and Innsbruck Medical University were the most influential country and institute,*** co-citation analysis showed a strong tendency toward co-citation of research in the psychiatry *** co-citation analysis revealed that the top four most important research focuses were "kynurenine pathway,""psychoneuroimmunology," "indoleamine2,3-dioxygenase," and "proinflammatory cytokines,"and the most recent focuswas "gut-brain axis," thus indicating the role of the KP in bridgingthe GM and the host immune system,and togetherreflecting the field’s research *** analysis between the thematic map of keywords and the keyword burst analysis revealed that the topics "Alzheimer’s disease," "prefrontal cortex," and "acid," were research frontiers

关键词： kynurenine pathway mood disorders depression bipolar disorder bibliometric analysis gut microbiota microbiota-gut-brain axis immune system

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The Protocadherin 17 Gene Affects Cognition, Personality, Am...

Correlation of preoperative inflammatory factors and emotional disorders with postoperative delirium in patients with craniocerebral trauma

中国神经科学学会第十二届全国学术会议

作者： Hong Chang Naosuke Hoshina Yina Ma Hengyi Cao Andreas Meyer-Lindenberg Heike Tost Xiao Xiao Tadashi Yamamoto Ming Li Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province Kunming Institute of Zoology Cell Signal Unit Okinawa Institute of Science and Technology Graduate University State Key Laboratory of Cognitive Neuroscience and Learning IDG/McGovern Institute for Brain Research Beijing Normal University Department of Psychiatry and Psychotherapy Central Institute of Mental Health Medical Faculty Mannheim University of Heidelberg

Objective: Major mood disorders, which primarily include bipolar disorder and major depressive disorder, are the leading cause of disability worldwide and pose a major challenge in identifying robust risk genes. Methods: An integrative analysis involving genetics, m RNA expression, cognitive performance, neuroimaging and neurobiology was performed. Results: We present data from independent large-scale clinical datasets（including 29,557 cases and 32,056 controls） revealing brain expressed protocadherin 17（PCDH17） as a susceptibility gene for major mood disorders. Single nucleotide polymorphisms（SNPs） spanning the PCDH17 region are significantly associated with major mood disorders;subjects carrying the risk allele showed impaired cognitive abilities, increased vulnerable personality features, decreased amygdala volume and altered amygdala function as compared with non-carriers. The risk allele predicted higher transcriptional levels of PCDH17 m RNA in postmortem brain samples, which is consistent with increased gene expression in patients with bipolar disorder compared with healthy subjects. Further, overexpression of PCDH17 in primary cortical neurons revealed significantly decreased spine density and abnormal dendritic morphology compared with control groups, which again is consistent with the clinical observations of reduced numbers of dendritic spines in the brains of patients with major mood disorders. Conclusions: Given that synaptic spines are dynamic structures which regulate neuronal plasticity and play crucial roles in myriad brain functions, this study reveals a potential underlying biological mechanism of a novel risk gene for major mood disorders involved in synaptic function and related intermediate phenotypes.

关键词： PCDH17 mood disorders amygdala expression dendritic spines

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World Journal of Psychiatry 2024年第7期14卷 1043-1052页

作者： Peng Cao Zhe-Yong Jia Tao Zheng Tao Mei Department of Neurosurgery Changde HospitalXiangya School of MedicineCentral South University(The First People’s Hospital of Changde City)Changde 415003Hunan ProvinceChina

BACKGROUND Traumatic brain injury(TBI)imposes a substantial societal and familial burden due to its high disability and fatality rates,rendering it a serious public health *** patients with TBI have poor treatment outcomes and are prone to postoperative delirium(POD),which affects their quality of *** has been linked to increased POD incidence in some studies,while others have found no *** To investigate the correlation of POD risk factors,preoperative inflammatory factors,and mood disorders in patients with *** We retrospectively collected data on the treatment of 80 patients with TBI from November 2021 to September *** were grouped as POD and non-POD,according to their POD status,and the general data of the two groups were *** factor levels were detected preoperatively,and the Hamilton Depression Scale(HAMD)and Hamilton Anxiety Scale(HAMA)were used to investigate the risk factors associated with POD in these *** regression was used to identify the independent risk *** Twenty-one patients(26.25%)developed POD,including 7,10,and 4 cases of the excitatory,inhibitory,and mixed types,*** were 59 cases(73.75%)in the non-POD *** with the non-POD group,the POD group had a significantly higher proportion of patients with low Glasgow Coma Scale(GCS)scores before admission,unilateral mydriasis,preoperative hemorrhagic shock,intraventricular hemorrhage(IVH),and postoperative hyperglycemic hyperosmolar disease(P<0.05).In the POD group,interleukin-6(IL-6),human tumor necrosis factor-α(TNF-α),myeloperoxidase levels,HAMA,and HAMD scores were higher than those in the non-POD group(all P<0.05).Logistic multivariate analysis showed that GCS score at admission,IVH,IL-6,TNF-α,HAMA,and HAMD were independent risk factors for POD in patients with TBI(P<0.05).CONCLUSION Low GCS score at admission,IVH,elevated IL-6 and TNF-α,other inflammatory indicators,anxiety,and depress

关键词： Inflammatory factors mood disorders Traumatic brain injury Postoperative delirium Relevance Risk factor

Effectivenss of electroacupuncture for skeletal muscle pain in Parkinson's disease:a Clinical randomized controlled trial

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Journal of Traditional Chinese Medicine 2024年第2期44卷 388-395页

作者： WANG Shaosong SUN Jingqing FENG Qingyin LI Bin WANG Xin YUAN Fan CUI Yingxue Department of acupuncture Beijing Hospital of Traditional Chinese MedicineBeijing 100010China

OBJECTIVE:To explore the effect of electroacupuncture on skeletal muscle pain in Parkinson's disease(PD).METHODS:A single-center randomized controlled trial was conducted with sixty patients with Parkinson's disease with skeletal muscle pain were randomly divided into electroacupuncture group and sham acupuncture control group with 30 patients *** electric acupuncture group was treated with electric acupuncture,while the control group was treated with Park needle *** groups were treated 5 times a week for a total of 4 weeks,and both groups completed 20 ***'s Parkinson's Pain Scale(KPPS)and visual analog scale(VAS)were used before and after treatment to evaluate the pain degree of *** shear wave elastography(SWE)and modified Ashworth score(MAS)were used to evaluate the changes of muscle ***'s comprehensive Score Scale(MDS-UPDRS,including UPDRS Ⅱ and UPDRS Ⅲ)was used to evaluate exercise *** Depression Scale(HAMD)score was used to evaluate the emotional changes of *** correlation analysis was used to explore the correlation between pain degree and muscle tone,exercise ability and ***:During the study,one case fell off in the control group,and 30 cases were eventually included in the analysis and treatment group and 29 cases in the control *** treatment,Young's modulus of biceps and quadriceps and shear wave velocity of biceps were decreased in electroacupuncture group compared with before treatment,while KPPS score,VAS score,UPDRS Ⅱ,UPDRS Ⅲ and modified Ashworth score were decreased,with statistical significance(P0.05).After treatment,KPPS score,VAS score,UPDRS Ⅱ and UPDRS Ⅲ,MAS,HAMD score,Young's modulus of biceps and shear wave velocity in electroacupuncture group were significantly lower than those in control group(P<0.05).Spearman correlation analysis showed that KPPS score was positively correl

关键词： Parkinson disease muscle skeletal pain electroacupuncture muscle tention mood disorders randomized controlled trial

Effectiveness of Xiaoyao capsule(逍遥丸)on sleep disorders and mood disturbance in patients in recovery from coronavirus disease 2019:a randomized controlled trial

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Journal of Traditional Chinese Medicine 2023年第2期43卷 343-351页

作者： YANG Cunqing LIAN Fengmei YANG Guiping HUANG Yufeng ZHANG Shuangbin WANG Jianghua ZHOU Jing GUO Dongqing SHEN Chuanyun YE Tiansong FU Aojie LI Xiaoli CHEN Le ZHANG Huifeng TU Qiyin WANG Ying YANG Wenzhe TONG Xiaolin BA Yuanming Department of Endocrinology Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China Department of Gastroenterology Xiaogan Hospital of Traditional Chinese MedicineXiaogan 432100China Party Committee Office of Xiaogan Hospital of Traditional Chinese Medicine Xiaogan 432100China Department of Nephrology Xiaogan Hospital of Traditional Chinese MedicineXiaogan 432100China Department of internal Medicine Xiaogan Hospital of Traditional Chinese MedicineXiaogan 432100China Liver Disease Branch Xiaogan Hospital of Traditional Chinese MedicineXiaogan 432100China Department of massage Xiaogan Hospital of Traditional Chinese MedicineXiaogan 432100China Department of Medicine Xiaogan Hospital of Traditional Chinese MedicineXiaogan 432100China Department of internal Medicine Dawu County Hospital of Traditional Chinese MedicineXiaogan 432800China Department of Pulmonary Diseases Xiaogan Hospital of Traditional Chinese MedicineXiaogan 432100China Pharmaceutical Preparation Section Xiaogan Hospital of Traditional Chinese MedicineXiaogan 432100China Acupuncture and Moxibustion Deparment Xiaogan Hospital of Traditional Chinese MedicineXiaogan 432100China Institute of Metabolic Diseases Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China Department of nephropathy Hubei Provincial Hospital of Traditional Chinese MedicineWuhan 430061China

OBJECTIVE:To study the efficacy of Xiaoyao capsule(逍遥丸)in improving the clinical symptoms of sleep and mood disorders during recovery from coronavirus disease 2019(COVID-19).METHODS:The study cohort comprised 200 patients with sleep and mood disorders during recovery from *** were randomized into the control group and the experimental group in a 1:1 ratio by blocked *** patients received either Xiaoyao capsule(experimental group)or a placebo Xiaoyao capsule(control group)for 2 *** improvements in the Traditional Chinese Medicine(TCM)syndrome scales,total effective rates,and disappearance rates of irritability,anxiety,and poor sleep were compared between the two ***:The TCM syndrome pattern scales,total effective rates,and disappearance rates of irritability,anxiety,and poor sleep did not significantly differ between the experimental group versus the control group in the full analysis set and the per protocol set after 1 and 2 weeks of treatment(P>0.05).CONCLUSIONS:Xiaoyao capsule do not significantly improve the clinical symptoms of sleep and mood disorders in patients in recovery from COVID-19.

关键词： COVID-19 sleep wake disorders mood disorders Xiaoyao capsule