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Acute and subacute oral toxicity study on the flavonoid rich fraction of monodora tenuifolia seed in albino rats

Asian Pacific Journal of Tropical Biomedicine 2014年第3期4卷 194-202页

作者： Raphael Chukwuma Ekeanyanwu Obioma Uzoma Njoku Department of Biochemistry Faculty of SciencesImo State University OwerriImo StateNigeria Department of Biochemistry Faculty of Biological SciencesUniversity of Nigeria NsukkaEnugu StateNigeria

Objective:To investigate the effects of the flavonoid rich fraction of monodora tenuifolia seed on the haematology,histopathology and liver profile of Wistar albino ***:Toxicity study was investigated on the flavonoid rich fraction of monodora tenuifolia in rats administered different concentrations orally for 28 d using standard laboratory ***:The LD_(50)of the flavonoid rich fraction was found to be above 5000 mg/kg body weight in mice observed for 48 *** the Day 14,biochemical markers of liver injury such as serum alanine aminotransferase,and aspartate aminotransferase decreased significantly(P0.05).There was non-significant(P>0.05)effect observed across the groups in the levels of serum total protein,albumin,globulin,urea and *** result of histological examination showed various degrees of peribiliary hepatitis after the Day 14 which fizzled out after the Day ***:The result therefore suggests that the seed extract is potentially safe.

关键词： monodora tenuifolia Toxicity Haematological parameters Biochemical parameters Histology

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Potentials of Two Nigerian Spices—<i>Piper nigrum</i>and <i>monodora myristica</i>as Sources for Cheap Natural Antioxidants

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American Journal of Plant Sciences 2013年第5期4卷 1105-1115页

作者： Edak A. Uyoh Peter N. Chukwurah Roseline C. Akarika Victoria A. Antia Department of Genetics and Biotechnology University of Calabar Calabar Nigeria.

Two commonly consumed spices in Nigeria—Piper nigrum (leaf and seed) and monodora myristica (seed) were evaluated for natural antioxidant potentials in complementary in vitro assay systems. Extracts of the tested plant parts contained low amounts of antioxidant compounds: 4.00 - 6.65 μg GAE/mg and 2.50 - 10.38 μg RE/mg for phenols and flavonoids respectively. The extracts scavenged DPPH and hydroxyl radicals in the range of 4.32% - 37.37% (inferior to ascorbic acid and gallic acid used as standards) and 6.43% - 17.10% respectively. In the reducing power and phosphomolybdenum assays, the extracts showed ability to reduce Fe (III) and Mo (VI) ions to their lower valence states of Fe (II) and Mo (V) respectively, although these activities were inferior to those of the standards used. Comparatively, monodora myristica seed extract was superior to Piper nigrum leaf and seed extracts in antioxidant potential, but all the extracts generally showed dose-dependent antioxidant activities. Evidently, the studied spice plants are not without some natural antioxidant capacity and would contribute appreciably in combating free radical damages when consumed.

关键词： Antioxidant Piper nigrum monodora myristica Spices Free Radicals

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