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Hepatitis C virus reactivation in cancer patients in the era of targeted therapies

World Journal of Gastroenterology 2014年第22期20卷 6716-6724页

作者： Ozan Yazici Mehmet Ali Nahit ?endur Sercan Aksoy Department of Medical Oncology Ankara Numune Education and Research HospitalAnkara 06100Turkey Department of Medical Oncology Hacettepe University Cancer InstituteAnkara 06100Turkey

The purpose of this review is to summarize the evidence of hepatitis C reactivation in cancer patients in the era of targeted *** therapies are novel therapeutics frequently used in cancer *** treatment with targeted therapies,viral replication is one of the major problems that can *** PubMed database,ASCO,and ASCO Gastrointestinal Cancer Symposium abstracts were searched up until September 15,2013 using the following search keywords:"targeted therapies,rituximab,alemtuzumab,brentuximab,hepatitis,hepatitis C reactivation,tyrosine kinase inhibitors,imatinib,mammalian target of rapamycin(mTOR)inhibitors,everolimus,anti-HER therapies,trastuzumab,pertuzumab,lapatinib,antiepidermal growth factor receptor therapies,cetuximab,panitumumab,and ipilimumab".Papers considered relevant for the aim of this review were selected by the *** data about rituximab-induced hepatic flare in hepatitis C virus(HCV)positive patients is ***,there is the possibility of life-threatening hepatic flare that can develop after HCV ribonucleic acid(HCV-RNA)viral load *** followup of liver function tests should be *** in high-risk patients,such as those with baseline chronic active hepatitis and cirrhosis,and where there are plans to administer rituximab concomitantly with corticosteroids,it is advised to have close follow-up of HCV viral *** data is insufficient to make accurate statements about the association of alemtuzumab therapy and HCV ***,alemtuzumab may cause deep *** to this,it is better to follow up with liver function tests and HCV RNA levels during alemtuzumab *** has effects on antibody dependent cellular toxicity and may decrease humoral ***,we believe that during brentuximab treatment of HCV infected patients,clinicians may encounter hepatitis C *** have been no reported cases of hepatitis C reactivation with imatini

关键词： Hepatitis C Hepatitis C reactivation mono-clonal a

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