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Phytochemical screening and antibacterial activities of momordica charantia and Vernonia amygdalina extracts on some selected enteric isolates

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TMR Modern Herbal Medicine 2024年第1期7卷 11-18页

作者： Seyi-Samson Enitan Zaynab-Aderonke Ojubanire Temiloluwa-Femi Oyedele Nwachi-Idume Ogbonna Adekunle-Totoola Adeyemi Jamiu-Monsur Olalekan Ayomide-Oluwatobiloba Okuneye Department of Medical Laboratory Science Babcock University Ilishan-RemoOgun state 121103Nigeria Department of Medical Microbiology Babcock University Teaching HospitalIlishan-RemoOgun State 121103Nigeria Department of Education Medical Laboratory Science Council of NigeriaFCT-Abuja 900110Nigeria Clinical Laboratory Department Central Medical Diagnostic CentreIbadan 200113Nigeria

Background:This research focuses on herbal medicine,an ancient healthcare practice,exploring the antibacterial attributes of fresh and dried leaf extracts from momordica charantia(commonly known as Bitter melon)and Vernonia amygdalina(Bitter leaf).The study specifically investigates their effects on different bacterial strains associated with gastroenteritis.Methods:Four enteric bacterial isolates-Klebsiella pneumoniae,Salmonella typhi,Escherichia coli,and Proteus mirabilis-were obtained from the Medical Laboratory Unit at Babcock University Teaching Hospital in Ilishan-Remo,Ogun State.Phytochemical screening and antibacterial testing were conducted using standard biochemical techniques and the Punch-hole agar diffusion method,respectively.Results:Qualitative phytochemical screening of the plant extracts revealed the presence of flavonoids,glycosides,and saponin in both plants,excluding terpenoids.Alkaloids were identified only in Vernonia amygdalina.Despite these phytochemicals,neither plant displayed inhibitory effects on the tested bacterial isolates(Escherichia coli,Proteus mirabilis,Klebsiella pneumoniae,and Salmonella typhi)when tested individually or in combination.Intriguingly,combining the fresh and dried leaf extracts of momordica charantia and Vernonia amygdalina with a standard drug resulted in smaller mean zone diameters of inhibition(Escherichia coli range:14 mm–16 mm,Proteus mirabilis range:31 mm–35 mm,Klebsiella pneumoniae range:13 mm–22 mm,and Salmonella typhi range:35 mm–38 mm)compared to the drug tested alone(16 mm–45 mm).Conclusion:Despite previous indications of antibacterial properties in various extracts of V.amygdalina and M.charantia leaves,our study presents contradictory results,prompting the need for further investigation despite the presence of significant phytochemicals.

关键词： phytochemical screening herbal medicine momordica charantia Vernonia amygdalina enteric isolates

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Chemical Composition and Use of momordica charantia L. and Hyptis spicigera Lam. Extracts as Mosquito Larvicides and Insect Growth Regulators against Malarial Vector, Anopheles gambiae Giles

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Advances in Entomology 2023年第2期11卷 47-62页

作者： David Ngadvou Simon Pierre Yinyang Danga Bouladji Yonki Elias Nchiwan Nukenine Department of Biological Sciences Faculty of Science University of Ngaoundere Ngaoundere Cameroon Department of Physiological Sciences and Biochemistry Faculty of Medicine and Biomedical Sciences of Garoua University of Garoua Garoua Cameroon

Background: Mosquitoes are responsible of numerous vector-borne diseases and among these diseases is malaria which takes away lives of thousands of people, especially children of under five, particularly in Africa. To reduce the mortality and economic burdens of this deadly disease, synthetic insecticide has been of use to control its main vector, Anopheles gambiae. Due to adverse effects caused by these conventional products on non-target organisms and the environment, plants have been of first choice as they proved their effectiveness against mosquitoes and are said to be eco-friendly and relatively safer. Therefore, the aim of this study was to screen the phytochemicals and determine the larvicidal and adult emergence exhibitory activities of momordica charantia and Hyptis spicigera leaves extracts against Anopheles gambiae larvae. Methods: The WHO standard protocol for larvicidal activity and IGRs was followed up and concentrations from 500 - 2000 ppm for larvicidal and 500 - 1500 ppm for IGRs were set up. Results: There was the presence of alkaloids, flavonoids, tannins, phenols, steroids, terpenoids and oils in momordica charantia against alkaloids, taponins, tannins, phenols, steroids, terpenoids and oils in Hyptis spicigera. Methanol crude extract registered the lowest LC50 value of 270.6 ppm followed by ethyl acetate and hexane fractions recorded the LC50 of 742.1 and 756 ppm, respectively for larvicidal activity of momordica charantia against LC50 of 760 and 867.5 ppm for hexane fraction and methanol crude extract, respectively for Hyptis spicigera. Methanol crude extract and hexane fraction of both plants as well as the ethyl acetate fraction of M. charantia registered greater emergence inhibition with IE50 values of 590.2, 842.3 and 982 ppm for methanol crude extract, hexane and ethyl acetate fractions of M. charantia, respectively against 901.7 and 873.2 for methanol crude extract and hexane fraction of H. spicigera, respectively. Conclusion: The toxicity a

关键词： momordica charantia Hyptis spicigera Anopheles gambiae Malaria Extracts IGRs

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Cucurbitane-Type Triterpene Glycosides from momordica charantia and Their α-Glucosidase Inhibitory Activities

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Natural Products and Bioprospecting 2020年第3期10卷 153-161页

作者： Ya Gao Jian-Chao Chen Xing-Rong Peng Zhong-Rong Li Hai-Guo Su Ming-Hua Qiu State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201People’s Republic of China University of the Chinese Academy of Sciences Beijing 100049People’s Republic of China Yunnan Key Laboratory of Natural Medicinal Chemistry Chinese Academy of SciencesKunming 650201People’s Republic of China

Ten cucurbitane-type triterpene glycosides,including five new compounds named charantosides H(1),J(2),K(3),momor-characoside A(4),goyaglycoside-l(5),and five known compounds(6-10),were isolated from the EtOAc extract of Momor-dica charantia fruits.The chemical structures of these compounds were identified by 1D and 2D NMR and HRESIMS spectroscopic analyses.Configurations of new compounds were determined by ROESY correlations and comparison of their 13C NMR data with literature reported values.All compounds were evaluated for their inhibition againstα-glucosidase,in which compounds 2,5,7,8,9 showed moderate inhibitory activities with IC50 values ranging from 28.40 to 63.26μM comparing with the positive control(acarbose,IC5087.65±6.51μM).

关键词： momordica charantia Cucurbitane-type triterpene glycosides α-Glucosidase inhibitory activity

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Impact of Extraction on Biochemical Properties and Antioxidant Potential of momordica charantia L. Seeds’ Oil

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Food and Nutrition Sciences 2022年第2期13卷 147-164页

作者： Balde Samba Ayessou Nicolas Cyrille Khadim Niane Bou Ndiaye Mady Cisse Codou Mar Diop Centre d’Etude sur la Sécurité Alimentaire et les Molécules fonctionnelles (CESAM) Université Cheikh Anta DIOP de Dakar Fann Sénégal

In this study, the influence of provenance and extraction methods on the physicochemical properties and the antioxidant potential of M. charantia seeds oil were evaluated. The oil is obtained on the one hand by cold extraction with hexane and on the other hand by hot extraction with soxhlet. The results obtained show that the extraction yield is significantly impacted by the extraction methods and the origin of the seeds. In addition, the soxhlet extraction gives a higher oil yield (32.07 ± 0.01). Cold extraction has made it possible to obtain oils with less attenuated physicochemical characteristics. Indeed, the acid numbers are high in the oils extracted by soxhlet (5.92 ± 0.25;4.25 ± 0.62 and 13.86 ± 0.83) than in those cold extracted with very low peroxide for all the oils obtained. On the other hand, the iodine and refractive indices are high in oils obtained cold (91.58 ± 0.85;100.74 ± 0.03 and 102.08 ± 0.28) (1.53 ± 0.01;1.52 ± 0.01 and 1.52 ± 0.01) with low saponification indices. The polyphenol concentrations and the anti-free radical activity are higher with the oils obtained cold (0.086 ± 0.001;0.08 ± 0.000 and 0.09 ± 0.01 mgEAG/g of oil) and (DPPH) (55.75% ± 1.16%;55.03% ± 0.72% and 56.35% ± 0.45%). The color parameters (L*, a* and b*) of the different oils extracted also vary depending on the extraction method used. Principal Component Analysis (PCA) and correlation analysis were performed on the physicochemical properties and the antioxidant potential of the extracted oils. Therefore, the results suggest cold extraction to obtain a good quality and oxidation resistant oil.

关键词： momordica charantia Oil Antioxidant Potential Extraction

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A new cucurbitane triterpenoid from momordica charantia

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Chinese Chemical Letters 2007年第7期18卷 843-845页

作者： Qing Yan Li Hong Liang Hu Biao Chen Bin Wang Yu Ying Zhao Department of Natural Medicines School of Pharmaceutical Sciences Peking University Health Science Center Beijing 100083 China State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical Science Peking University Beijing 100083 China

One new cucurbitane-type triterpenoid saponin, 5β,19-epoxycucurbita-6,23-diene-3β,19,25-triol-3-O-β-D-allopyranoside （1）,named momordicoside P was isolated from the fresh fruits ofmomordica charantia. The structu... 详细信息

关键词： momordica charantia Cucurbitane triterpenoid Saponin Momordicoside P

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Antifeedant Activity and Active Ingredients Against Plutella xylostella from momordica charantia Leaves

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Agricultural Sciences in China 2008年第12期7卷 1466-1473页

作者： LING Bing WANG Guo-cai YA Ji ZHANG Mao-xin LIANG Guang-wen Laboratory of Insect Ecology South China Agricultural University Guangzhou 510642 P.R.China Institute of Traditional Chinese Medicine ＆ Natural Products Jinan University Guangzhou 510632 P.R.China

With the bioguided fractionation of the ethanol extracts from the leaves of momordica charantia, we obtained two most active compounds against the feeding of the diamondback moth, Plutella xylostella larvae. The antifeedant activity of momordicine Ⅰ and momordicine Ⅱ against the second and the third instar larvae of Plutella xylostella were tested using leaf discs of cabbage in the laboratory. The results showed that momordicin Ⅰ and momordicin Ⅱ had significant antifeedant activity on the larvae of P. xylostella, and momordicin Ⅱ was more active than momordicin Ⅰ. The concentrations for 50% antifeedant effects （AFC50） of momordicin Ⅱ against the second and the third instar larvae of P. xylostella were 76.69 and 116.24μg mL^-1, whereas that of momordicin I was 144.08 and 168.42μg mL^-1, respectively. In addition, momordicin Ⅰ and momordicin Ⅱ had significant inhibitive effect on the rate of weight gain and survival of P. xylostella larvae.

关键词： momordica charantia Plutella xylostella antifeedant activities momordicin Ⅰ momordicin Ⅱ

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A New Cucurbitane Triterpene in Acid-treated Ethanol Extract from momordica charantia

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Chinese Herbal Medicines 2013年第3期5卷 234-236页

作者： CAO Jia-qing ZHANG Bo-yu ZHAO Yu-qing School of Traditional Chinese Materia Madica Shenyang Pharmaceutical University Department of Pharmacy Liaoning University of Traditional Chinese Medicine Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education Shenyang Pharmaceutical University

Objective To study the chemical constituents in the acid-hydrolyzed ethanol extract from momordica charantia.Methods The ethanol extract from M.charantia was hydrolyzed by 36%HCl and the hydrolysate was isolated by silica gel column chromatography and preparative HPLC.The structures of the isolated compounds were identified by spectral analyses,physical constants,and chemical evidences.Results Two cucurbitane triterpenoids were isolated and identified as 5β,19-epoxy-cucurbita-6,22E,24-trien-3β-ol(1)and cucurbita-6,22(E),24-trien-3β-ol-19,5β-olide(2).Conclusion Compound 1 is a new compound.

关键词： cucurbitane 5β,19-epoxy-cucurbita-6,22(E),24-trien-3β-ol hydrolysate momordica charantia triterpene

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环己亚胺对苦瓜(momordica charantia)胚珠和胚发育的影响

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植物生理学报 1984年第2期 27-28+64页

作者：黄庆榴中国科学院上海植物生理研究所

有关高等植物胚胎发育生理的研究迄今依然较少,特别是葫芦科植物,虽然它们具有很大的经济价值,但是对其种胚发育的研究只限于少数的一些种,至于种胚发育生理及其调控方面则更未见报道。本文探讨了苦瓜种胚发育过程和环己亚胺对它们的影响。

关键词：环己亚胺 momordica charantia 胚珠大孢子囊心皮胚发育苦瓜

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Exploring the mechanism of action bitter melon in the treatment ofbreast cancer by network pharmacology

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World Journal of Experimental Medicine 2023年第5期13卷 142-155页

作者： Kavan Panchal Bhavya Nihalani Utsavi Oza Aarti Panchal Bhumi Shah Pharmaceutical Chemistry L.J.Institute of PharmacyL J UniversityGujaratAhmedabad 382210India

BACKGROUND Bitter melon has been used to stop the growth of breast cancer(BRCA)cells.However,the underlying mechanism is still unclear.AIM To predict the therapeutic effect of bitter melon against BRCA using network pharmacology and to explore the underlying pharmacological mechanisms.METHODS The active ingredients of bitter melon and the related protein targets were taken from the Indian Medicinal Plants,Phytochemistry and Therapeutics and SuperPred databases,respectively.The GeneCards database has been searched for BRCA-related targets.Through an intersection of the drug’s targets and the disease’s objectives,prospective bitter melon anti-BRCA targets were discovered.Gene ontology and kyoto encyclopedia of genes and genomes enrichment analyses were carried out to comprehend the biological roles of the target proteins.The binding relationship between bitter melon’s active ingredients and the suggested target proteins was verified using molecular docking techniques.RESULTS Three key substances,momordicoside K,kaempferol,and quercetin,were identified as being important in mediating the putative anti-BRCA effects of bitter melon through the active ingredient-anti-BRCA target network study.Heat shock protein 90 AA,proto-oncogene tyrosine-protein kinase,and signal transducer and activator of transcription 3 were found to be the top three proteins in the proteinprotein interaction network study.The several pathways implicated in the anti-BRCA strategy for an active component include phosphatidylinositol 3-kinase/protein kinase B signaling,transcriptional dysregulation,axon guidance,calcium signaling,focal adhesion,janus kinase-signal transducer and activator of transcription signaling,cyclic adenosine monophosphate signaling,mammalian CONCLUSION Overall,the integration of network pharmacology,molecular docking,and functional enrichment analyses shed light on potential mechanisms underlying bitter melon’s ability to fight BRCA,implicating active ingredients and protein targets,as well as highlighting the major signalin

关键词： Bitter melon momordica charantia Network pharmacology Molecular docking Breast cancer Indian Medicinal Plants,Phytochemistry and Therapeutics

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Bitter melon： a panacea for inflammation and cancer

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Chinese Journal of Natural Medicines 2016年第2期14卷 81-100页

作者： Prasad R. Dandawate Dharmalingam Subramaniam Subhash B. Padhye Shrikant Anant Department of Molecular and Integrative Physiology The University of Kansas Medical Center Kansas City KS 66160 USA Department of Surgery The University of Kansas Medical Center Kansas City KS 66160 USA The University of Kansas Cancer Center Kansas City KS 66160 USA Interdisciplinary Science & Technology Research Academy Abeda lnamdar Senior College Azam Campus Pune 411001 lndia

Nature is a rich source of medicinal plants and their products that are useful for treatment of various diseases and disorders. momordica charantia, commonly known as bitter melon or bitter gourd, is one of such plants known for its biological activities used in traditional system of medicines. This plant is cultivated in all over the world, including tropical areas of Asia, Amazon, east Africa, and the Caribbean and used as a vegetable as well as folk medicine. All parts of the plant, including the fruit, are commonly consumed and cooked with different vegetables, stir-fried, stuffed or used in small quantities in soups or beans to give a slightly bitter flavor and taste. The plant is reported to possess anti-oxidant, anti-inflammatory, anti-cancer, anti-diabetic, anti-bacterial, anti-obesity, and immunomodulatory activities. The plant extract inhibits cancer cell growth by inducing apoptosis, cell cycle arrest, autophagy and inhibiting cancer stem cells. The plant is rich in bioactive chemical constituents like cucurbitane type triterpenoids, triterpene glycosides, phenolic acids, flavonoids, essential oils, saponins, fatty acids, and proteins. Some of the isolated compounds(Kuguacin J, Karaviloside XI, Kuguaglycoside C, Momordicoside Q-U, Charantin, α-eleostearic acid) and proteins(α-Momorcharin, RNase MC2, MAP30) possess potent biological activity. In the present review, we are summarizing the anti-oxidant, anti-inflammatory, and anti-cancer activities of momordica charantia along with a short account of important chemical constituents, providing a basis for establishing detail biological activities of the plant and developing novel drug molecules based on the active chemical constituents.

关键词： momordica charantia Bitter melon Anti-oxidant activity Anti-inflammatory activity Anti-cancer activity Natural products

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