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molluscicidal effectiveness of Luo-Wei,a novel plant-derived molluscicide,against Oncomelania hupensis,Biomphalaria alexandrina and Bulinus truncatus

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Infectious Diseases of Poverty 2019年第2期8卷 70-79页

作者： Tie-Wu Jia Wei Wang Le-Ping Sun Shan Lv Kun Yang Neng-Min Zhang Xi-Bao Huang Jian-Bing Liu Han-Cheng Liu Rui-Hua Liu Fathia A.Gawish Mohamed R.Habib Mohamed A.El-Emam Charles H.King Xiao-Nong Zhou National Institute of Parasitic Diseases Chinese Center for Disease Control and PreventionShanghai 200025China Chinese Center for Tropical Diseases Research Shanghai 200025China WHO Collaborating Centre for Tropical Diseases Shanghai 200025China National Center for International Research on Tropical Diseases Ministry of Science and TechnologyShanghai 200025China Key Laboratory of Parasite and Vector Biology Ministry of HealthShanghai 200025China Communicable Diseases Cluster World Health Organization Regional Office for Africa(WHO/AFRO)PO Box 06BrazzavilleCongo Key Laboratory of National Health Commission on Parasitic Disease Control and Prevention Jiangsu Provincial Key Laboratory on Parasites and Vector Control TechnologyJiangsu Institute of Parasitic DiseasesWuxi 214064China Hubei Jinhaichao Science&Technology Co. LtdWuhan 430206China Hubei Provincial Center for Disease Control and Prevention Wuhan 430079China School of Chemistry and Chemical Engineering Wuhan Textile UniversityWuhan 430200China Department of Medical Malacology Theodor Bilharz Research Institute(TBRI)ImbabaGiza 12411Egypt Center for Global Health and Diseases Case Western Reserve UniversityClevelandOHUSA Schistosomiasis Consortium for Operational Research and Evaluation University of GeorgiaAthensGAUSA

Background:Control of snail intermediate hosts has been proved to be a fast and efficient approach for interrupting the transmission of schistosomiasis.Some plant extracts have shown obvious molluscicidal activity,and a new compound Luo-Wei,also named tea-seed distilled saponin(TDS),was developed based on the saponins extracted from Camellia oleifera seeds.We aimed to test the molluscicidal activity of 4%TDS against the intermediate host snails in China and Egypt,and evaluate its environmental safety to non-target organisms.Methods:In the laboratory,Oncomelania hupensis,Biomphalaria alexandrina and Bulinus truncatus were exposed to 4%TDS,and the median lethal concentration(LC5o)was estimated at 24,48 and 72 h.In the field,snail mortalities were assessed 1,2,3 and 7 d post-immersion with 2.5 g/m34%TDS and 1,3,7 and 15 d post-spraying with 5 g/m24%TDS.in addition,the acute toxicity of 4%TDS to Japanese quail(Coturnixjaponica),zebrafish(Brachydanio rerio)and freshwater shrimp(Macrobrachium nipponense)was assessed by estimations of LC5o or median lethal dose(LD5o).Results:In the laboratory,the LC5o values of 4%TDS for O.hupensis were 0.701,0.371 and 0.33 mg/L at 24,48 and 72 h,respectively,and 4%TDS showed a 0.33 mg/L 24 h LC5o against B.alexandrina,and a 1.396 mg/L 24 h LCs0 against B.truncatus.Across all study regions,the pooled mortalities of O.hupensis were 72,86,94 and 98%at 1,2,3 and 7 d,following field immersion of 4%TDS at a dose of 2.5 g/m3,and were 69,77,85 and 88%at 1,3,7 and 15 d,following field spraying at 5 g/m2,respectively.4%TDS had moderate toxicity to Japanese quail(7 d LD5o>60 mg/kg)and to shrimp(96 h LCs0=6.28 mg/L;95%CI:3.53-11.2 mg/L),whereas its toxicity to zebrafish was high(96 h LCso--0.15 mg/L;95%CI:0.14-0.17 mg/L).Conclusions:4%TDS is active against O.hupensis,B.alexandrina and B.truncatus under laboratory and field conditions,and it may be a candidate molluscicide of plant origin.

关键词： Schistosomiasis Luo-Wei Plant-derived molluscicide Oncomelania hupensis Biomphalaria alexandrina Bulinus truncatus molluscicidal activity

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Synthesis of New Fluorine/Phosphorus Substituted 6-(2’-Amino Phenyl)-3-Thioxo-1,2,4-Triazin-5(2H, 4H)One and Their Related Alkylated Systems as molluscicidal Agent as against the Snails Responsible for Bilharziasis Diseases

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International Journal of Organic Chemistry 2014年第2期4卷 154-168页

作者： Abeer N. Al-Romaizan Mohammed S. T. Makki Reda M. Abdel-Rahman Department of Chemistry Faculty of Science King Abdul Aziz University Jeddah KSA

New fluorine substituted 6-(5’-fluoro-2’-triphenylphosphiniminophenyl) 3-thioxo-1,2,4-triazin-5 (2H, 4H) one (2) was obtained via Wittig’s reaction of the corresponding 6-(5’-fluoro-2’-amino-phenyl)-3-thioxo-1,2,4-triazinone (1). Behavior of compound 2 towards alkylating agents and/or oxidizing agents was studied were, N-hydroxyl (3), Mannich base (4,5), S-alkyl (6,7,8) and thiazolo [3,2-b][1,2,4] triazinones (10-14) and or 3-disulfide (18), 3-sulfonic acid 19 and 1,2,4-triazin-3,5-Dionne (20) derivatives obtained. Structures of the new products are established by elemental and spectral data. The new targets obtained screened as molluscicidalagents against Biomophlaria Alexandrina snails responsible for Bilharziasis diseases, in compare with Baylucide as standard drug.

关键词： Fluorine Phosphorus Sulfur-1 2 4-Triazine Characteristic Properties molluscicidal Activity

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