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A Catalog of 13CO Clumps from the MWISP in l=10°–20°

Research in Astronomy and Astrophysics 2024年第5期24卷 218-234页

作者： Xiaoyu Luo Sheng Zheng Zhibo Jiang Zhiwei Chen Yao Huang Shuguang Zeng Xiangyun Zeng Rui Zhang Chen Long Guangrong Zhou Jinbo Hu Center for Astronomy and Space Sciences China Three Gorges UniversityYichang 443000China College of Electrical Engineering and New Energy China Three Gorges UniversityYichang 443000China College of Science China Three Gorges UniversityYichang 443000China Purple Mountain Observatory Chinese Academy of SciencesNanjing 210023China

In this study, we present a catalog of molecular clumps extracted from 13CO(J=1-0) emission data of the Milky Way Imaging Scroll Painting(MWISP) project. The data covers the inner Milky Way within the longitude range10°≤l≤20° and the latitude strip of |b|≤ 5°. 25. The workflow for the extraction of clumps, namely Facet-SS-3DClump, consists of two parts: the identification of clump candidates and their verification. First, Facet-SS-3DClump employs FacetClumps to identify clump candidates. Subsequently, high-confidence clumps are obtained by cross-matching with the clumps detected by other algorithms, such as dendrogram. Second, these high-confidence clumps are used as prior knowledge to train a semi-supervised deep clustering approach, SS-3D-Clump, which is applied to verify clump candidates detected by FacetClumps, providing confidence levels for the molecular clumps. Finally, the catalog comprising 18,757 molecular clumps was obtained using Facet-SS-3D-Clump, and the catalog is 90% complete above 37 K km s^(-1). We observe a significant deviation of the mean Galactic latitude for clumps within |b|≤ 2° from the midplane, with b=-0°.110. We found that 82.3% of the dust clumps correspond to 13CO clumps by matching with Herschel infrared dust clumps. In the future, Facet-SS-3D-Clump will be applied to detect 13CO clumps in the entire MWISP data.

关键词： ISM molecules methods data analysis-stars formation

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Targeted intelligent molecular generation framework based on fragments chemical space

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Huagong Xuebao/CIESC Journal 2024年第4期75卷 1655-1667页

作者： Wen, Huaqiang Sun, Quanhu Shen, Weifeng School of Chemistry and Chemical Engineering Chongqing University Chongqing 401331 China

Molecular generation has emerged as a cost-effective and rapid approach for advancing the design and optimization of solvents for separation, reaction, catalysts, functional materials, pharmaceuticals, and other molecules. Existing molecular generation models, mainly based on deep learning frameworks, suffer from limited transparency and struggle to explore local chemical spaces effectively. In this work, we propose a function-driven molecular intelligent generation framework based on molecular fragment chemical space. Using molecular functional indicators as the direction for generation, and the"scaffolds-decorations"set of generated molecules as the basis, this framework explored the molecular fragment chemical space to facilitate targeted molecule generation. In addition, by using the chemical space deconstruction model proposed in this work, new structures from neighboring chemical spaces of excellent molecular structures are derived, thus enriching the variety of new molecules. By demonstrating the generation of drug-like molecules as an example, this framework starts from a smaller set of excellent molecules (644) and ultimately generates five times more excellent molecules (3158) of the same level, which illustrates the framework ' s ability to efficiently evolve a multitude of novel and high-quality molecules on the basis of diverse samples. This framework can combine functional objectives and constraints in actual chemical processes to promote new optimal designs such as green solvents at the process scale. © 2024 Materials China. All rights reserved.

关键词： molecules

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The ALMA-QUARKS Survey.Ⅰ.Survey Description and Data Reduction

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Research in Astronomy and Astrophysics 2024年第2期24卷 104-124页

作者：刘训川 Tie Liu Lei Zhu Guido Garay Hong-Li Liu Paul Goldsmith Neal Evans Kee-Tae Kim Sheng-Yuan Liu Fengwei Xu Xing Lu Anandmayee Tej Xiaofeng Mai Leonardo Bronfman Shanghuo Li Diego Mardones Amelia Stutz Ken'ichi Tatematsu Ke Wang Qizhou Zhang Sheng-Li Qin Jianwen Zhou Qiuyi Luo Siju Zhang Yu Cheng Jinhua He Qilao Gu Ziyang Li Zhenying Zhang Suinan Zhang Anindya Saha Lokesh Dewangan Patricio Sanhueza Zhiqiang Shen Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China Chinese Academy of Sciences South America Center for Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China Departamento de Astronomía Universidad de ChileLas Condes7591245 SantiagoChile School of Physics and Astronomy Yunnan UniversityKunming 650091China Jet Propulsion Laboratory California Institute of Technology4800 Oak Grove DrivePasadena CA 91109USA Department of Astronomy The University of Texas at AustinTX 78712-1205USA Korea Astronomy and Space Science Institute 776 Daedeokdae-roYuseong-guDaejeon 34055Republic of Korea Institute of Astronomy and Astrophysics Academia SinicaRoosevelt RoadTaipei 10617China Kavli Institute for Astronomy and Astrophysics Peking UniversityBeijing 100871China Department of Astronomy School of PhysicsPeking UniversityBeijing 100871China Indian Institute of Space Science and Technology Thiruvananthapuram 695547KeralaIndia Max Planck Institute for Astronomy Königstuhl 17D-69117 HeidelbergGermany Departamento de Astronomía Universidad de ConcepciónCasilla 160-CConcepciónChile Nobeyama Radio Observatory National Astronomical Observatory of JapanNational Institutes of Natural Sciences462-2 NobeyamaMinamimakiMinamisakuNagano 384-1305Japan Center for Astrophysics∣Harvard&Smithsonian 60 Garden StreetCambridgeMA 02138USA Max-Planck-Institut für Radioastronomie Auf dem Hügel 69D-53125 BonnGermany School of Astronomy and Space Sciences University of Chinese Academy of SciencesBeijing 100049China National Astronomical Observatory of Japan 2-21-1 OsawaMitakaTokyo181-8588Japan Yunnan Observatories Chinese Academy of SciencesKunming 650216China Physical Research Laboratory NavrangpuraAhmedabad-380009India Astronomical Science Program The Graduate University for Advanced StudiesSOKENDAI2-21-1 OsawaMitakaTokyo 181-8588Japan University of Science and Technology Korea(UST)217 Gajeong-roYuseong-guDaejeon 34113Republic o

This paper presents an overview of the QUARKS survey,which stands for Querying Underlying mechanisms of massive star formation with ALMA-Resolved gas Kinematics and Structures."The QUARKS survey is observing139 massive clumps covered by 156 pointings at Atacama Large Millimeter/submillimeter Array(ALMA)Band 6(λ~1.3 mm).In conjunction with data obtained from the ALMA-ATOMS survey at Band 3(λ~3 mm),QUARKS aims to carry out an unbiased statistical investigation of massive star formation process within protoclusters down to a scale of 1000 au.This overview paper describes the observations and data reduction of the QUARKS survey,and gives a first look at an exemplar source,the mini-starburst Sgr B2(M).The wide-b and width(7.5 GHz)and high-angular-resolution(~0."3)observations of the QUARKS survey allow for the resolution of much more compact cores than those could be done by the ATOMS survey,and to detect previously unrevealed fainter filamentary structures.The spectral windows cover transitions of species including CO,SO,N_(2)D^(+),SiO,H_(30)α,H_(2)CO,CH_(3)CN,and many other complex organic molecules,tracing gas components with different temperatures and spatial extents.QUARKS aims to deepen our understanding of several scientific topics of massive star formation,such as the mass transport within protoclusters by(hub-)filamentary structures,the existence of massive starless cores,the physical and chemical properties of dense cores within protoclusters,and the feedback from already formed high-mass young protostars.

关键词： stars formation-stars kinematics and dynamics-ISM clouds-ISM molecules

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Recent Progress in the Biological Basis of Remodeling Tissue Regeneration Using Nanofibers:Role of Mesenchymal Stem Cells and Biological molecules

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Journal of Bionic Engineering 2019年第2期16卷 189-208页

作者： Roqia Ashraf Hasham S.Sofi Hern Kim Faheem A.Sheikh Department of Nanotechnology University of KashmirHazratbalSrinagar-190006Jammu and KashmirIndia Department of Energy Science and Technology Fusion Smart Living Innovation Technology CenterMyongji UniversityYon ginKyonggi-do 17058Republic of Korea

Opening up new and unlimited avenues in the biomedical field,tissue engineering and regenerative medicine,the electrospinning process is considered as a versatile and the most preferred technique for the fabrication of nanofibers.These tailor-designed nanofibers provide a desirable and bio-inspired physiological niche to cells for better attachment and subsequent proliferation.In this review,an attempt is made to explain the importance of various topological and morphological parameters of nanofibrous scaffolds for efficient bio-mimicking.Some novel approaches(e.g.,appropriate functionalization and extracellular matrix derived from decellularization)utilized for better mimicking and exponential growth of regenerating tissues are also discussed.Furthermore,this review highlights the important parameters necessary for the attachment,proliferation and differentiation of the mesenchymal stem cells for tissue regeneration.The importance of growth factors and their role after introducing the electrospinning techniques for efficient delivery and their role in the proliferation of mesenchymal stem cells in the different specific lineage(e.g.,tenogenic,chondrogenic,neurogenic and osteogenic differentiation)are discussed.

关键词： electrospinning nanofibers bio-mimicking stem cells bioactive molecules regenerative medicine

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Recent progress on signalling molecules of coral-associated microorganisms

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Science China Earth Sciences 2019年第4期62卷 609-618页

作者： Kaihao TANG Yan WANG Xiaoxue WANG Key Laboratory of Tropical Marine Bio-resources and Ecology South China Sea Institute of Oceanology Chinese Academy of Sciences Ocean College Hainan University University of Chinese Academy of Sciences

Coral reefs have high primary productivity and are one of the most important ecosystems in the ocean. However, the health and stability of coral reefs are constantly threatened by climate change and human activities. The coral holobiont is a complex symbiosis between the coral animal, zooxanthellae, and the associated community of microorganisms including bacteria, archaea, viruses, etc. Coral-associated microorganisms are found to be important for the maintenance of coral health,and they are proposed to contribute to the acclimatization and adaptation of reef-building corals under rapid climate change. The coral-microbe interaction mediated by chemical signalling molecules is an important driving force for shaping the microbial communities. Herein, we summarize our current knowledge of the chemical signalling molecules involved in the interaction of the coral holobiont. Specifically, the cooperation and competition among microbes mediated by N-acyl homoserine lactones(AHLs), the interrelationship between microbes and hosts mediated by dimethylsulfoniopropionate(DMSP) and nitric oxide(NO), and the response of corals and microorganisms to reactive oxygen species(ROS) under environmental stresses are highlighted in this review. We further discuss the potential of manipulating the coral microbiome using signalling molecules to restore and protect coral reefs.

关键词： Reef-building coral Coral-associated microorganisms Coral microbiome Signalling molecules Quorum sensing DMSP

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Structural immunology of costimualtory and coinhibitory molecules

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Science China(Life Sciences) 2010年第2期53卷 183-189页

作者： WANG ShengDian1 & CHEN LiePing1,2 1Center for Infection and Immunity,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China 2Department of Oncology,Johns Hopkins University School of Medicine,Baltimore,Maryland,USA Center for Infection and Immunity Institute of Biophysics Chinese Academy of Sciences Beijing China Department of Oncology Johns Hopkins University School of Medicine Baltimore USA

The T cell costimulatory pathways are central to regulating immune responses,and targeting these pathways represents one of the most promising approaches for achieving immunotherapy.The molecular structures of costimulation revealed invaluable mechanistic insights underlying costimulatory receptor/ligand specificity,affinity,oligomeric state,and valency,which provided the bases for better manipulation of these signaling pathways.The incredible growth of this field led to identification of new members and unexpected interactions,revealing a complicated regulatory network of immune responses.The advances in structural biology of costimulation will promise unprecedented opportunities for furthering our understanding and therapeutic application of T cell costimulatory pathways.

关键词： costimulatory molecules T cells molecular structure immunotherapy

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Small molecules for mesenchymal stem cell fate determination

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World Journal of Stem Cells 2019年第12期11卷 1084-1103页

作者： Yu-Hao Cheng Jing-Cheng Dong Qin Bian Institute for Cell Engineering Johns Hopkins University School of MedicineBaltimoreMD 21205United States Department of Integrative Medicine Huashan HospitalFudan UniversityShanghai 200040China

Mesenchymal stem cells(MSCs)are adult stem cells harboring self-renewal and multilineage differentiation potential that are capable of differentiating into osteoblasts,adipocytes,or chondrocytes in vitro,and regulating the bone marrow microenvironment and adipose tissue remodeling in vivo.The process of fate determination is initiated by signaling molecules that drive MSCs into a specific lineage.Impairment of MSC fate determination leads to different bone and adipose tissue-related diseases,including aging,osteoporosis,and insulin resistance.Much progress has been made in recent years in discovering small molecules and their underlying mechanisms control the cell fate of MSCs both in vitro and in vivo.In this review,we summarize recent findings in applying small molecules to the trilineage commitment of MSCs,for instance,genistein,medicarpin,and icariin for the osteogenic cell fate commitment;isorhamnetin,risedronate,and arctigenin for pro-adipogenesis;and atractylenolides and dihydroartemisinin for chondrogenic fate determination.We highlight the underlying mechanisms,including direct regulation,epigenetic modification,and post-translational modification of signaling molecules in the AMPK,MAPK,Notch,PI3K/AKT,Hedgehog signaling pathways etc.and discuss the small molecules that are currently being studied in clinical trials.The target-based manipulation of lineage-specific commitment by small molecules offers substantial insights into bone marrow microenvironment regulation,adipose tissue homeostasis,and therapeutic strategies for MSC-related diseases.

关键词： Mesenchymal stem cell Mesenchymal stromal cell Cell fate determination Small molecules Natural compounds Signaling pathways

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HELMHOLTZ FREE ENERGY IN A SYSTEM OF ANISOTROPIC CHAINLIKE molecules AND ITS APPLICATIONS FOR NORMAL MONOHYDRIC ALCOHOLS AND NORMAL ALKANES

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Chinese Journal of Chemical Engineering 1997年第2期5卷 91-100页

作者：丛威陆九芳李以圭 Department of Chemical Engineering Tsinghua University

1 INTRODUCTIONAfter Prausnitz et al.published the perturbed hard-sphere chain theory(PHCT),manymodified theories have been put forward,such as the perturbed soft-sphere chain theory(PSCT),the perturbed anisotropic chain theory(PACT)and the associated perturbedanisotropic chain theory(APACT).These theories are all concerned with the parameter3c.But,Wertheim in his work proved that the free energy of hard-sphere chain couldbe calculated without 3c.Induced by the work done by Wertheim,Chapman

关键词： perturbation theory chainlike molecules Helmholtz free energy normal monohydric alco-hol normal alkane

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Field-Free Orientation of molecules with Small Permanent Dipole Moments by Using a Train of Half-Cycle Pulses

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Chinese Physics Letters 2005年第3期22卷 576-579页

作者：池方萍陈基根陈高杨玉军都文和朱海燕朱颀人 InstituteofAtomicandMolecularPhysics JilinUniversityChangchun130012

We present a scheme aiming at the field-free orientation of molecules with smaller permanent dipole moments under the framework of the half-cycle pulse (HCP) method. Taking the HCCCl molecule as an example, we show that a train of identical HCPs with special time intervals can considerably raise the level of the orientation. The scheme is analytically interpreted in terms of intermittent Rabi oscillations by referring to a simplified two-state model.

关键词： Field-Free Orientation molecules Small Permanent Dipole Moments Half-Cycle Pulses

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Continuum Structures at the Second Dissociation Limit of Hydrogen molecules

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Chinese Physics Letters 2005年第5期22卷 1114-1117页

作者：张彦鹏甘琛利宋建平余孝军马瑞琼葛浩姜彤卢克清 E.E.Eyler DepartmentofElectronicScienceandTechnology Xi'anJiaotongUniversityXi'an710049 DepartmentofPhysics Universityo-fNorthTexasDentonPOBox311427TX76203-1427USA StateKeyLaboratoryofTransientOpticsandTechnology Xi'anInstituteofOpticsandPrecisionMechanicsChineseAcademyofSciencesXi'an710068 DepartmentofPhysics UniversityofConnecticutU-3046StorrsConnecticut06269USA DepartmentofElectronicScienceandTechnology Xi'anJiaotongUniversityXi'an710049

We describe near-threshold high-resolution spectra and continuum resonance dynamical behaviour of all three stable hydrogen isotopic variants, and finally obtain improved values for the dissociation energies of hydrogen molecule and its ion. The second dissociation limit is determined by analysing the onset of the vibrational continuum.

关键词： molecules

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