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Role of molecular imaging in prognosis,diagnosis,and treatment of gastrointestinal cancers:An update on new therapeutic methods

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World Journal of Methodology 2024年第4期14卷 43-60页

作者： Mobina Fathi Hayder Jasim Taher Sabah Jassim Al-Rubiae Shirin Yaghoobpoor Ashkan Bahrami Reza Eshraghi Hossein Sadri Mahsa Asadi Anar Ali Gholamrezanezhad Student Research Committee School of MedicineShahid Beheshti University of Medical SciencesTehran ***Iran Department of Radiology Hilla University CollegeBabylon 00964Iraq Faculty of Medicine Kashan University of Medical SciencesKashan ***Iran Department of Radiology Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90033United States

One of the leading causes of cancer-related death is gastrointestinal cancer,which has a significant morbidity and mortality *** preoperative risk assessment is essential for directing patient care,its biological behavior cannot be accurately predicted by conventional imaging *** pathophysiological information in anatomical imaging that cannot be visually identified can now be converted into high-dimensional quantitative image features thanks to the developing discipline of molecular *** order to enable molecular tissue profile in vivo,molecular imaging has most recently been utilized to phenotype the expression of single receptors and targets of biological *** is expected that molecular imaging will become increasingly important in the near future,driven by the expanding range of biological therapies for *** this live molecular fingerprinting,molecular imaging can be utilized to drive expression-tailored customized *** technical aspects of molecular imaging are first briefly discussed in this review,followed by an examination of the most recent research on the diagnosis,prognosis,and potential future clinical methods of molecular imaging for GI tract malignancies.

关键词： molecular imaging Personalized medicine Gastrointestinal cancers Positron emission tomography-computed tomography

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Diffusion magnetic resonance imaging: A molecular imaging tool caught between hope, hype and the real world of “personalized oncology”

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World Journal of Radiology 2017年第6期9卷 253-268页

作者： Abhishek Mahajan Sneha S Deshpande Meenakshi H Thakur Department of Radiodiagnosis and imaging Tata Memorial Hospital Tata Memorial Centre Department of Radiodiagnosis and imaging Tata Memorial Centre

"Personalized oncology" is a multi-disciplinary science, which requires inputs from various streams for optimal patient management. Humongous progress in the treatment modalities available and the increasing need to provide functional information in addition to the morphological data; has led to leaping progress in the field of imaging. Magnetic resonance imaging has undergone tremendous progress with various newer MR techniques providing vital functional information and is becoming the cornerstone of "radiomics/radiogenomics". Diffusionweighted imaging is one such technique which capitalizes on the tendency of water protons to diffuse randomly in a given system. This technique has revolutionized oncological imaging, by giving vital qualitative and quantitative information regarding tumor biology which helps in detection, characterization and post treatment surveillance of the lesions and challenging the notion that "one size fits all". It has been applied at various sites with different clinical experience. We hereby present a brief review of this novel functional imaging tool, with its application in "personalized oncology".

关键词： Functional magnetic resonance imaging molecular imaging Diffusion-weighted imaging Tumor biology Biomarker Radiomics

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Role of molecular imaging in the management of patients affected by inflammatory bowel disease:State-of-the-art

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World Journal of Radiology 2016年第10期8卷 829-845页

作者： Federico Caobelli Laura Evangelista Natale Quartuccio Demetrio Familiari Corinna Altini Angelo Castello Mariapaola Cucinotta Rossella Di Dato Cristina Ferrari Aurora Kokomani Iashar Laghai Riccardo Laudicella Silvia Migliari Federica Orsini Salvatore Antonio Pignata Cristina Popescu Erinda Puta Martina Ricci Silvia Seghezzi Alessandro Sindoni Martina Sollini Letterio Sturiale Anna Svyridenka Vittoria Vergura Pierpaolo Alongi Department of Nuclear Medicine Universitatsspital Basel Department of Nuclear Medicine Istituto Oncologico Veneto Wolfson molecular imaging Centre Univer-sity of Manchester Department of Nuclear Medicine A.R.N.A.S. Nuclear Medicine Unit Univer-sity"Aldo Moro"of Bari Department of Nuclear Medicine University of Florence Department of medical-surgical science and translational medicine "La Sapienza"University Nuclear Medicine Unit Department of Biomedical Sciences and Morphological and Functional ImagesUniversity of Messina Department of Nuclear Medicine University of Parma Department of Nuclear Medicine University Hospital"Maggiore della Carita di Novara" Department of Nuclear Medicine Niguarda Ca'Grande Hospital Department of Nuclear Medicine Hospital of Treviglio Humanitas University Department of Nuclear Medicine University of Bologna Nuclear Medicine Unit Department of Radio-logical SciencesG.Giglio Institute

AIM To present the current state-of-the art of molecular imaging in the management of patients affected by inflammatory bowel disease(IBD).METHODS A systematic review of the literature was performed in order to find important original articles on the role of molecular imaging in the management of patients affected by IBD. The search was updated until February 2016 and limited to articles in *** Fifty-five original articles were included in this review, highlighting the role of single photon emission tomography and positron emission tomography. CONCLUSION To date, molecular imaging represents a useful tool to detect active disease in IBD. However, the available data need to be validated in prospective multicenter studies on larger patient samples.

关键词： White blood cell scintigraphy Inflammatory bowel disease Inflammation ^(18)F-Fluorodehoxiglucose positron emission tomography/computed tomography molecular imaging

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Liver Protective and ROS Scavenging Effects of Emodin in LPS/BCG-injured Mice by Optical molecular imaging Running Title:Emodin Scavenges ROS and Protects Liver

Liver Protective and ROS Scavenging Effects of Emodin in LPS...

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第十四届全国中药和天然药物学术研讨会

作者： Na Li Jia-bo Wang Yan-ling Zhao Lin Zhang Xi-bo Ma Feng-yi Li Ya-ming Zhang Xiao-fei Li Can Tu Chun-yu Li Jing-yao Pang Ge-liuchang Jia Dan Yan Xin Yang Ting-guo Kang Jie Tian Xiao-he Xjao Liaoning University of Traditional Chinese Medicine 302 Military Hospital Chinese Academy of Sciences Shandong University of Traditional Chinese Medicine Hunan University of Chinese Medicine Capital Medical University

Aim Hepatocytes damage is sometimes closely related to oxidative stress and reactive oxygen species（ROS） which are the major contributors to lipopolysaccharide（LPS）-induced liver ***,the active natural product in rhubarb of hydroxyanthraquinone skeleton,has been reported of protective activity to liver tissue,whose mechanism is generally thought of antioxidation based on chemical reaction or indirect *** is no visualized evidence proved the ROS scavenging effect of emodin in *** The in vivo ROS scavenging effect of emodin by using the optical molecular imaging approach to monitor the dynamic ROS luminescent signal in mice injured by Bacillus Calmette Guerin（BCG） and *** The elevations of serum alanine aminotransferase and aspartate transaminase activities in BCG/LPS-injured mice were reversed by emodin,indicating the protection of emodin to *** emodin significantly and dose-dependently attenuated the ROS luminescent signal elicited by BCG/LPS,indicating visually the in vivo ROS scavenging effect of *** addition,emodin significantly and dose-dependently elevated the activity of superoxide dismutase,content of reduced glutathione and total antioxidant capacity,and meanwhile decreased the contents of hydrogen peroxide,lipid peroxides and malondialdehyde in livers of BCG/LPS-injured *** could be attributed to the anti-oxidative effect of emodin which helps to maintain the ROS balance in *** Emodin can protect liver against LPS/BCG induced injury and the mechanism includes ROS scavenging effect and anti-lipid peroxidation at least.

关键词： emodin hepatoprotection reactive oxygen species molecular imaging lipopolysaccharide.

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Tracking of Labelled Stem Cells Using molecular MR imaging in a Mouse Burn Model <i>in Vivo</i>as an Approach to Regenerative Medicine

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Advances in molecular imaging 2021年第1期11卷 1-15页

作者： Zeba Qadri Valeria Righi Shasha Li A. Aria Tzika MGH NMR Surgical Laboratory Center for Surgery Innovation and Bioengineering Department of Surgery Massachusetts General and Shriners Burn Hospitals Harvard Medical School Boston USA Athinoula A. Martinos Center of Biomedical imaging Department of Radiology Massachusetts General Hospital Harvard Medical School Charlestown USA

Therapies based on stem cell transplants offer significant potential in the field of regenerative medicine. Monitoring the fate of the transplanted stem cells in a timely manner is considered one of the main limitations for long-standing success of stem cell transplants. imaging methods that visualize and track stem cells in vivo non-invasively in real time are helpful towards the development of successful cell transplantation techniques. Novel molecular imaging methods which are non-invasive particularly such as MRI have been of great recent interest. Hence, mouse models which are of clinical relevance have been studied by injecting contrast agents used for labelling cells such as super-paramagnetic iron-oxide (SPIO) nanoparticles for cellular imaging. The MR techniques which can be used to generate positive contrast images have been of much relevance recently for tracking of the labelled cells. Particularly when the off-resonance region in the vicinity of the labeled cells is selectively excited while suppressing the signals from the non-labeled regions by the method of spectral dephasing. Thus, tracking of magnetically labelled cells employing positive contrast in vivo MR imaging methods in a burn mouse model in a non-invasive way has been the scope of this study. The consequences have direct implications for monitoring labeled stem cells at some stage in wound healing. We suggest that our approach can be used in clinical trials in molecular and regenerative medicine.

关键词： Burn Wounds Cell Labeling Cell Tracking Cellular imaging Magnetic Resonance imaging (MRI) molecular imaging Positive Contrast imaging Stem Cells

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A New Generation of Semiconductor Quantum Dots for molecular and Cellular imaging

A New Generation of Semiconductor Quantum Dots for Molecular...

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第十一次中国生物物理学术大会暨第九届全国会员代表大会

作者： Andrew M.Smith Mary Wen Departments of Biomedical Engineering and Chemistry Emory University

＜正＞Semiconductor quantum dots,tiny light-emitting particles on the nanometer scale,are emerging as a new class of fluorescent labels for a broad range of molecular and cellular

关键词： Quantum Dot fluorescent label molecular imaging

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Simple and Specific molecular probes for imaging Gene Expression and Bacterial Function

Simple and Specific Molecular probes for Imaging Gene Expres...

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中国化学会第27届学术年会

作者： Shao Qing, Yanmei Yang, Bengang Xing* Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 637371, Singapore

＜正＞Biological specificity is mediated by the precise and selective regulation of gene expression in response to intrinsic development programs and extrinsic signals. In order to understand the regulation of gene

关键词： molecular imaging gene expression bacterial function

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A switch-on molecular biosensor for detection of caspase-3 and imaging of apoptosis of cells

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Science China(Life Sciences) 2022年第3期65卷 540-549页

作者： Rui Gong Dianbing Wang Ghulam Abbas Shimin Li Qian Liu Mengmeng Cui Xian-En Zhang National Laboratory of Biomacromolecules CAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Faculty of Synthetic Biology Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

Apoptosis is a form of programmed cell death that is essential for maintaining internal environmental *** apoptosis can cause a variety of diseases;therefore,sensing apoptosis can provide help in study of mechanism of the relevant diseases and drug *** is known that caspase-3 is a key enzyme involved in apoptosis and the expression of its activity is an indication of ***,we present a genetically encoded switch-on m Neon Green2-based molecular biosensor.m Neon Green2 is the brightest monomeric green fluorescent *** substrate of caspase-3,DEVD amino acid residues,is inserted in it,while cyclized by insertion of Nostoc punctiforme Dna E intein to abolish the fluorescence(inactive state).Caspase-3-catalyzed cleavage of DEVD linearizes m Neon Green2 and rebuilds the natural barrel structure to restore the fluorescence(activated state).The characterization exhibited that the Caspase-3 biosensor has shortened response time,higher sensitivity,and prolonged functional shelf life in detection of caspase-3 amongst the existing *** also used the Caspase-3 biosensor to evaluate the effect of several drugs on the induction of apoptosis of He La and MCF-7 tumor cells and inhibition of Zika virus invasion.

关键词： apoptosis caspase-3 molecular biosensor molecular imaging Zika virus

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imaging RNA IN LIVING CELLS WITH molecular BEACONS:CURRENT PERSPECTIVES AND CHALLENGES

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Journal of Innovative Optical Health Sciences 2009年第4期2卷 315-324页

作者： ANTONY K.CHEN ANDREW TSOURKAS Department of Bioengineering University of Pennsylvania PhiladelphiaPA 19104USA

There is a growing realization that cell-to-cell variations in gene expression have importantbiological consequences underlying phenotype diversity and cell fate. Although analytical toolsfor measuring gene expression, such as DNA microarrays, reverse-transcriptase PCR and in situhybridization have been widely utilized to discover the role of genetic variations in governingcellular behavior, these methods are performed in cell lysates and/or on fixed cells, and thereforelack the ability to provide comprehensive spatial-dynamic information on gene expression. Thishas invoked the recent development of molecular imaging strategies capable of illuminatingthe distribution and dynamics of RNA molecules in living cells. In this review, we describe aclass of molecular imaging probes known as molecular beacons (MBs), which have increasinglybecome the probe of choice for imaging RNA in living cells. In addition, we present the majorchallenges that can limit the ability of MBs to provide accurate measurements of RNA, anddiscuss efforts that have been made to overcome these challenges. It is envisioned that withcontinued refinement of the MB design, MBs will eventually become an indispensable tool foranalyzing gene expression in biology and medicine.

关键词： Gene expression fluorescence probes molecular imaging biosensor

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Bi-specific T1 positive-contrast-enhanced magnetic resonance imaging molecular probe for hepatocellular carcinoma in an orthotopic mouse model

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World Journal of Gastrointestinal Oncology 2022年第4期14卷 858-871页

作者： Xiao-Hong Ma Kun Chen Shuang Wang Si-Yun Liu Deng-Feng Li Yong-Tao Mi Zhi-Yuan Wu Chun-Feng Qu Xin-Ming Zhao Diagnostic Radiology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China State Key Laboratory of molecular Oncology National Cancer Center/Cancer HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100021China GE Healthcare(China) Beijing 100176China

BACKGROUND Hepatocellular carcinoma(HCC)is the second leading cause of cancer-related ***-targeted magnetic resonance imaging(MRI)is an effective noninvasive diagnostic method that involves targeting clinically-related HCC biomarkers,such as alpha-fetoprotein(AFP)or glypican-3(GPC3),with iron oxide ***,in vivo studies of HCC-targeted MRI utilize single-target iron oxide nanoprobes as negative(T2)contrast agents,which might weaken their future clinical applications due to tumor heterogeneity and negative MRI ***-small superparamagnetic iron oxide(USPIO)nanoparticles(approximately 5 nm)are potential optimal positive(T1)contrast *** previously verified the efficiency of AFP/GPC3-double-antibody-labeled iron oxide MR molecular probe in *** To validate the effectiveness of a bi-specific probe in vivo for enhancing T1-weighted positive contrast to diagnose the early-stage *** The single-and double-antibody-conjugated 5-nm USPIO probes,including antiAFP-USPIO(UA),anti-GPC3-USPIO(UG),and anti-AFP-USPIO-anti-GPC3(UAG),were synthesized.T1-and T2-weighted MRI were performed on day 10 after establishment of the orthotopic HCC mouse *** intravenous injection of U,UA,UG,and UAG probes,T1-and T2-weighted images were obtained at 12,12,and 32 h *** the end of scanning,mice were euthanized,and a histologic analysis was performed on tumor *** T1-and T2-weighted MRI showed that absolute tumor-to-background ratios in UAG-treated HCC mice peaked at 24 h post-injection,with the T1-and T2-weighted signals increasing by 46.7%and decreasing by 11.1%,respectively,relative to pre-injection ***,T1-weighted contrast in the UAG-treated group at 24 h post-injection was enhanced 1.52-,2.64-,and 4.38-fold compared to those observed for single-targeted anti-GPC3-USPIO,anti-AFP-USPIO,and nontargeted USPIO probes,*** of U-,UA-,UG-,and UAG-treated tumor sections revealed t

关键词： Hepatocellular carcinoma molecular imaging Magnetic resonance imaging Positive contrast agent Alpha-fetoprotein Glypican-3

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