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Britton Chance's lab and thereafter:From NIR spectroscopy to molecular sensing via nanotechnology

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Journal of Innovative Optical Health Sciences 2014年第2期7卷 1-11页

作者： Kyung.A.Kang Department of Chemical Engineering University of Louisvile Louisvile KY 40292USA

I was fortunate to,work with/for Dr Britton Chance as his postdoctoral fellow,in the Bio-chemistry and Biophysics Department at the University of Pennsy lvania,bet ween August 1991and January *** anyone who worked for him,I had a suficient dosage of"Brtton Chance"over the ***,to me,I felt that he was someone who was above regular people and faraway to reach,Then I became to know him as a person,who was simple and complicated at thesame time,with a persistent pursuit for his life interests,i.e,the advancement in science relatedto human *** far as it goes to science(and perhaps with sailing),he had few boundary:Hecommunicated with any age group,any one from any country with any cultural *** were welcomed to his lab,his own house,and even his *** was happy with minimalmaterial *** kept his friendship *** him,I came to lmow how much oneperson can actually do during a life *** very gratefil that I got to lnow him during my lifepath In this paper,list some of my experiences with hin scientifically and also how and what ilearned from him impacted my research and personal life.

关键词： Biosensing molecular sensing contrast agent Nanopartidles cancer detection.

Molybdenum disulfide-graphene van der Waals heterostructures as stable and sensitive electrochemical sensing platforms

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Tungsten 2020年第4期2卷 411-422页

作者： Stelbin Peter Figerez Kiran Kumar Tadi Krishna Rani Sahoo Rahul Sharma Ravi K.Biroju Aleena Gigi KAiswarya Anand Golap Kalita Tharangattu N.Narayanan Tata Institute of Fundamental Research Hyderabad 500046India Division of Healthcare Advancement Innovation and ResearchVellore Institute of Technology(VIT)Chennai 600127India Department of Physical Science and Engineering Nagoya Institute of TechnologyNagoya 466‑8555Japan

Atomic layers are sought after for molecular sensing due to their available high surface interaction area,and different types of monolayers are attempted for sensing in the recent ***,their chemical stability towards these molecules is questioned in recent times and alternate methods need to be developed to circumvent such issues,while maintaining high ***,the van der Waals(vdWs)stacks of molybdenum disulfide(MoS_(2))and graphene are shown for their stable electrochemical sensing towards ascorbic acid(AA)and dopamine(DA)-two important *** is known to chemically react with MoS_(2) leading to unstable sensing platform,while here the graphene coverage is shown to protect the MoS_(2) even from low-energy plasma exposure while keeping the same high *** proving the graphene-based protection of the sensor,such a sensing platform is shown for its applicability in DA sensing,where it is found to give a linear response in a wide range of concentrations(2.5 to 600μmol·L^(−1))and even selective sensing in the presence of *** a stack is found to be not merely giving protection to the beneath MoS_(2) layer but also the inter-layer charge transfer due to work function differences being beneficial in bringing fast and high sensitivity to the next-generation sensors and point-of-care devices.

关键词： Graphene molecular sensing MoS_(2)etching MoS_(2)protection van der Waals structures Electrochemical sensing Ascorbic acid Dopamine

Competitive aptamer switch for modulating ligand binding affinity

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Advanced Agrochem

Advanced Agrochem 2023年第3期2卷 264-268页

作者： Derek Puyat Sung Won Oh Shiming Liu Jinglin Fu Department of Chemistry Rutgers University-Camden201 BroadwayCamdenNJ08102USA Center for Computational and Integrative Biology Rutgers University-Camden201 BroadwayCamdenNJ08102USA

Aptamers are short,single-stranded DNA or RNA molecules that selectively bind to a target *** duplex(ACD)is often used to design molecular switches capable of producing a detectable signal or triggering a structural change upon aptamer binding to a ***,such aptamer switch generally faces an increased dissociation constant(Kd)due to the energy barrier of the complementary *** reported a competitive hybridization mechanism to modulate the binding affinity of an ACD to a target *** the computation-guided design,we calculated the aptamer folding energy for the duplex length from 11-nt to 15-nt,and experimentally measured increased apparent Kd values resulted from these extended *** a set of strands to compete with the ACD hybridization,it reduced the aptamer folding energy to facilitate aptamer switches with decreased apparent Kd values ranging from over 400μM without a competing strand to~30μM with a competing *** competitive aptamer switch was also found sensitive to single-nucleotide mutations of a competing *** work provides an approach to modulate the binding affinity and the sensitivity of aptamer-complement duplexes,which could be useful in the nucleic acids-based sensing and nanomedicine.

关键词： Aptamer-complement duplex Aptamer switches Competitive hybridization molecular sensing

Dynamic photonic barcodes for molecular detection based on cavity-enhanced energy transfer

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Advanced Photonics 2020年第6期2卷 69-77页

作者： Yunke Zhou Zhiyi Yuan Xuerui Gong Muhammad D.Birowosuto Cuong Dang Yu-Cheng Chen Nanyang Technological University School of Electrical and Electronic EngineeringSingapore CINTRA UMI CNRS/NTU/THALES Singapore Nanyang Technological University School of Chemical and Biomedical EngineeringSingapore

Optical barcodes have demonstrated a great potential in multiplexed bioassays and cell tracking for their distinctive spectral *** vast majority of optical barcodes were designed to identify a specific target by fluorescence emission spectra,without being able to characterize dynamic changes in response to analytes through *** overcome these limitations,the concept of the bioresponsive dynamic photonic barcode was proposed by exploiting interfacial energy transfer between a microdroplet cavity and binding ***-gallery modes resulting from cavity-enhanced energy transfer were therefore converted into photonic barcodes to identify binding activities,in which more than trillions of distinctive barcodes could be generated by a single *** spectral barcoding was achieved by a significant improvement in terms of signal-to-noise ratio upon binding to target *** studies and experiments were conducted to elucidate the effect of different cavity sizes and analyte *** fluorescence lifetime was implemented to investigate the role of radiative and non-radiative energy ***,microdroplet photonic barcodes were employed in biodetection to exhibit great potential in fulfilling biomedical applications.

关键词： whispering-gallery modes optical barcodes fluorescence resonance energy transfer molecular sensing biointerface cavity-enhancement

A Two-Fold Interpenetrating Porous Metal–Organic Framework with Large Solvent-Accessible Volume: Gas Sorption and Luminescent Properties

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A Two-Fold Interpenetrating Porous Metal–Organic Framework ...