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A boronate-based modular assembly nanosystem to block the undesirable crosstalk between hepatic stellate cells and Kupffer cells

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Bioactive Materials 2023年第7期25卷 569-579页

作者： Huizhen Jia Ling Ding Ao Yu Weimin Tang Siyuan Tang Chuhan Zhang David Oupický Center for Drug Delivery and Nanomedicine Department of Pharmaceutical SciencesCollege of PharmacyUniversity of Nebraska Medical CenterOmahaNE68198USA

Crosstalk between Kupffer cells(KCs)and hepatic stellate cells(HSCs)plays an important role in multiple liver disease conditions,including the formation of liver fibrosis in alcohol-associated liver disease(AALD).Therapeutic targeting of the KC-HSC crosstalk is a prime target for therapeutic ***,a novel modular nanosystem was designed and prepared through the self-assembly utilizing boric acid and catechol interactions to prepare polymers modified with a CXCR4-inhibiting *** polymers were used to encapsulate anti-miR-155 and to block the undesirable crosstalk between HSCs and KCs by downregulating miR-155 expression in KCs with the parallel inhibition of CXCR4 signaling in activated *** combined inhibition of miR-155 and CXCR4 at two different liver cell types achieved improved antifibrosis effects in a mouse model of AALD *** finding highlights the key role that blocking the undesirable crosstalk between HSCs and KCs plays in reversing AALD fibrosis as well as demonstrates a proof-of-concept approach for designing and constructing multifunctional delivery nanosystems using orthogonal functional modules based on the understanding of disease mechanisms.

关键词： Nanoparticles miRNA CXCR4 Liver fibrosis Undesirable crosstalk modular assembly

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Biofabrication strategies with single-cell resolution: a review

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International Journal of Extreme Manufacturing 2023年第4期5卷 120-148页

作者： Dezhi Zhou Bohan Dou Florian Kroh Chuqian Wang Liliang Ouyang Department of Mechanical Engineering Tsinghua UniversityBeijing 100084People’s Republic of China Biomanufacturing and Rapid Forming Technology Key Laboratory of Beijing Tsinghua UniversityBeijing 100084People’s Republic of China ‘Biomanufacturing and Engineering Living Systems’Innovation International Talents Base(111 Base) Tsinghua UniversityBeijing 100084People’s Republic of China

The introduction of living cells to manufacturing process has enabled the engineering of complex biological tissues in *** recent advances in biofabrication with extremely high resolution(*** single cell level)have greatly enhanced this capacity and opened new avenues for tissue *** this review,we comprehensively overview the current biofabrication strategies with single-cell resolution and categorize them based on the dimension of the single-cell building blocks,***-dimensional single-cell droplets,one-dimensional single-cell filaments and two-dimensional single-cell *** provide an informative introduction to the most recent advances in these approaches(*** trapping,bioprinting,electrospinning,microfluidics and cell sheets)and further illustrated how they can be used in in vitro tissue modelling and regenerative *** highlight the significance of single-cell-level biofabrication and discuss the challenges and opportunities in the field.

关键词： cellular building block modular assembly single-cell resolution in vitro model regenerative medicine

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