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The effect of modified wen-dan decoction on hippocampal astrocytes in depression model rats

TMR Pharmacology Research 2021年第3期1卷 41-47页

作者： Li-Ping Zhang Shen-jun Wang Ting Xue Lei Xu Yun-Sha Zhang Ying Chen Jun Yang Rui-wen Song Xue-Yan Wang Tianjin University of Chinese Medicine TianjinChina301617

Background:This study aimed to observe the effect of modified wen-dan decoction on hippocampal astrocytes in depression model ***:A total of 48 rats were randomly divided into a control group,a model group,a modified wen-dan decoction group(referred toas the traditional Chinese medicine group),and a fluoxetine control group(referred to as the Western medicine group).The control group was provided with a free diet and without any stimulation,while the remaining three groups were solitarily housed incombination with chronic unpredictable mild stress stimuli to replicate the depression rat *** rats were subjected to the open-field and sucrose preference experiments for behavioral observation,and q-PCR was used to detect the mRNA of specific markers of hippocampal astrocytes,glial fibrillary acidic protein,and S100 calcium-binding proteinβ(S100β)in each *** was used to observe the protein expression of glial fibrillary acidic protein and S100βin thehippocampus of rats of each ***:The behavioral results showed that,compared with the control group,the rats in the model group showed a decrease in the score of the open-field experiment and in the rate of sucrose preference(P0.05).The q-PCR results showed that the mRNA and protein expression levels of GFAP and S100βwere downregulated in the model group compared to that of the control group(P<0.05).Compared with the model group,the mRNA expression levels of glial fibrillary acidic proteinand S100βwere upregulated in the traditional Chinese medicine group as well as in the Western medicine group(P<0.05).No significant difference between the Chinese and Western medicine groups was ***:The mechanism of the

关键词： modified wen-dan decoction hippocampal astrocyte Depression Chinese medicine

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