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Study on the accuracy of glomerular filtration rate formulas by double plasma method as "gold standard"

Journal of Hainan Medical University 2019年第19期25卷 42-47页

作者： Tan Ru-Yu Wu Wei-Hua Li Ying Liu Qi Ou San-Tao Department of Nephrology Affiliated Hospital of Southwest Medical University Luzhou Sichuan 646000 China

Objective: To evaluate the accuracy of glomerular filtration rate formula by comparising the CKD-EPI 2009 formula and the modified modified mdrd formula with the 99mTc-DTPA double-phase plasma method as "gold standard" respectively. Methods: Totally 166 patients diognosed as chronic kidney disease (CKD) were enrolled. The 99mTc-DTPA double-plasma method (rGFR) was used as the "gold standard". The CKD-EPI 2009 formula and the modified mdrd formula were used to calculate eGFR. Statistical software was used to analyze the correlation between the calculated values of the two formulas and the gold standard value and the bias. Then we evaluated the accuracy of the two GFR formulas. Results: Among the CKD stage 1 patients, the bias of the CKD-EPI 2009 formula was smaller than that of the modified mdrd formula (13.9911.45;20.1815.90);both formulas were weakly correlated with the gold standard (correlation coefficients were 0.216, 0.229, Pformula less than 15%, 30%, and 50% of the gold standard value is smaller. Among the CKD stage 2 patients, the bias of the CKD-EPI 2009 formula was smaller than that of the modified mdrd formula (12.748.45;15.6811.01);both formulas were moderately correlated with the gold standard (correlation coefficients were 0.568, 0.581, Pformula less than 15%, 30%, and 50% of the gold standard value is smaller. Among the CKD stage 3 patients, the bias of the CKD-EPI 2009 formula was smaller than that of the modified mdrd formula (12.6410.27;12.8810.97), and both formulas were strongly correlated with the gold standard (correlation coefficients were 0.664, 0.670, Pmodified mdrd formula less than 15%, 30%, and 50% of the gold standard value is smaller. Among the CKD stage 4 to 5 patients, the bias of the CKD-EPI 2009 formula was small

关键词： CKD-EPI 2009 formula modified mdrd formula 99mTc-DTPA double-plasma method glomerular filtration rate

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