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The application of open disk-like structures as model membrane and drug carriers

Asian Journal of Pharmaceutical Sciences 2013年第3期8卷 143-150页

作者： Wenping Zhang Jin Sun Zhonggui He Department of Pharmacy General Hospital of Ningxia Medical UniversityYinchuanChina School of Pharmacy Shenyang Pharmaceutical UniversityShenyangChina

The objective of this review is to outline the application of bicelles(or called bilayer micelles)and bilayer nanodisks in pharmaceutics,pharmaceutical analysis and *** application of open disk-like structures as model membrane and drug carrier has been *** exploration of many reports in different fields suggested that these open disk-like structures have great potential in studying interactions between drug-membrane and structure/function studies of membrane-bound ***,they could be applied as promising carriers for in vivo delivery of drugs,protein and peptide.

关键词： Bicelles Bilayer nanodisks model membrane Drug carriers

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Influence of short chain ceramides and lipophilic penetration enhancers on the nano-structure of stratum corneum model membranes studied using neutron diffraction

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Frontiers of Chemical Science and Engineering 2013年第1期7卷 29-36页

作者： Annett SCHROETER Tanja ENGELBRECHT Reinhard H. H. NEUBERT Institute of Pharmacy Martin Luther University Halle-Wittenberg D-06120 Halle/Saale Germany

Oriented stratum corneum model lipid membranes were used to study the influence of the short chain ceramides （CER）[NP] and [AP] as well as the impact of the lipophilic penetration enhancer molecules oleic acid （OA） and isopropyl myristate （IPM） on the lipid nanostrueture. The influence of the enhancer molecules were studied using specifically deuterated OA and IPM and neutron diffraction. 2H NMR spectroscopy was used to study the impact of the ceramides＇ degree of order within the stratum corneum model lipid membranes. It was found that CER[NP] forms two very stable phases with high resistance against temperature increase. Phase B showed unusual hydration behavior as no water uptake of this phase was observed. The 2H NMR spectroscopic measurements showed that CER[NP] based ternary model system had a higher state of lamellar order in comparison to CER[AP] based lipid matrix. The studies confirmed that the short chain ceramides, particularly CER[NP], have a very high impact on the integrity of the Stratum comeum lipid bilayers. The penetration enhancer OA has not influenced the repeat distance of the model membrane based on CER[AP], and was not able to induce a phase separation in the investigated lipid matrix. However, a disorder and a fluidisation of the model membranes were observed when OA was incorporated. IPM showed the same effect but two phases （assigned as phase A and B） appeared, when IPM was used as penetration enhancer and incorporated into the model membrane. Furthermore, two arrangements of IPM were identified in phase A using deuterated IPM. A model of the nanostructure of the Stratum corneum lipid membranes is presented.

关键词： nano-structure of the stratum corneum cer-amide penetration enhancer model membrane neutron diffraction 2H NMR spectroscopy

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