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11th International Vascular Neuroeffector Mechanisms and Cardiovascular Pharmacology and Medicine Symposia, Shanghai-Suzhou 2006

作者： MA Chotani S Mitra AH Eid NA Flavahan Heart and Lung Research Institute Ohio State University Columbus OH USA Heart and Lung Research Institute Ohio State University Columbus OH USA Heart and Lung Research Institute Ohio State University Columbus OH USA Heart and Lung Research Institute Ohio State University Columbus OH USA

Heptahelical α-adrenoceptors (α-ARs) are members of the G-protein-coupled receptor (GPCR) superfamily and mediate vascular responses to norepinephrine and epinephrine. Efficient activation and signaling of α-ARs requires that the receptors be correctly localized within the plasma membrane. However, for certain subtypes of α1-ARs and α2-ARs, the receptors are sequestered within intracellular compartments. The directed mobilization of these receptor

关键词： mobilizing VSMCs adrenoceptors:a novel mechanism for regulating vascular neuroeffector function

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Potential for a pluripotent adult stem cell treatment for acute radiation sickness

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World Journal of Experimental Medicine 2012年第3期2卷 37-44页

作者： Denis O Rodgerson Bruce E Reidenberg Alan G Harris Andrew L Pecora Ne-oS tem Inc. New York NY 10170 United States Department of Pharmacology Weill Medical College of Cornell University The Cancer Center Hackensack University Medical Center

Accidental radiation exposure and the threat of deliberate radiation exposure have been in the news and are a public health concern. Experience with acute radiation sickness has been gathered from atomic blast survivors of Hiroshima and Nagasaki and from civilian nuclear accidents as well as experience gained during the development of radiation therapy for cancer. This paper reviews the medical treatment reports relevant to acute radiation sickness among the survivors of atomic weapons at Hiroshima and Nagasaki, among the victims of Chernobyl, and the two cases described so far from the Fukushima Dai-Ichi disaster. The data supporting the use of hematopoietic stem cell transplantation and the new efforts to expand stem cell populations ex vivo for infusion to treat bone marrow failure are reviewed. Hematopoietic stem cells derived from bone marrow or blood have a broad ability to repair and replace radiation induced damaged blood and immune cell production and may promote blood vessel formation and tissue repair. Additionally, a constituent of bone marrow-derived, adult pluripotent stem cells, very small embryonic like stem cells, are highly resistant to ioniz-ing radiation and appear capable of regenerating radiation damaged tissue including skin, gut and lung.

关键词： Nuclear accident Acute radiation syndrome Radiological casualties Stem cell transplantation Cellular therapy Emergency response Ionizing radiation injury Hematopoietic rescue Pluripotent stem cells Induced pluripotent stem cells Mesenchymal stem cells Very small embryonic-like stem cells mobilizing agents

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