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pH-Controlled DNA Molecular Switch Using minidumbbell

医用生物力学 2019年第A1期34卷 176-176页

作者： Pei Guo Sik Lok Lam School of Biology and Biological Engineering South China University of TechnologyGuangzhou510006China Department of Chemistry The Chinese University of Hong KongShatinNew TerritoriesHong Kong

DNA is an attractive biomaterial for constructing nanomachines and nanomaterials owing to their self-recognition and self-assembly *** addition to the well-known double helical structures,DNA molecules can also form a variety of unusual structures like hairpins,triplexes and *** unusual DNAs sometimes have advantages over double helical DNAs in constructing nanomachines such as enhanced thermodynamic stability and higher sensitivity to external stimuli,which made them as promising motifs in recenttwo *** of how complicated DNA-based nanomachines are,the fundamental concept in these nanomachines is based on a proper design and usage of DNA molecular *** the reported DNA molecular switches,pH-controlled systems show great potentials in drug delivery and cellular pH *** to now,most of the reported pH-controlled molecular switches used i-motif or triplex ***,owing to the relatively long sequence requirement for the formation of i-motif and triplex DNAs,an invading DNA strand needs to be added to activate the molecular switch,and thus DNA wastes will be generated into the system and a full structural conversion will usually take a relatively long time of minutes to *** overcome the disadvantages of DNA waste generation and slow kinetics,molecular switches using smaller-size,thermodynamically stable and pH-sensible unusual DNA structures will have the advantages of easier manipulation and faster ***,we discovered a new type of unusual DNA structure called the minidumbbell(MDB)which is formed by a single-strand 8-nucleotide *** MDB is composed of two type II tetraloops in which the first and fourth loop residues form loop-closing base pairs,the second loop residues fold into the minor groove to form base-base stacking or mispairing interactions,and the third loop residues stack on their nearby loop-closing base *** particular,the MDB formed by a sequence containing two CCTG re

关键词： MDB pH-Controlled DNA Molecular Switch Using minidumbbell DNA

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