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Epidemiology of coal miners’pneumoconiosis and its social determinants:An ecological study from 1949 to 2021 in China

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Chinese Medical Journal Pulmonary and Critical Care Medicine 2023年第1期1卷 46-55页

作者： Huanqiang Wang Qiao Ye Yun Chen Tao Li Department of Occupational Respiratory Diseases National Institute of Occupational Health and Poison ControlChinese Center for Disease Control and PreventionBeijing 100050China Department of Occupational Medicine and Toxicology Clinical Center for Interstitial Lung DiseasesBeijing Institute of Respiratory MedicineBeijing Chao-Yang Hospital Capital Medical UniversityBeijing 100020China

Background:Pneumoconiosis is the most widely distributed occupational disease *** is currently the largest coal producer and consumer and the country with the most coal miners and cases of coal workers’pneumoconiosis(CWP).Despite more than 70 years of effort,the problem of CWP and silicosis remains *** is a lack of analysis of direct data on coal miners’pneumoconiosis from all over the *** study aimed to describe the epidemiology of coal miners’pneumoconiosis and reveal some important clues regarding its social ***:The annual incidence rate,20-year prevalence rate,and incidence rate of coal miners’pneumoconiosis per million tons in China from 1949 to 2021 were calculated by using the data of annual number of coal miners’pneumoconiosis diagnosed and reported from the coal mining and dressing industry,the number of coal miners,and the raw coal production,and the relationship between the incident cases of coal miners’pneumoconiosis and the death toll from coal mine safety accidents was analyzed using Pearson correlation analysis,with the aim of exploring the relationship between the incident cases of coal miners’pneumoconiosis and its social determinants with an ecological ***:From 1949 to 2021,there have been more than 462,000 patients with coal miners’pneumoconio-sis in China,showing double U-shaped distributions with an increasing trend,accounting for about 50.5%(462,000/915,000)of all diagnosed pneumoconiosis in China,while the incidencet rate of coal miners’pneu-moconiosis presents a large W shaped distribution with three peaks over a time span of more than 50 *** 1949 to 1986,there was a strong correlation between the incident cases of coal miners’pneumoconiosis and raw coal production,the number of coal miners,and the number of deaths from coal mine accidents(r=0.849,P<0.001;r=0.817,P<0.001;r=0.697,P<0.001,respectively),but there was no such correlation found from 1987 to *** was estimated that

关键词： miners Pneumoconiosis Social determinants of health(SDH) Risk factors

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Pathogenesis sequences in Gejiu miners with lung cancer： an introduction

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Frontiers of Medicine 2015年第3期9卷 344-349页

作者： Li Bian Yonghua Ruan Liju Ma Hairong Hua Li Zhou Xiaoyu Tuo Zheyan Zhou Ting Li Shiyue Liu Kewei Jin Department of Pathology The First Afflfiated Hospital of Kunming Medical University Kunming 650032 China Department of Pathology Kunming Medical University Kunming 650031 China Department of Clinical Medicine Research The First Affiliated Hospital of Kunming Medical University Kunming 650032 China Department of Oncology The Seventh People's Hospital of Shanghai Shanghai 200137 China Department of Pathology The Third People's Hospital of Yunnan Province Kunming 650011 China

Tin miners in Gejiu, Yunnan Province, China are at high risk of developing lung cancer with significant occupational characteristics. Tissue samples from these miners presented pathological characteristics, such as fibroplasia in carcinomas, peri-cancerous tissue in lung cancers, and hyperplasia and dysplasia of epithelial cells in peri-cancerous tissue. Carcinomas induced by Yunnan tin mine dust in the animal experiment underwent inflammation, fibroplasia, hyperplasia, dysplasia, and carcinogenesis of epithelial ceils. A correlated and synergistic relationship was observed between bronchial epithelial cell transformation and fibroblast activation in vitro induced by mine dust. Fibroblast hyperplasia and activation are important factors that promote the transformation and carcinogenesis of epithelial cells. Our findings suggested that pulmonary fibrosis may increase the risk and promote the occurrence of lung cancer, which can lead to lun~ fiber hyperplasia.

关键词： Yunnan tin mine miners lung cancer

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The Simulation Optimization of miners’ Unsafe Behavior Control Method

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Journal of Systems Science and Information 2019年第2期10卷 148-160页

作者： Jiangshi ZHANG Hongyu HAO Xue LI Wenyue ZHANG College of Resources and Safety Engineering China University of Mining and Technology (Beijing)

Making optimal safety investment decisions are important for improving worker’s safety level and reducing accident frequency. To study the complex relationship between safety investment and miners’ behavior-based safety, we proposed the index system of the influential factors on miners’ unsafe behaviors and utilized system dynamics(SD) method to construct the analysis model. Based on the empirical research on a mining company in Hunan, miners’ behavior-based safety level under different investment conditions were simulated, then 12 kinds of schemes’ simulation were obtained. Finally,the optimal scheme was achieved. The scheme is: Safety cost per ton of coal is 3.8 dollars, investment proportion is: Organizational management(0.44), safety climate(0.16), working environment(0.08),technological equipment(0.32). This scheme reached the target value of 90 in the 28th month, which was 9 months shorter than that of the original one. The optimized results show that increasing the behavior-based safety investment and adjusting the proportion appropriately, can improve miners’ behavior-based safety level effectively.

关键词： miners system dynamics safety investment

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The Cytokinesis-Block Micronucleus Assay on Peripheral Blood Lymphocytes as a Prospective Biological Test-System to Estimate the Influence of Radon on the Human Organism: Recent Progress and Future Prospects

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Open Journal of Genetics 2014年第1期4卷 1-7页

作者： Maxim Yu. Sinitsky Department of Genetics Kemerovo State University Kemerovo Russia

This paper discusses the problem of assessing the negative after-effects of low doses of ionising radiation exposure in humans. Radon and its decay daughter products are the most widespread source of such irradiation. miners (in both uranium and non-uranium mines) as well as laypeople in domestic life may be exposed to radon, making the problem of assessing the cytogenetic effects of exposure extremely crucial. One of the more promising test systems to assess the effect of radon is the cytokinesis-block micronucleus assay (CBMN) on peripheral blood lymphocytes, which has a number of advantages over other cytogenetic techniques. Recent progress and future prospects of this cytogenetic method are discussed here.

关键词： Micronucleus Assay Micronuclei CBMN DNA Damage Radon Uranium Coal miners

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