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Comprehensive bioinformatic analysis of mind bomb 1 gene in stomach adenocarcinoma

World Journal of Gastrointestinal Oncology 2023年第7期15卷 1295-1310页

作者： Di Wang Qi-Hong Wang Ting Luo Wen Jia Jing Wang Department of Digestive Endoscopy The General Hospital of Northern Theater CommandShenyang 110840Liaoning ProvinceChina Postgraduate College China Medical UniversityShenyang 110840Liaoning ProvinceChina

BACKGROUND The carcinogenesis of stomach adenocarcinoma(STAD)involves many different molecules and multiple pathways,including the NOTCH signaling *** a key factor that functions as a critical link in the NOTCH pathway,mind bomb 1(MIB1)is upregulated in various tumors and has been reported to promote cell metastasis and ***,studies on the role of MIB1 in STAD are ***,we evaluated the prognostic value of MIB1 in STAD and its association with immune infiltration and copy number *** To elucidate the relationship between MIB1 gene and gastric cancer(GC)and provide a new idea for the treatment of *** We identified mutations in the MIB1 gene by searching the cBioPortal database and then analyzed their relationship with the overall survival rate and diseasefree survival rate using the Kaplan-Meier *** Cancer Genome Atlas(TCGA)database provided transcript levels for MIB1 in STADs and normal *** a method of distinguishing the STAD tissues from adjacent normal tissues,a receiver operating characteristic(ROC)curve was ***-Meier plotter was used to determine the effect of MIB1 expression on *** on the LinkedOmics database,we were able to identify the coexpressed genes of the MIB1 gene,the top 50 positively correlated genes,and the top 50 negatively correlated *** was used to construct protein-protein interaction networks related to the MIB1 *** analysis of functional enrichment was carried out using the R package“Cluster Profiler”.The relationships between mRNA expression of MIB1 and immune infiltrates were assessed by Tumor IMmune Estimation Resource(TIMER)and the“GSVA package”in *** According to the cBioPortal database,the MIB1 mutation rate in 287 patients in the TCGA dataset was approximately 6%.Kaplan-Meier survival analysis showed that patients with STAD in the mutated group had a worse prognosis than those in the unmutated group(P=0.0156).There was a significant upregul

关键词： Stomach adenocarcinoma mind bomb 1 Mutation Prognosis Biomarker Immune infiltration

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