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第十一届全国化学生物学学术会议

作者： Jiang Shikun Wu Yanling Cao Song Zhao Xiaoyin Fu Wei Xue Lingxiao Wei Chuanhe Zhang Wen Lab of Chemical Biology and Molecular Drug Design College of Pharmaceutical ScienceZhejiang University of Technology Institute of Drug Development & Chemical Biology Zhejiang University of Technology Lab of Molecular Immunology Virus Inspection DepartmentZhejiang Provincial Center for Disease Control and Prevention College of Pharmacy East China University of Science and Technology

Benzoxazinone derivatives are small molecules with antiplatelet aggregation and antiviral and anticancer properties. In this study, by morphological analysis, RTCA, wound healing assay, RT-PCR, EMSA, and CD techniques, we explored the effects of four synthesized benzoxazinone derivatives as screening drugs on cancer cells overexpressing c-Myc（H7402, HeLa, SK-RC-42, SGC7901, and A549） and preliminarily investigated their mechanisms of interaction. In conclusion, the studied compounds could inhibit growth and migration of the examined cancer cells dose-dependently. This was positively correlated with the suppression of c-Myc gene overexpression, which could be mediated greatly by the interaction of compounds with G-quadruplexes formed in the c-Myc gene promoter sequence. We conclude that three of the compounds deserve to be further explored as leading compounds of anticancer drugs, in particular for non–small-cell lung cancer.

关键词： Benzoxazinones cancer cells antiproliferation migration inhibition c-Myc gene G-quadruplex

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Disturbing cytoskeleton by engineered nanomaterials for enhanced cancer therapeutics

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Bioactive Materials 2023年第11期29卷 50-71页

作者： Xueli Xu Shanbin Xu Jipeng Wan Diqing Wang Xinlong Pang Yuan Gao Nengyi Ni Dawei Chen Xiao Sun School of Science Shandong Jianzhu UniversityJinan250101China Shandong Cancer Hospital and Institute Shandong First Medical University and Shandong Academy of Medical SciencesJinan250117China Department of Gynecology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan250021China School of Chemistry and Pharmaceutical Engineering Medical Science and Technology Innovation CenterShandong First Medical University&Shandong Academy of Medical SciencesJinan250000China Department of Chemical and Biomolecular Engineering National University of Singapore117585Singapore

Cytoskeleton plays a significant role in the shape change,migration,movement,adhesion,cytokinesis,and phagocytosis of tumor *** clinical practice,some anti-cancer drugs achieve cytoskeletal therapeutic effects by acting on different cytoskeletal protein ***,in the absence of cell-specific targeting,unnecessary cytoskeletal recombination in organisms would be disastrous,which would also bring about severe side effects during anticancer *** have been proven to be superior to some small molecule drugs in cancer treatment due to better stability and targeting,and lower side ***,this review summarized the recent developments of various nanomaterials disturbing cytoskeleton for enhanced cancer therapeutics,including carbon,noble metals,metal oxides,black phosphorus,calcium,silicon,polymers,peptides,and metal-organic frameworks,etc.A comprehensive analysis of the characteristics of cytoskeleton therapy as well as the future prospects and challenges towards clinical application were also *** aim to drive on this emerging topic through refreshing perspectives based on our own work and what we have also learnt from *** review will help researchers quickly understand relevant cytoskeletal therapeutic information to further advance the development of cancer nanomedicine.

关键词： Nanomedicine Disturbing cytoskeleton migration inhibition Tumor therapy

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