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Cardiovascular health awareness,risk perception,behavioural intention and INTERHEART risk stratification among middle-aged adults in Malaysia

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Asian Pacific Journal of Tropical Medicine 2024年第2期17卷 61-70页

作者： Siew-Keah Lee Ang-Lim Chua Clement Heng Yew Fong Ban Hao Brian Cong Wen Ling Ng Jing Feng Kong Yik-Ling Chew Kai Bin Liew Yang Shao M.Kandiah Faculty of Medicine and Health Sciences Universiti Tunku Abdul RahmanMalaysia Faculty of Medicine Universiti Teknologi MARAMalaysia Faculty of Pharmaceutical Sciences UCSI UniversityMalaysia Faculty of Pharmacy University of CyberjayaMalaysia The First Affiliated Hospital of Hainan Medical University China

Objective:To investigate the interrelationship between cardiovascular health awareness,risk perception,behavioural intention,and INTERHEART risk stratification in a middle-aged adult population in ***:A cross-sectional survey with convenience sampling was conducted during November 2022 and January *** completed validated questionnaires assessing cardiovascular health awareness,risk perception of cardiovascular diseases,behavioural intention towards adopting healthy habits,and INTERHEART risk stratification score(IHRS)based on established risk factors.A total of 602 respondents were included in the final *** were analysed with independent t-test/one-way ANOVA or Mann-Whitney/Kruskal-Wallis to test the differences,Pearson correlation or linear regression test to analyze the association of independent and dependent ***:There was a significant positive correlation between medical knowledge related to cardiovascular disease(CVD)and knowledge related to CVD risk prevention,risk perception,behavioural intention and IHRS(P<0.05,Pearson correlation).Notably,individuals with higher IHRS tended to have lower knowledge related to CVD and CVD risk prevention,risk perception,and behavioural ***,laborers,active/former smokers,individuals with lower household income and educational levels,those involved in occupations not related to the healthcare sector,and those who did not receive the CVD health brochure or are unaware of health self-assessment tools are likely to have lower levels of knowledge,risk perception,and poorer behavioural intention regarding cardiovascular health(P<0.05,one-way ANOVA).While educational level,smoking status,awareness about CVD poster,self-assessment tools were repeatedly significantly associated with knowledge related to CVD and CVD risk prevention,risk perception,behavioral intention and/or IHRS(P<0.05,linear regression).Conclusions:These findings underscore the importance of promoting car

关键词： Cardiovascular risk Knowledge Risk perception Behavioural intention INTERHEART middle-aged Lifestyle Physical activity Psychosocial stress

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High Sensitivity C-Reactive Protein Associated with Different Health Predictors in middle-aged and oldest old Chinese

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Biomedical and Environmental Sciences 2012年第3期25卷 257-266页

作者： ZHAI Yi SHI Xiao Ming FITZGERALD Simon Michael QIAN Han Zhu KRAUS Virginia B SERENY Melanie HU Perry YIN Zhao Xue XU Jian Wei ZENG Yi Chinese Center for Disease Control and Prevention Beijing 102206 China SUNY Downstate College of Medicine NY 11218 USA Division of Epidemiology Vanderbilt University School of Medicine TN 37203-1738 USA Department of Sociology Duke University Durham NC 27708 USA Department ofSociology Duke University Durham NC 27708 USA Ronald Reagan UCLA Medical Center Los Angeles CA90095USA Center for the Study of Aging and Human Development and Geriatric Division of Medical SchoolDuke University Box 3003 Room 1506 BUSSE Building Durham NC27710 USA China Center for EconomicResearch National School of Development at Peking University Beij'ing 100087 China

Objective To describe the distribution of plasma high sensitivity C-reactive protein （hsCRP） and explore the relationship between hsCRP and metabolic risk factors among residents living in longevity areas of China. Methods 268 individuals aged between 40 and 59 years and 506 individuals aged over 90 years were selected from 5 longevity areas of China to participate in a cross section longitudinal cohort study. The participants were interviewed with general health related questionnaire to collect their demographic, behavioral and lifestyle data, as well as their chronic conditions, and meanwhile their physical and biomedical parameters including waist circumference （WC）, blood pressure （BP）, hsCRP, plasma lipids, and fasting blood glucose （FBG） were measured. Results The median of hsCRP was 0.99 mg/L in the middle-aged group and 2.76 mg/L in the oldest old group. No significant gender difference was observed between the above two groups. Among the oldest old individuals, 36.56% had an hsCRP level 〉3.0 mg/L. The prevalence of high hsCRP was 26.79% in the middle-aged group. The results of stepwise multiple linear regression analyses showed that HDL-C was independently associated with In （hsCRP） concentration in the middle-aged group, whereas In （TG）, HDL-C and FBG were correlated after adjustment for gender, study site, smoking, drinking, education and BMI in the oldest old group. Conclusion HDL-C is a stronger predictor of elevated hsCRP than other metabolic factors in the middle-aged population. For the oldest old persons, high TG, low HDL-C, and FBG predict elevated plasma hsCRP.

关键词： High-sensitivity C-reactive protein Blood lipids Fasting blood glucose middle-aged Oldestold individuals Longevity China

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Altered Allogeneic Immune Responses in middle-aged Mice

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Cellular & Molecular Immunology 2004年第6期1卷 440-446页

作者： Alan N.Langnas Department of Surgery University of Nebraska Medical CenterThe Lied Transplant CenterUNMCOmahaNEUSA.

It is well known that leukocyte composition,T cell phenotypes and immune function change in aged mice and ***,limited and conflicting results on the age-related immune changes in middle-aged mice were *** of the characteristics of allogeneic immune responses in aging mice may offer important information for transplantation *** major age-related changes in the immune cell phenotypes and function of 12 months old mice include:1)the significantly decreased CD4^+ cell population in the peripheral blood,the major peripheral CD4^+ cells is CD45RB^(low)CD62L^(low)memory phenotype;2)the in vitro responses to alloantigens and Con A of splenocytes markedly reduced;3)the in vivo secondary humoral immune responses to alloantigens significantly declined;4)the age-related alteration in the thymus mainly occurred in CD4/CD8 double positive(DP)stage;and 5)increased CD80^+ and MHC class II^+ cell population in ***,the major age-related immune changes in 12 months old mice occurred in CD4^+ T cells in the periphery and DP stage in the thymus,which may subsequently lead to the decreased allogeneic immune responses and the different sensitivity to immunosuppressive drugs and *** studies on the characteristics of allogeneic immunity in aging individuals may help to determine the appropriated treatment for transplant aging *** & Molecular Immunology.2004;1(6):440-446.

关键词： allogene middle-aged transplantation

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Case of clear-cell hepatocellular carcinoma that developed in the normal liver of a middle-aged woman

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World Journal of Gastroenterology 2008年第1期14卷 129-131页

作者： Atsushi Takahashi Hironobu Saito Yukiko Kanno Kazumichi Abe Junko Yokokawa Atsushi Irisawa Akira Kenjo Takuro Saito Mitsukazu Gotoh Hiromasa Ohira Department of Internal Medicine Ⅱ Fukushima Medical University School of Medicine 1 Hikarigaoka Fukushima 960-1295 Japan Department of Surgery Ⅰ Fukushima Medical University School of Medicine 1 Hikarigaoka Fukushima 960-1295 Japan

A 36-year-old woman was admitted to our department for close examination of a liver tumor that was found during a medical checkup. Abdominal US, CT and MRI showed a tumor in segment 7 (S7) of the liver. Although imaging suggested hepatocellular carcinoma, laboratory tests showed no abnormality in liver function, hepatitis virus markers were negative, and tumor markers including protein induced by vitamin K absence or antagonist Ⅱ (PIVKA-Ⅱ), α-fetoprotein (AFP), carbohydrate antigen 19-9 (CA19-9), and carcinoembryonic antigen (CEA) were all within normal ranges. Upon aspiration biopsy of the liver, the histopathological diagnosis was moderately differentiated hepatocellular carcinoma. Therefore, right hepatectomy was performed. Although a part of the tumor was necrotic, about 60% of the viable part showed a clear-cell variant. Consequently, it was diagnosed as clear-cell hepatocellular carcinoma. It was noted that the background liver tissue was normal. This case is worthy of reporting because development of clear-cell hepatocellular carcinoma in the normal liver of a middle-aged woman is rarely seen.

关键词： Clear-cell hepatocellular carcinoma Liver middle-aged

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Factors associated with financial support in old age for young and middle-aged rural residents in China

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Chinese Journal of Population,Resources and Environment 2015年第2期13卷 169-176页

作者： Suyan Shen Fang Li John Kipkorir Tanui College of Public Administration Nanjing Agricultural University Department of Agricultural Economics Moi University

This study examined the factors associated with financial support in old age from three primary mechanisms-personal savings,family support,and social insurance-to explore the implications for the future development of China's rural social welfare ***-sectional surveys of 1392 young and middle-aged rural residents were conducted in July and *** results showed that while social insurance was increasingly acceptable,personal savings and family support still had fundamental *** the three mechanisms,the rural old-age welfare system presented nontraditional ***'s new rural endowment insurance is discussed as a means to address the need for financial support among the rural aging population.

关键词： old-age financial support young and middle-aged rural residents personal savings family support social insurance

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The Quality of Life of Chinese middle-aged Male Patients with Gastric Carcinoma After Total Gastrectomy and Nursing Intervention

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Clinical oncology and cancer researeh 2010年第2期7卷 151-156页

作者： Yan WANG Hui-ying WANG Guo-hong YIN Hui-zi TIAN Dan WANG Department of Gastroenterological Cancer Tianjin Medical University Cancer Institute and Hospital Tianjin 300060 China.

OBJECTIVE The purpose of this study was to evaluate the quality of life （QOL） in Chinese middle-aged male patients with gastric carcinoma after total gastrectomy, to investigate the factors affecting their QOL, and to Study the effectiveness of nursing *** Structured questionnaire （EORTC QLQ-C30） was used among 162 middle-aged male patients after total gastrectomy （the patients finished the whole process of chemotherapy, and returned home, and society） for data collection and reevaluate the patients＇ aualitv of life with 2 months nursing *** The patient＇s quality of life was related to their education level, economic condition, family support, and pathological staging. This study showed that patients got higher scores in Functional scales （except for CF）, and lower scores in Symptom scales and single items （except for FI） after receiving intervention than before it was received *** The study revealed that the QOL in middleaged male patients after total gastrectomy was worse when there was inadequate attention. After implementing pertinent nursing intervention implementing, patients＇ mental attitude and negative behavior were improved, and their QOL was enhanced after returning home and into society.

关键词： middle-aged patients gastrectomy quality oflife nursing.

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Psychosocial Factors Affecting the Use of Mammography Testing for Breast Cancer Susceptibility: An Eight-Month Follow-Up Study in a middle-aged Japanese Woman Sample

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Open Journal of Medical Psychology 2013年第4期2卷 158-165页

作者： Keiichiro Adachi Toshinori Kitamura Tokumi Ueno Department of Psychology Faculty of Human Sciences Kobe Shoin Women’s University Hyogo Japan Department of Social and Clinical Psychology Faculty of Medicine Oita University Oita Japan Kitamura Institute of Mental Health Tokyo Japan

We examined the psychosocial factors affecting middle-aged Japanese women’s intentions to undergo mammography, as well as their actual usage of mammography by applying the Parallel Processing Model (PPM) of self regulation longitudinally. A total of 1030 middle-aged women living in all parts of Japan participated in this study through internet research from September 2010 to May 2011. The participants were evaluated on the basis of a battery of questionnaires mainly including demographics, perceived breast cancer risk, worry about breast cancer, mammography testing beliefs, intentions to use mammography, seeking information about mammography, and actual usage of mammography thrice over an eight-month period. The main results were as follows: 1) Perceived risk and cancer worry affected the intention of undergoing mammography, and this effect was mediated by beliefs about mammography testing. 2) Intention to use mammography and past mammography usage predicted future usage of mammography, with past mammography usage being the strongest predictor. 3) Information seeking about mammography was the strongest predictor of using mammography during the eight-month follow-up period of middle-aged women who had not undergone any mammography testing. PPM was a useful model to explain the mechanism behind middle-aged Japanese women’s intentions to use mammography, as well as their actual usage of mammography. In addition, past mammography experience was the strongest predictor of regular mammography usage and information seeking was a critical factor for the first-usage of mammography.

关键词： Mammography Usage Psychosocial Factors middle-aged Japanese Woman Parallel Processing Model of Self-Regulation

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Excessive 5-year weight gain predicts metabolic syndrome development in healthy middle-aged adults

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World Journal of Diabetes 2011年第1期2卷 8-15页

作者： Jong-Dar Chen Pau-Chung Chen Department of Family Medicine Shin Kong Wu Ho-Su Memorial Hospital Institute of Occupational Medicine and Industrial Hygiene College of Public HealthNational Taiwan University

AIM:To quantitatively examine the impacts of an easyto-measure parameter-weight gain-on metabolic syndrome development among middle-aged adults. METHODS:We conducted a five-year interval observational study.A total of 1384 middle-aged adults not meeting metabolic syndrome(MetS)criteria at the initial screening were included in our *** data such as MetS-components and lifestyle factors were collected in *** weight and MetS-components were measured in both 2002 and *** were classified according to proximal quartiles of weight gain(WG)in percentages(%WG≤1%,1%10%, defined as:control,mild-WG,moderate-WG and severe-WG groups,respectively)at the end of the follow-up. Multivariate models were used to assess the association between MetS outcome and excessive WG in the total population,as well as in both genders. RESULTS:In total,175(12.6%)participants fulfilled MetS criteria within five *** comparison to the control group,mild-WG adults had an insignificant risk for MetS development while adults having moderate-WG had a 3.0-fold increased risk for progression to MetS [95%confidence interval(CI),1.8-5.1],and this risk was increased 5.4-fold(95%CI,3.0-9.7)in subjects having *** females having moderate-and severe-WG,the risk for developing MetS was 3.6(95% CI,1.03-12.4)and 5.5(95%CI,1.4-21.4),respectively. For males having moderate-and severe-WG,the odds ratio for MetS outcome was respectively 3.0(95%CI, 1.6-5.5)and 5.2(95%CI,2.6-10.2). CONCLUSION:For early-middle-aged healthy adults with a five-year weight gain over 5%,the severity of weight gain is related to the risk for developing metabolic syndrome.

关键词： Excess weight gain Metabolic syndrome middle-aged adults Follow-up Worker population

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Physiotherapist-led home-based physical activity program versus community group exercise for middle-aged adults: Quasi-experimental comparison

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Open Journal of Preventive Medicine 2013年第2期3卷 229-237页

作者： Nicole Freene Gordon Waddington Wendy Chesworth Rachel Davey Tom Cochrane Centre for Research & Action in Public Health Faculty of Health University of Canberra Bruce Australia Faculty of Health University of Canberra Bruce Australia Physiotherapy Faculty of Health University of Canberra Bruce Australia

Objectives: Program method, program deliverer and participant preference may be important factors in increasing physical activity adherence and program effectiveness. To investigate this, we compared two physical activity interventions in middle-aged adults. Methods: Using a pragmatic quasi-experimental design, sedentary community dwelling 50 - 65 year olds (n = 2105) were recruited to a non-randomized 6-month community group exercise program (n = 93) or a physiotherapist-led home-based physical activity program (n = 65). The primary outcome was physical activity adherence derived from exercise diaries. Secondary outcomes included the Active Australia Survey, aerobic capacity (step- test), quality of life (SF-12v2), blood pressure, waist circumference, waist-to-hip ratio (WHR) and body mass index. Results: Home-based participants were more likely to be younger, working full-time and not in a relationship (p Thirty-three percent of the group participants attended ≥ 70% of group exercise sessions. Ninety percent of home-based participants received ≥ 4 of the planned 6 telephone support calls. Intention-to-treat analysis found adherence to the physical activity sessions prescribed was the same for both interventions (26% ± 28% vs. 28% ± 35%). Both interventions significantly increased the number of participants achieving self-reported “sufficient” physical activity (p ≤ 0.001) and significantly decreased waist circumference (p middle-aged adults. The home-based program, providing equivalent health benefits to the group exercise program, may be particularly suitable for those not interested in or unable to attend a group exercise program. Clinical Trial Registration number Australian New Zealand Clinical Trials Regist

关键词： Physiotherapy Home-Based Physical Activity Adoption Adherence middle-aged

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Correlation of blood uric acid level with the degree of anxiety as well as the neurotransmitter and cytokine secretion in young and middle-aged patients with anxiety disorder

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Journal of Hainan Medical University 2019年第2期25卷 62-65页

作者： Xiao-Bei Liu Xiao-Jun Hou Neurology Department Shanghai Changhai HospitalShanghai200433

Objective:To study the correlation of blood uric acid level with the degree of anxiety as well as the neurotransmitter and cytokine secretion in young and middle-aged patients with anxiety ***: The young and middle-aged patients diagnosed with generalized anxiety disorder in our hospital between March 2015 and February 2018 were selected as the anxiety group, and the healthy subjects receiving physical examination during the same period were selected as the control group. Peripheral blood was collected to determine the contents of uric acid, neurotransmitters and cytokines, and Hamilton Anxiety Scale (HAMA) was adopted to judge the degree of ***: The blood uric acid level of anxiety group was obviously higher than that of control group and the higher the HAMA scores, the more significant the rising of blood uric acid levels;serum 5-hydroxytryptamine (5-HT), norepinephrine (NE), dopamine (DA), interleukin-1α (IL-1α), IL-17 and interferon-γ (IFN-γ) contents of anxiety group were significantly higher than those of control group whereas neuropeptide Y (NPY), IL-4 and transforming growth factor-β (TGF-β) contents were significantly lower than those of control group;blood uric acid level of the anxiety group was positively correlated with 5-HT, NE, DA, IL-1 , IL-17 and IFN-γ contents, and negatively correlated with NPY, IL-4 and TGF-β ***: The rise of blood uric acid level in young and middle-aged patients with anxiety disorder is related to the aggravation of anxiety degree as well as the abnormal secretion of neurotransmitters and cytokines.

关键词： Anxiety disorder in the young and middle-aged Blood uric acid Neurotransmitter Cytokine

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