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MoS_(2)-based nanocomposites for cancer diagnosis and therapy

Bioactive Materials 2021年第11期6卷 4209-4242页

作者： Jianling Wang Lihua Sui Jia Huang Lu Miao Yubing Nie Kuansong Wang Zhichun Yang Qiong Huang Xue Gong Yayun Nan Kelong Ai Xiangya School of Pharmaceutical Sciences Central South UniversityChangsha410078China Hunan Provincial Key Laboratory of Cardiovascular Research Xiangya School of Pharmaceutical SciencesCentral South UniversityChangsha410078China Department of Pathology Xiangya HospitalCentral South UniversityChangshaHunan410078China Department of Pathology School of Basic Medical ScienceCentral South UniversityChangshaHunan410013China Department of Pharmacology Xiangya HospitalCentral South UniversityChangsha410008HunanChina Department of Radiology The Second Hospital of Jilin UniversityChangchun130041China Geriatric Medical Center Ningxia People’s HospitalYinchuanChina

Molybdenum is a trace dietary element necessary for the survival of humans.Some molybdenum-bearing enzymes are involved in key metabolic activities in the human body(such as xanthine oxidase,aldehyde oxidase and sulfite oxidase).Many molybdenum-based compounds have been widely used in biomedical research.Especially,MoS_(2)-nanomaterials have attracted more attention in cancer diagnosis and treatment recently because of their unique physical and chemical properties.MoS_(2)can adsorb various biomolecules and drug molecules via covalent or non-covalent interactions because it is easy to modify and possess a high specific surface area,improving its tumor targeting and colloidal stability,as well as accuracy and sensitivity for detecting specific biomarkers.At the same time,in the near-infrared(NIR)window,MoS_(2)has excellent optical absorption and prominent photothermal conversion efficiency,which can achieve NIR-based phototherapy and NIR-responsive controlled drug-release.Significantly,the modified MoS_(2)-nanocomposite can specifically respond to the tumor microenvironment,leading to drug accumulation in the tumor site increased,reducing its side effects on non-cancerous tissues,and improved therapeutic effect.In this review,we introduced the latest developments of MoS_(2)-nanocomposites in cancer diagnosis and therapy,mainly focusing on biosensors,bioimaging,chemotherapy,phototherapy,Microwave hyperthermia,and combination therapy.Furthermore,we also discuss the current challenges and prospects of MoS_(2)-nanocomposites in cancer treatment.

关键词： MoS_(2) Cancer Biosensor Bioimaging Chemotherapy Phototherapy Microwave hyperthermia Combination therapy

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Fabrication of microwave-sensitized nanospheres of covalent organic framework with apatinib for tumor therapy

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Chinese Chemical Letters 2023年第5期34卷 427-432页

作者： Qijun Du Jian Zou Zhongbing Huang Shimei Li Longfei Tan Xiangling Ren Guangfu Yin Yongfa Zheng Xianwei Meng College of Biomedical Engineering Sichuan UniversityChengdu 610065China Laboratory of Controllable Preparation and Application of Nanomaterials CAS Key Laboratory of CryogenicsTechnical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China Sichuan Kangcheng Biotechnology Co. Ltd.Chengdu 610041China Department of Oncology Renmin Hospital of Wuhan UniversityWuhan 430060China

A new nanocomposite of hollow covalent organic framework(COF)conjugated with the apatinib(AP)and loading microwave-sensitizer(ionic liquid,IL)was prepared by layer by layer(LBL)method and hyaluronic acid(HA)coating,named as COF-AP-IL@HA.AP loading rate in COF hollow-spheres(~30 nm shell thickness)was~40.3%,due to the interactions of hydrogen andπ-πbonds between AP and COF shell,and acidic environment destroyed COF structure,promoting AP release.microwave sensitization of loaded IL in COF hollow-spheres could enhance the microwave heat-effect,and combined AP therapeutic ability,leading to their higher inhibitation on tumor,due to targeting ability of HA and the local release of apatinib.88.9%of inhibition rate of COF-AP-IL@HA under microwave on the in vivo tumor was significantly higher than those without microwave(12.3%)and COF-IL@HA with microwave(37.5%),indicating a synergism of sensitized Microwave hyperthermia and AP therapy on the reduced expression of VEGF via the downregulation pathway of hypoxia inducible factor.These results indicated that COF-AP-IL@HA was potential to the application in the combination therapy of tumor of the sensitized Microwave hyperthermia and apatinib.

关键词： Covalent organic framework Antiangiogenesis Tumor therapy Microwave hyperthermia Hollow spheres

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医用介质部分加载波导辐射器

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微波学报 1987年第3期4卷 50-54页

作者：江汉保明德惠邱鹏四川大学

本文报导一种带有抗流槽的介质加载波导辐射器的研制结果。这种辐射器有相对均匀的加热图形,泄漏辐射较其它波导辐射器小,能满足临床治疗需要。用小探针法测试了这种辐射器在模拟肌肉内近场分布,结果与用温度计测出的辐射器加热后的温... 详细信息

本文报导一种带有抗流槽的介质加载波导辐射器的研制结果。这种辐射器有相对均匀的加热图形,泄漏辐射较其它波导辐射器小,能满足临床治疗需要。用小探针法测试了这种辐射器在模拟肌肉内近场分布,结果与用温度计测出的辐射器加热后的温度分布基本一致。实验还表明波导辐射器的抗流槽对宽边的泄漏辐射有明显抑制,但对窄边的泄漏抑制作用不很明显。

关键词： Waveguide radiator Microwave hyperthermia Reducing microwave leakage

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