检索结果-南通市图书馆

Congenital diarrhea in a newborn infant: A case report

World Journal of Clinical Pediatrics 2019年第3期8卷 43-48页

作者： Mehrin Sadiq Omer Choudry Arun K Kashyap Danitza M Velazquez Robert Wood Johnson University Hospital Rutgers University

BACKGROUND microvillus inclusion disease(MVID)is a rare autosomal recessive cause of severe congenital diarrhea with significant morbidity and *** treatment involves bowel *** diagnosis of this condition can be challenging and a few genetic panels are available for the identification of the most common *** present the case of an infant with MVID due to a mutation not reported in the literature *** SUMMARY We report the case of an infant transferred to our institution with severe diarrhea of unknown etiology,failure to thrive,and significant metabolic *** extensive work-up including stool studies for common gastrointestinal pathogens,abdominal ultrasound,esophagogastroduodenoscopy with duodenal biopsy and flexible sigmoidoscopy failed to reveal a *** dietary and formula regimens were introduced but all resulted in voluminous *** remained on total parenteral nutrition(TPN)for the duration of her hospital *** testing was done and she was subsequently found to have a novel mutation in the MYO5B gene[homozygous mutation for MYO5B c.1462del,p.(Ile488Leufs*93)]giving us the diagnosis of *** remains on TPN while awaiting bowel transplant at the time of the compilation of this case *** We report a novel mutation involved in MVID and highlight the importance of considering this disease when faced with a newborn presenting with life threatening *** the time of this publication,232 allelic variations of this gene(MIM#606540)exist in National Center for Biotechnology Information’s *** patient’s mutation has not been reported in literature as a cause of MVID.

关键词： Case report Congenital diarrhea microvillus inclusion disease Failure tothrive

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of dietary vanadium on small intestinal morphology in broilers

引用

Health 2012年第9期4卷 667-674页

作者： Kangping Wang Hengmin Cui Xi Peng Zhicai Zuo Jing Fang Junliang Deng Yuanxin Deng Wei Cui Bangyuan Wu Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province College of Veterinary Medicine Sichuan Agricultural University Ya’an China

The objective of this study was to determine the effects of dietary vanadium on small intestinal morphology of broilers by the methods of light microscopy (LM) and transmission electron microscopy (TEM). A total of 420 one-day-old avian broilers were divided into six groups (seven replicates in each group and ten broilers in each replicate) and fed on a control diet or the same diet supplemented with 5, 15, 30, 45 and 60 mg/kg vanadium in the form of ammonium metavanadate for 42 days. In comparison with those in the control group, the intestinal villus heights were decreased (P < 0.05 or P < 0.01) in the 30, 45 and 60 mg/kg groups, and crypt depths and villus height/crypt depth ratio were decreased in the 45 and 60 mg/kg groups. Ultrastructurally, the microvilli were apparently sparse and short, and the numbers of lysosomes were increased in abovementioned three intestines in the 45 and 60 mg/kg groups at 42 days of age. In conclusion, dietary vanadium in excess of 30 mg/kg could alter the villus height, crypt depth, villus height/crypt depth ratio and ultrastructure, which might impact the development of small intestines in broilers.

关键词： Vanadium Villus Crypt microvillus Intestine Broiler

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：