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Effect of Mineralized Layer Topographies on Stem cell behavior in microsphere scaffold

Journal of Materials Science & Technology 2016年第9期32卷 971-977页

作者： Jie Hou Huichang Gao Ying,jun Wang Delin Cheng Xiaodong Cao School of Materials Science and Engineering South China University of TechnologyGuangzhou 510641China National Engineering Research Center for Tissue Restoration and Reconstruction Cuangzhou 510006China Guangdong Province Key Laboratory of Biomedical Engineering South China University of TechnologyGuangzhou 510006China Center for Human Tissues and Organs Degeneration Shenzhen Institutes of Advanced TechnologyChinese Academy o~SciencesShenzhen 518055China

Modifying substrates through mineralization is a popular way to improve the osteogenic performance. Screening of the best mineralization characteristics on specific substrates for stem cells is meaningful but not fully studied. In this paper, poly（lactic-co-glycolic acid）/hydroxyapatite （PLGA[HA, PH） microsphere scaffolds with superficial pores were fabricated by a low-temperature fusion method. After the mineralization in the 5x stimulated body fluid （SBF） for 0, 7, 12 and 24 h, four mineralized scaffolds （MPH-0, MPH-7, MPH-12 and MPH-24） with different apatite topographies were obtained. It was found that the surface of MPH-7 was evenly decorated with abundant micro-pores, MPH-12 with dense and plain apatite layer, and MPH-24 with small spherical bumps. The responses of mouse bone mesenchymal stem cells （mBMSCs） to the four scaffolds were further studied. The results showed that MPH-7 and MPH-24 had more obvious effects on mBMSCs attachment, proliferation and differentiation than MPH-0 and MPH- 12. This work indicated that to obtain the maximum improvement, the mineralization characteristics had to be carefully chosen. This was noteworthy in the chemical modification of surfaces to form the functionalized scaffolds for bone repair.

关键词： microsphere scaffold mineralization topography cell behavior

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