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开发microplasmin用于卒中

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国外药讯 2003年第5期 11-11页

作者：王铮

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Pharmacologic vitreolysis:New strategy for treatment of anomalous vitreo-macular adhesion

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World Journal of Ophthalmology 2015年第3期5卷 99-105页

作者： Desislava N Koleva-Georgieva Clinic of Ophthalmology "St. George" Hospital Department of Ophthalmology Faculty of MedicineMedical University of Plovdiv

Persistent anomalous vitreo-macular adhesion(VMA) is a well-known factor, associated with a variety of sight threatening diseases- including macular hole, vitreo-macular traction syndrome, cystoid and diabetic macular edema, exudative age- related macular degeneration, myopic traction maculopathy and others. With the advent of optical coherence tomography our understanding of these pathologies and the ability of their early diagnosis has gone much far in the past two decades. The release of macular traction has been of exclusive surgical capability. Notwithstanding good results, vitrectomy is hampered by the inability of complete vitreo-retinal separation(i.e., smooth, bare internal limiting membrane), compulsory postoperative positioning in macular hole cases, surgical complications, and high costs. With aim to offer less invasive and safe treatment modality for anomalous VMA, investigators have made enormous progress in the past decade. Leading among the studied nonsurgical measures is the intravitreal application of pharmacologic agents for the induction of vitreo-retinal separation and vitreous liquefaction, a method termed pharmacologic vitreolysis. Several vitreolytic agents have been studied to date, the most potent among them proved to be plasmin. Recently, ocriplasmin(formerly known as microplasmin)- a more stable than plasmin recombinant product, proved to be safe and efficient in releasing VMA in large studies, and consequently received FDA approval. It's role in clinical practice is now in the process of being determined. This paper aims to review and summarize the current knowledge and status of investigation on this new approach for the treatment of VMA.

关键词： Pharmacologic vitreolysis Vitreo-macular adhesion Posterior vitreous detachment Macular hole microplasmin

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