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Gut microbiome:Linking together obesity,bariatric surgery and associated clinical outcomes under a single focus

World Journal of Gastrointestinal Pathophysiology 2022年第3期13卷 59-72页

作者： Konstantinos Georgiou Nikolay A Belev Tilemachos Koutouratsas Hector Katifelis Maria Gazouli The First Propaedeutic Surgical Unit Hippocrateion Athens General HospitalMedical SchoolNational and Kapodistrian University of AthensAthens 11527Greece Medical Simulation Training Center Research Institute of Medical University of Plovdivand UMPHAT“Eurohospital”Medical University of PlovdivPlovdiv 4002Bulgaria Basic Medical Sciences Medical SchoolNational and Kapodistrian University of AthensAthens 11527Greece

Obesity is increasingly prevalent in the post-industrial era,with increased mortality *** gut microbiota has a central role in immunological,nutritional and metabolism mediated functions,and due to its multiplexity,it is considered an independent *** high-throughput sequencing techniques have allowed phylogenetic exploration and quantitative analyses of gut microbiome and improved our current understanding of the gut microbiota in health and *** role in obesity and its changes following bariatric surgery have been highlighted in several *** to current literature,obesity is linked to a particular microbiota profile that grants the host an augmented potential for calorie release,while limited diversity of gut microbiome has also been ***,bariatric surgery procedures represent effective interventions for sustained weight loss and restore a healthier microbiota,contributing to the observed fat mass reduction and lean mass ***,newer evidence has shown that gut microbiota is only partially recovered following bariatric ***,several targets including FGF15/19(a gutderived peptide),could be responsible for the favorable metabolic changes of bariatric *** randomized controlled trials and larger prospective studies that include well-defined cohorts are required to better identify associations between gut microbiota,obesity,and bariatric surgery.

关键词： Bariatric surgery Obesity Gut microbiota micronutrient deficiency Probiotics

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