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Human Genotoxicity of Environmental Pollution from Electronic Waste

Human Genotoxicity of Environmental Pollution from Electroni...

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中国毒理学会放射毒理专业委员会第七次、中国毒理学会免疫毒理专业委员会第五次、中国环境诱变剂学会致突专业委员会第二次、中国环境诱变剂学会致畸专业委员会第二次、中国环境诱变剂学会致癌专业委员会第二次全国学术会议

作者： Qiang LIU Jia CAO Ke Qiu LI Xu Hong MIAO Guang LI Fei Yue FAN Yong Cheng ZhAO Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College,Tianjin Key Laboratory of Molecular Nuclear Medicine。300192 Tianjin, China

Background,aim, and scope It has been known that the pollutants of e-wastes can lead to severe pollution to the environment. It has been reported that about 50% to 80% electronic wastes from developed countries are exported to Asia and *** has become a major global environmental problem to deal with"E-wastes".Electronic waste recycling has remained primitive in Jinghai, China. This not only produces enormous environmental pollution, but also can bring about toxic or genotoxic effects on the human body, threatening the health of both current residents and future generations living in the local environment. The concentration of lead in the blood of children in the e-wastes polluted area in China is higher than that of the control area. But tittle is known on the cytogenetic effect to human beings caused by the pollution of e-wastes. In the present study, experiments have been performed to investigate the genetics of permanent residents of three villages with numerous electronic waste disposal sites, and to analyze the harmful effects of exposure to electronic waste. Materials and methods In total, 171 villagers (exposed group) were randomly selected from permanent residents of three villages located in Jinghai County of Tianjin, China, where there was massive disposal of electronic waste. Thirty villagers were selected from the neighboring towns without electronic waste disposal sites to serve as controls. Chromosomal aberrations and cytokinesis blocking micronucleus were performed to detect the cytogenetic effect, dic+r (dicentric and ring chromosome), monomer, fragments (acentric fragments, minute chromosomes and acentric rings), translocation, satellite, quadriradial, total aberrations and micronuclear rate were scored for each subject. DNA damage was detected using Comet assay, the DNA percentage in the comet tail (TDNA%), tail moment(TM) and Olive tail moment (OTM) were recorded to describe DNA damage to lymphocytes. Results The total chromosome aberration

关键词： Electronic waste Environment pollution Cytogenetics Single-cell gel electrophoresis Comet assay micronucleus analysis Chromosome aberration DNA damage

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Human Genotoxicity of Environmental Pollution from Electronic Waste

Human Genotoxicity of Environmental Pollution from Electroni...

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中国毒理学会第五次全国学术大会

作者： Qiang LIU~1,Ke Qiu LI~2,Jia CAO~1,Xu Hong MIAO~2,Guang LI~2,Fei Yue FAN~1,Yong Cheng ZhAO~1 1 Institute of Radiation Medicine,Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin Key Laboratory of Molecular Nuclear Medicine 2 Department of Biology of Tianjin Medical University

＜正＞Background,aim,and scope It has been known that the pollutants of e-wastes can lead to severe pollution to the *** has been reported that about 50%to 80%electronic wastes from developed countries are exported to Asia and *** has become a major global environmental problem to deal with"E-wastes".Electronic waste recycling has remained primitive in Jinghai,*** not only produces enormous environmental pollution,but also can bring about toxic or genotoxic effects on the human body,threatening the health of both current residents and future generations living in the local environment. The concentration of lead in the blood of children in the e-wastes polluted area in China is higher than that of the control *** little is known on the cytogenetic effect to human beings caused by the pollution of *** the present study,experiments have been performed to investigate the genetics of permanent residents of three villages with numerous electronic waste disposal sites,and to analyze the harmful effects of exposure to electronic waste.

关键词： Electronic waste Environment pollution Cytogenetics Single-cell gel electrophoresis Comet assay micronucleus analysis Chromosome aberration DNA damage

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