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Intravitreal long-term sustained ranibizumab delivery using injectable microgel-embedded hydrogel

Asian Journal of Pharmaceutical Sciences 2024年第5期19卷 126-138页

作者： Simin Lee Jun Young Park Hye Kyoung Hong Joo Young Son Byungwook Kim Jae Yong Chung Se Joon Woo Ki Dong Park Department of Molecular Science and Technology Ajou UniversitySuwon 16499Republic of Korea Department of Ophthalmology Seoul National University College of MedicineSeoul National University Bundang HospitalSeongnam 13620Republic of Korea Department of Ophthalmology Eulji University School of MedicineUijeongbu Eulji Medical CenterUijeongbu11759Republic of Korea Seoul National University Hospital Seoul 03080Republic of Korea Department of Clinical Pharmacology and Therapeutics Seoul National University College of MedicineSeoul National University Bundang HospitalSeongnam 13620Republic of Korea

Retinal vascular disease is the leading cause of visual *** intravitreal drug injections are the most suitable approach for addressing retinal disorders,existing clinical treatments necessitate repeated administration,imposing a substantial burden on patients with various intraocular *** study introduces an injectable and biodegradable hyaluronan microgel(Hm)-embedded gelatin-PEG-tyramine hydrogel(HmGh)designed for sustained intravitreal ranibizumab(RBZ)delivery to reduce patient burden and minimize the side effects associated with frequent *** exhibited a controlled RBZ loading capacity and release *** effectively controlled the initial burst release and overall release *** and cellular drug efficacy were also *** an animal study,HmGh maintained RBZ concentrations in the vitreous and retina for>120 *** studies showed that the half-life of RBZ-loaded HmGh in the vitreous and retina was 2.55 and 2.05 times longer than that of RBZ-loaded Hm and 9.58 and 38.46 times longer than that of RBZ ***,the initial RBZ elimination from HmGh to the aqueous humor was significantly reduced compared to that from Hm and RBZ *** degradation and safety were comprehensively evaluated using fundus imaging and histological *** conclusion,this injectable hydrogel is a promising prolonged drug delivery system for treating various posterior segment eye diseases.

关键词： Age-related macular degeneration Ranibizumab microgel-embedded hydrogel Long-term drug delivery Pharmacokinetics Biodegradation

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