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Anti-onchocerca Metabolites from Cyperus articulatus:Isolation,In Vitro Activity and In Silico‘Drug-Likeness’

Natural Products and Bioprospecting 2014年第4期4卷 243-249页

作者： Jonathan Alunge Metuge Smith B.Babiaka James A.Mbah Fidele Ntie-Kang Godfred A.Ayimele Fidelis Cho-Ngwa ANDI Centre of Excellence Department of Biochemistry and Molecular BiologyFaculty of ScienceUniversity of BueaP.O.Box 63BueaCameroon Department of Chemistry Faculty of ScienceUniversity of BueaP.O.Box 63BueaCameroon Chemical and Bioactivity Information Centre Chemistry DepartmentFaculty of ScienceUniversity of BueaP.O.Box 63BueaCameroon

The aims of this investigation were to isolate active ingredients from the roots/rhizomes of Cyperus articulatus used as herbal medicine in Cameroon for the treatment of human onchocerciasis and to assess the efficacy of the metabolites on the Onchocerca worm.The antifilarial activity was evaluated in vitro on microfilariae(Mfs)and adult worms of the bovine derived Onchocerca ochengi,a close relative of Onchocerca volvulus.Cytotoxicity was assessed in vitro on monkey kidney epithelial cells.The structures of the active compounds were determined using spectroscopic methods and their drug-likeness evaluated using Lipinski parameters.Two secondary metabolites,AMJ1[containing mustakone(1)as the major component]and linoleic acid or(9Z,12Z)-octadeca-9,12-dienoic acid(2)were isolated.Both compounds were found to kill both the microfilariae and adult worms of O.ochengi in a dose dependent manner.The IC50s for AMJ1 were 15.7 lg/mL for Mfs,17.4 lg/mL for adult males and 21.9 lg/mL for adult female worms while for linoleic acid the values were,15.7 lg/mL for Mfs,31.0 lg/mL for adult males and 44.2 lg/mL for adult females.The present report provides the first ever evidence of the anti-Onchocerca efficacy of AMJ1 and linoleic acid.Thus,these secondary metabolites may provide a lead for design and development of new antifilarial agents.

关键词： Cyperus articulates Linoleic acid microfilariae Mustakone Onchocerca ochengi Onchocerca volvulus

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Mansonella ozzardi parasitic infestation in the orbit

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International Journal of Ophthalmology(English edition) 2017年第10期10卷 1630-1632页

作者： Princeton Lee Aruna Dharmasena Katherine MB Ajdukiewicz Sajid Ataullah Department of Oculoplastic Lacrimal and Orbital SurgeryManchester Royal Eye Hospital Department of Infectious Disease & Tropical Medicine North Manchester General Hospital

Mansonella ozzardi, one of many filarial nematodes exclusively found in parts of Latin America, is one of two Mansonella sp which cause mansonelliasis, an infestation first described by Sir Patrick Manson, the founder... 详细信息

关键词： BRAZILIAN AMAZON ONCHOCERCA-VOLVULUS PERIPHERAL-BLOOD SKIN BIOPSIES IVERMECTIN microfilariae INFECTION PCR NEMATODA VECTORS

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Potential factors influencing lymphatic filariasis transmission in"hotspot"and"control"areas in Ghana:the importance of vectors

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Infectious Diseases of Poverty 2019年第1期8卷 45-55页

作者： Sellase Pi-Bansa Joseph Harold Nyarko Osei Kwadwo Kyeremeh Frempong Elizabeth Elhassan Osei Kweku Akuoko David Agyemang Collins Ahorlu Maxwell Alexander Appawu Benjamin Guibehi Koudou Michael David Wilson Dziedzom Komi de Souza Samuel Kweku Dadzie Jurg Utzinger Daniel Adjei Boakye Swiss Tropical and Public Health Institute BaselSwitzerland University of Basel BaselSwitzerland Noguchi Memorial Institute for Medical Research College of Health SciencesUniversity of GhanaLegonGhana Department of Animal Biology and Conservation Science University of GhanaLegonGhana SightSavers International Ghana OfficeAccraGhana African Regional Postgraduate Programme in Insect Science University of GhanaLegonGhana Vector Biology Department Liverpool School of Tropical MedicineLiverpoolUK Centre Suisse de Recherches Scientifiques en Cote d'Ivoire AbidjanCote d'Ivoire

Background:Mass drug administration(MDA)programmes for the control of lymphatic filariasis in Ghana,have been ongoing in some endemic districts for 16 years.The current study aimed to assess factors that govern the success of MDA programmes for breaking transmission of lymphatic filariasis in Ghana.Methods:The study was undertaken in two"hotspot"districts(Ahanta West and Kassena Nankana West)and two control districts(Mpohor and Bongo)in Ghana.Mosquitoes were collected and identified using morphological and molecular tools.A proportion of the cibarial armatures of each species was examined.Dissections were performed onAnopheles gambiae for filarial worm detection.A questionnaire was administered to obtain information on MDA compliance and vector control activities.Data were compared between districts to determine factors that might explain persistent transmission of lymphatic filariasis.Results:High numbers of mosquitoes were sampled in Ahanta West district compared to Mpohor district(F=16.09,P=0.002).There was no significant difference between the numbers of mosquitoes collected in Kassena Nankana West and Bongo districts(F=2.16,P=0.185).Mansonia species were predominant in Ahanta West district.An.coluzzii mosquitoes were prevalent in all districts.An.melas with infected and infective filarial worms was found only in Ahanta West district.No differences were found in cibarial teeth numbers and shape for mosquito species in the surveyed districts.Reported MDA coverage was high in all districts.The average use of bednet and indoor residual spraying was 82.4 and 66.2%,respectively.There was high compliance in the five preceding MDA rounds in Ahanta West and Kassena Nankana West districts,both considered hotspots of lymphatic filariasis transmission.Conclusions:The study on persistent transmission of lymphatic filariasis in the two areas in Ghana present information that shows the importance of local understanding of factors affecting control and elimination of lymphatic filariasis.Unlike Kassena Nankana West district

关键词： Ghana Hotspots Lymphatic filariasis Mass drug administration microfilariae Systematic non-compliance Vector control

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长爪沙鼠体内周期型马来丝虫微丝蚴的季节周期性

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Current Zoology 1983年第2期29卷 180-184页

作者： Department of Parasitology, Zunyi Medical College, Guizhou 遵义医学院寄生虫学教研室

微丝蚴在外周血液中的出现,不仅有明显的日夜周期性,还有明显的季节周期性,后一现象不仅发生在马来丝虫(陆素筠,1956)或班氏丝虫的患者(Brengues等,1975),也见于有犬恶丝虫或匐形恶丝虫寄生的犬体(Kume和Ohishi,1965;Katamme等,1970;Aok... 详细信息

微丝蚴在外周血液中的出现,不仅有明显的日夜周期性,还有明显的季节周期性,后一现象不仅发生在马来丝虫(陆素筠,1956)或班氏丝虫的患者(Brengues等,1975),也见于有犬恶丝虫或匐形恶丝虫寄生的犬体(Kume和Ohishi,1965;Katamme等,1970;Aoki,1971;Cancrml,1975a、b;Sawyer,1975)。本文报道实验感染周期型马来丝虫的长爪沙鼠体内微丝蚴的季节周期性。

关键词： Meriones unguiculatus Brugia malayi Periodicity microfilariae Rhythm

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