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Qualitative phytochemical screening and evaluation of anti-inflammatory, analgesic and antipyretic activities of microcos paniculata barks and fruits

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Journal of Integrative Medicine 2015年第3期13卷 173-184页

作者： Md.Abdullah Aziz Department of Pharmacy Stamford University Bangladesh

OBJECTIVE： The main objectives of this study were to qualitatively evaluate the profile of phytochemical constituents present in methanolic extract of microcos paniculata bark（BME） and fruit（FME）, as well as to evaluate their anti-inflammatory, analgesic and antipyretic activities.METHODS： Phytochemical constituents of BME and FME were determined by different qualitative tests such as Molisch’s test, Fehling’s test, alkaloid test, frothing test, Fe Cl3 test, alkali test, Salkowski’s test and Baljet test. The anti-inflammatory, analgesic and antipyretic activities of the extracts were evaluated through proteinase-inhibitory assay, xylene-induced ear edema test, cotton pellet-induced granuloma formation in mice, formalin test, acetic acid-induced writhing test, tail immersion test and Brewer’s yeastinduced pyrexia in mice.RESULTS： M. paniculata extracts revealed the presence of carbohydrates, alkaloids, saponins, tannins, flavonoids and triterpenoids. All of the extracts showed significant（P〈0.05, vs aspirin group） proteinaseinhibitory activity, whereas the highest effect elicited by plant extracts was exhibited by the BME（75.94% proteinase inhibition activity） with a half-maximal inhibitory concentration（IC50） of 61.31 μg/m L. Each extract at the doses of 200 and 400 mg/kg body weight showed significant（P〈0.05, vs control） percentage inhibition of ear edema and granuloma formation. These extracts significantly（P〈0.05, vs control） reduced the paw licking and abdominal writhing of mice. In addition, BME 400 mg/kg, and FME at 200 and 400 mg/kg showed significant（P〈0.05, vs control） analgesic activities at 60 min in the tail immersion test. Again, the significant（P〈0.05, vs control） post-treatment antipyretic activities were found by BME 200 and 400 mg/kg and FME 400 mg/kg respectively.CONCLUSION： Study results indicate that M. paniculata may provide a source of plant compounds with anti-inflammatory, analgesic and antipyretic activities.

关键词： phytochemical screening agents,anti-inflammatory analgesics antipyretic agents microcos paniculata medicine,herbal

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Chemical constituents with free-radical-scavenging activities from the stem of microcos paniculata

Chemical constituents with free-radical-scavenging activitie...

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2010年全国中药学术研讨会

作者： Hua Fan~1,Guang-Zhong Yang1,* Tong Zheng1,Zhi-nan Mei1,Xiang-ming Liu1,Yu Chen2, Su Chen1 1 College of Pharmacy,South Central University for Nationalities,Wuhan 430074,P.R.China 2 College of Chemistry and Material Sciences,South Central University for Nationalities,Wuhan 430074,P.R.China

The free-radical-scavenging activities of various solvent extracts of microcos paniculata were evaluated through in vitro model systems,such as 1,1-diphenyl-2-picrylhydrazyl(DPPH), 2,2’-azino-bis-(3-ethylbenzothiazoline-6-sulfonate)(ABTS) and Co(Ⅱ) EDTA-induced luminol chemiluminescence by flow injection.In all these three systems the ethyl acetate(EtOAc) extract showed the highest free-radical-scavenging activity compared with the other three extracts. Free-radical-scavenging assay-guided chromatographic separation of the EtOAc extract,using a normal-phase and reverse-phase silica gel column chromatography yielded five compounds,a new triterpene named 3β-O-p-hydroxy-E-cinnamoyloxy-2α,23-dihydroxy-olean-12-en-28-oate(1), together with four known compounds,epicatechin(2),3-trans-feruloyl maslinic acid(3),maslinic acid(4) and sucrose(5),the above compounds were identified by spectroscopic methods.Among them,Spectral data of compound 1 was presented for the first time,and all over compounds were isolated from microcos paniculata for the first time.Notably,compound 2 presented as a powerful scavenger with significant free-radical-scavenging activity which is similar to that of standard antioxidant ascorbic acid and therefore may be a promising source of natural antioxidants.

关键词： microcos paniculata free-radical-scavenging activities DPPH ABTS Co（Ⅱ） EDTA-induced luminol chemiluminescence by flow injection

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