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Structural and functional characteristics of microbiota in oropharynx of sub-healthy children with gastrointestinal heat retention syndrome differentiated by traditional Chinese medicine

引用

Journal of Traditional Chinese Medical Sciences 2022年第3期9卷 230-236页

作者： Jianhua Zhen He Yu Xiaofei Li Fei Dong Zi'an Zheng Xueyan Ma Yuxiang Wan Tiegang Liu Lu Fan Xiaohong Gu School of Life Sciences Beijing University of Chinese MedicineBeijing102488China School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing102488China Department of Traditional Chinese Medicine People's Hospital of Laoling CountyLaoling253600China Institute of Chinese Medicine Epidemic Disease Beijing University of Chinese MedicineBeijing102488China School of Basic Medicine Guizhou University of Traditional Chinese MedicineGuiyang550025China Department of Acupuncture and Mini-invasive Oncology Beijing University of Chinese Medicine Third Affiliated HospitalBeijing100029China Student Affairs Department Beijing University of Chinese MedicineBeijing102488China

Objective:To explore the structural and functional characteristics of microbiota in oropharynx of subhealthy children with gastrointestinal heat retention syndrome(GHRS)differentiated by traditional Chinese medicine,and screen the biometric operational taxonomic units(OTUs)to assist the clinical ***:We recruited children according to the“GHRS diagnostic scale”,collected their oropharyngeal swabs,and sequenced the 16 SrDNA V4 *** described the bacterial structure with alpha-indexes,beta-distances,and relative abundances;moreover,we screened the differential genera/OTUs with Wilcoxon rank-sum test,Metagenome Seq analysis,and linear discriminant analysis effect size(LEf Se)analysis,in which biometric OTUs were selected to construct the receiver operating characteristic curve to verify the diagnostic *** bacterial function was predicted with Kyoto Encyclopedia of Genes and Genomes pathways according to 16S rDNA gene by using Phylogenetic Investigation of Communities by Reconstruction of Unobserved ***:The study population was composed of 10 children with GHRS and 10 healthy control *** children were more likely to overeat(gluttony,P=.033).Alpha-indexes,such as Sobs,abundancebased coverage estimator,Bootstrap,and Qstat,were significantly higher in the GHRS group,while betadistances did not exhibit any significant intergroup *** were 9 differently distributed nonpredominant genera between the groups in Wilcoxon rank-sum test,as well as 13 non-predominant genera in Metagenome Seq analysis and 3 non-predominant OTUs in LEfSe ***44 and OTU196 were used to construct the receiver operating characteristic curve,and the area under curve was *** functions showed that pathways related to oxidative phosphorylation and carbon metabolism were enriched in healthy control samples,while the pathway related to renin secretion was remarkably enriched in GHRS ***:Unique oropharyngeal microbial s

关键词： Sub-health Gastrointestinal heat retention syndrome Traditional Chinese medicine microbiota in oropharynx 16S rDNA sequencing Children Differential genus Biometric operational taxonomic units

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