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Efficacy of Cyanoacrylate Tissue Adhesive Application in the Management of Corneal Perforations at Preah Ang Duong Hospital in Cambodia

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Open Journal of Ophthalmology 2024年第1期14卷 44-54页

作者： Guechlaing Chea Amarin Mar Saly Saint Remy Tor Ponndara Ith Piseth Kong Ophthalmology Department Preah Ang Duong Hospital Phnom Penh Cambodia Faculty of Medicine University of Health Sciences Phnom Penh Cambodia

Purpose: The study was to evaluate the efficacy of cyanoacrylate tissue adhesive (CTA) application in corneal perforations. Method: This was a prospective study on 20 patients of corneal perforations who received cyanoacrylate tissue adhesive application as treatment between March 2021 and March 2022 at Preah Ang Duong Hospital. The primary outcome measure was success rate of CTA application, while the secondary outcome was to measure postoperative best-corrected visual acuity (BCVA) and ocular complications. Results: The mean age of patients was 44.15 ± 16.05 years old and 7 (35%) were female. Causes of perforation were microbial infection in 12 patients (60%), trauma in 5 patients (25%), and sterile melting in 3 patients (15%). The perforation of size smaller than 1.5 mm was in 8 patients (40%) while 12 patients (60%) had perforated size between 1.5 mm to 3 mm. The perforation was 60% (12 patients) central, 25% (5 patients) paracentral, and 15% (3 patients) peripherally. Out of 20 patients, 5 patients (25%) received CTA application more than 1 time. The mean glue retention was 57.60 ± 31.84 days. Success rate of glue application (defined as intact globe without surgical intervention regardless of number of CTA applications) was 85%. At the last visit, 7 patients (35%) had BCVA of 6/120 or better. Common complications were uveitis (45%), ocular hypertension (30%), cataract (25%) and neovascularization (20%). No serious complications were found. Conclusion: Cyanoacrylate tissue adhesive is an effective treatment option in sealing corneal perforations with no serious complications. .

关键词： Cyanoacrylate Tissue Adhesive Corneal Perforation microbial infection Sterile Melting

Corrosion in Mg-alloy biomedical implants-the strategies to reduce the impact of the corrosion inflammatory reaction and microbial activity

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Journal of Magnesium and Alloys 2022年第12期10卷 3306-3326页

作者： Soumya Saha Widya Lestari Caroline Dini Murni Nazira Sarian Hendra Hermawan Valentim A.R.Barão Cortino Sukotjo Christos Takoudis Department of Biomedical Engineering University of Illinois at ChicagoChicagoUnited States Fundamental Dental and Medical Sciences Department Kulliyyah of DentistryInternational Islamic University MalaysiaKuantanMalaysia Department of Prosthodontics and Periodontology Piracicaba Dental SchoolUniversity of Campinas(UNICAMP)PiracicabaBrazil Institute of Systems Biology(INBIOSIS) Universiti Kebangsaan MalaysiaBandar Baru BangiSelangor 43600Malaysia Department of Mining Metallurgical and Materials EngineeringLaval UniversityQuebec CityQC G1V 0A6Canada Department of Restorative Dentistry University of Illinois at Chicago College of DentistryChicagoUnited States Department of Chemical Engineering University of Illinois at ChicagoChicagoUnited States

The most common complication of orthopedic surgery is implant failure, which can result in catastrophic injury and a significant financial burden for patients. Implant failure can be caused by a variety of factors, the most common of which are peri–implant infection(or implantrelated infection), excessive inflammatory response which caused pain and aseptic loosening. Orthopedic surgeons now have a variety of options for treating these issues, including revision surgery, which has demonstrated to be effective. If excessive inflammatory reaction caused by the corrosion and peri–implant infection can be avoided, it will be of enormous social benefits. This review will provide a summary of corrosion and the inflammation reactions due to the corrosion and antimicrobial properties of Mg alloy-based implants covering both in vitro and in vivo studies. The strategies on hindering/overcoming the excessive inflammatory response and enhancing the antimicrobial activity are discussed in this review.

关键词： Mg-alloy implants review Corrosion and inflammation microbial infection

Two-phase Releasing Immune-stimulating Composite Orchestrates Protection against microbial infections

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Two-phase Releasing Immune-stimulating Composite Orchestrate...

Comparative analysis of peptidoglycan recognition proteins in endoparasitoid wasp Microplitis mediator

第十四届全国免疫学学术大会

作者： He Zhao Jian Wang Children’s Hospital of Soochow University

Sepsis,a syndrome of acute organ dysfunction induced by various infections,could lead to a very high mortality in hospitals despite the development of advanced medical ***,a type of two-phase releasing immune-stimulating composite is developed by mixing alginate(ALG) with muramyl dipeptide(MDP) and the nanoparticle formulation of monophosphoryl lipid A(MPLA),the latter two are immunomodulatory agents with different release rates from the formed ALG *** obtained two phase-releasing composite could provide instantaneous sepsis protection by the rapid release of MDP to enhance the phagocytic and bactericidal function of *** on,such composite could further offer long-term sepsis protection by the sustained release of MPLA to continuously activate the immune system,via up-regulating the production of various pro-inflammatory cytokines,promoting the polarization of macrophages,and increasing the percent of natural killer(NK) cells in the lesion after sepsis *** survived from sepsis challenge after such treatment could resist a second ***,treatment with our composite could increase the mouse survival rate in a cecal ligation and puncture(CLP) induced polymicrobial sepsis *** work provides an easy-translatable immune-stimulating formulation for effective protection against sepsis under various triggering *** strategy may be promising for long-term broad prevention against various infections,and could potentially be used to protect medical workers under a new pandemic before a reliable vaccine is available.

关键词： Two-phase releasing composite immune regulation microbial infection bacterial protection cecal ligation and puncture protection

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Insect Science 2017年第1期24卷 2-16页

作者： Rui-Juan Wang Zhe Lin Hong Jiang Jiancheng Li Tusar T. Saha Ziyun Lu Zhiqiang Lu Zhen Zou Department of Entomology College of Plant Protection Northwest A&F University Yangling Shaanxi State Key Laboratory of Integrated Management of Pest Insects and Rodents Institute of Zoology Chinese Academy of Sciences Beijing Key Laboratory of Integrated Pest Management on Crops in Nor/hem Region of North China Ministry of Agriculture IPM Center of Hebei Province Institute of Plant Protection Hebei Academy of Agriculture and Forestry Sciences Baoding China Department of Entomology University of California Riverside CA USA

Peptidoglycan recognition proteins （PGRPs） are a family of innate immune receptors that specifically recognize peptidoglycans （PGNs） on the surface of a number of pathogens. Here, we have identified and characterized six PGRPs from endoparasitoid wasp, Microplitis mediator （MmePGRPs）. To understand the roles of PGRPs in parasitoid wasps, we analyzed their evolutionary relationship and orthology, expression profiles during different developmental stages, and transcriptional expression following infection with Gram-positive and -negative bacteria and a fungus. MmePGRP-S1 was significantly induced in response to pathogenic infection. This prompted us to evaluate the effects of RNA interference mediated gene specific knockdown ofMmePGRP-S1. The knockdown of MmePGRP-S1 （iMmePGRP-S1） dramatically affected wasps＇ survival following challenge by Micrococcus luteus, indicating the involvement of this particular PGRP in immune responses against Gram-positive bacteria. This action is likely to be mediated by the Toll pathway, but the mechanism remains to be determined. MmePGRP-S 1 does not play a significant role in anti-fungal immunity as indicated by the survival rate of iMmePGRP-S wasps. This study provides a comprehensive characterization of PGRPs in the economically important hymenopteran species M. mediator.

关键词： endoparasitoid wasp insect immunity microbial infection Microplitis mediator peptidoglycan recognition protein

Inhibition of bacterial adhesion and biofilm formation by a textured fluorinated alkoxyphosphazene surface

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Bioactive Materials 2021年第2期6卷 447-459页

作者： Meixian Tang Chen Chen Jieru Zhu Harry R.Allcock Christopher A.Siedlecki Li-Chong Xu Department of Biomedical Engineering The Pennsylvania State UniversityUniversity ParkPA16802United States Department of Chemistry The Pennsylvania State UniversityUniversity ParkPA16802United States Department of Surgery The Pennsylvania State UniversityCollege of MedicineHersheyPA17033United States

The utilization of biomaterials in implanted blood-contacting medical devices often induces a persistent problem of microbial infection,which results from bacterial adhesion and biofilm formation on the surface of *** this research,we developed new fluorinated alkoxyphosphazene materials,specifically poly[bis(octafluoropentoxy)phosphazene](OFP)and crosslinkable OFP(X–OFP),with improved mechanical properties,and further modified the surface topography with ordered pillars to improve the antibacterial *** X–OFP materials,X–OFP3.3,X–OFP8.1,X–OFP13.6,with different crosslinking densities were synthesized,and textured films with patterns of 500/500/600 nm(diameter/spacing/height)were fabricated via a two stage soft lithography molding *** with 3 bacterial strains:Staphylococcal epidermidis,Staphylococcal aureus,and Pseudomonas aeruginosa showed that bacterial adhesion coefficients were significantly lower on OFP and X–OFP smooth surfaces than on the polyurethane biomaterial,and surface texturing further reduced bacterial adhesion due to the reduction in accessible surface contact *** the anti-bacterial adhesion effect shows a positive relationship with the crosslinking *** formation on the substrates was examined using a CDC biofilm reactor for 7 days and no biofilm formation was observed on textured X–OFP *** results suggested that the combination of fluorocarbon chemistry and submicron topography modification in textured X–OFP materials may provide a practical approach to improve the biocompatibility of current biomaterials with significant reduction in risk of pathogenic infection.

关键词： Fluorinated polyphosphazene Textured surface Crosslinking Anti-bacterial adhesion Anti-biofilms microbial infection

Resilient expression of Rana dybowskii skin functional proteins stressed in the mi-crobe

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Resilient expression of Rana dybowskii skin functional prote...

Analysis of skin and secretions of Rana Dybowskii exposed to Staphylococcus aureus or Escherichia coli identifies immune response proteins

中国生理学会第24届全国会员代表大会暨生理学学术大会

作者： Jing-Yu Zhang Long-Hui Chai Bo-Hong Guo Xiang-Hong Xiao Xue-Can Shi Shu-Dong Niu Northeast Forestry University

The skin glands of Ranidae are a rich source of antimicrobial *** this study,the genomic RNA of Rana dybowskii was extracted from its skin while under Rana grylio virus *** new c DNA sequences encoding 5 mature peptides,Ranatuerin-2YJ（GLMDIFKVAVNKLLAAGMNKPRCKAAHC）,Dybowskin-YJb（ⅡPLPLGYFAKKP）,Dybowskin-YJa（ⅡPLPLGYFAKKKKKKDPVPLDQ）,Temperin-YJa（VLPLLETCSMTCWENNQTFGK）,and Temperin-YJb（VLPLVGNLLNDLLGK）,were obtained by reverse transcription polymerase chain reaction with a pair of degenerate primers designed according to the conserved terminal sequences of c DNA encoding antimicrobial peptide precursors of genus *** antimicrobial activities of the peptides were analyzed,and the results demonstrated that all these peptides showed a significant anti-Rana grylio virus activity,and the virus was gradually cleared with the increase in gene *** the 5 peptides obtained in this work,Ranatuerin-2YJ also showed a broad-spectrum anti-Gram-positive bacteria and anti-Gram-negative bacteria activity with a minimal inhibitory concentration of 22.5 microg/m L and 7.64%hemolysis activity,both of which were significantly lower（p＜0.05）than that of the other ***,Ranatuerin-2YJ was widely distributed in the skin,liver,spleen,and blood of ***,while the other 4 peptides could only be cloned from the skin,indicating that the Ranatuerin-2YJ in vivo plays an important role in the protection against pathogen invasion.

关键词： Immune responses microbial infection Proteomic analysis Rana dybowskii

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Analysis of skin and secretions of Rana Dybowskii exposed to...