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Targeted therapy in gastric cancer:Personalizing cancer treatment based on patient genome

World Journal of Gastroenterology 2014年第8期20卷 2042-2050页

作者： Sun Min Lim Jae Yun Lim Jae Yong Cho Division of Medical Oncology Department of Internal MedicineSeverance HospitalYonsei University College of MedicineSeoul 135-720South Korea Department of Medical Oncology Gangnam Severance HospitalYonsei University College of MedicineSeoul 135-720South Korea

Gastric cancer is the second leading cause of cancerrelated deaths *** cytotoxic chemotherapy has limited efficacy for metastatic gastric cancer,with an overall survival of approximately ten *** advances in high-throughput technologies have enabled the implementation of personalized cancer therapy for high-risk *** use of such high-throughput technologies,including microarray and next generation sequencing,have promoted the discovery of novel targets that offer new treatment strategies for patients lacking other therapeutic *** molecular pathways are currently under investigation as therapeutic targets in gastric cancer,including those related to the epidermal growth factor receptor family,the mesenchymal-epithelial transition factor axis,and the phosphatidylinositol 3-kinase-AKTmammalian target of rapamycin *** in molecular diagnostic tools further support the discovery of new molecular *** exist,however;not all patients can be tested for biomarkers,and numerous challenges hamper implementation of targeted therapy in clinical ***,the scale of tumor genomic profiling is rapidly outpacing our ability to appropriately synthesize all the information in order to optimally refine patient ***,clinicians must continue to educate themselves regarding new tools and frameworks,and to utilize multidisciplinary team science,comprised of oncologists,geneticists,pathologists,biologists and bioinformaticians,to successfully implement this genomic approach therapeutically.

关键词： Gastric cancer Targeted therapy Biomarker microarr

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