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micro-ecology restoration of colonic inflammation by in-Situ oral delivery of antibody-laden hydrogel microcapsules

Bioactive Materials 2022年第9期7卷 305-315页

作者： Bo Li Xin Li Xiaodong Chu Pengcheng Lou Yin Yuan Aoxiang Zhuge Xueling Zhu Yangfan Shen Jinghua Pan Liyuan Zhang Lanjuan Li Zhongwen Wu State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou310003China Research Units of Infectious Disease and microecology Chinese Academy of Medical SciencesBeijing100730China Department of Pharmacology The First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou310003China Department of General Surgery The First Affiliated Hospital of Jinan UniversityGuangzhou510632China School of Engineering and Applied Sciences Harvard University9 Oxford StCambridgeMAUSA02138 School of Petroleum Engineering State Key Laboratory of Heavy Oil ProcessingChina University of Petroleum(East China)Qingdao266580China

In-situ oral delivery of therapeutic antibodies,like monoclonal antibody,for chronic inflammation treatment is the most convenient approach compared with other administration ***,the abundant links between the gut microbiota and colonic inflammation indicate that the synergistic or antagonistic effect of gut microbiota to colonic ***,the antibody activity would be significantly affected while transferring through the gastrointestinal tract due to hostile ***,these antibodies have short serum half-lives,thus,require to be frequently administered with high doses to be effective,leading to low patient ***,we develop a strategy utilizing thin shell hydrogel microcapsule fabricated by microfluidic technique as the oral delivering *** encapsulating antibodies in these microcapsules,antibodies survive in the hostile gastrointestinal environment and rapidly release into the small intestine through oral administration route,achieving the same therapeutic effect as the intravenous injection evaluated by a colonic inflammation disease ***,the abundance of some intestinal microorganisms as the indication of the improvement of inflammation has remarkably altered after in-situ antibody-laden microcapsules delivery,implying the restoration of micro-ecology of the *** findings prove our microcapsules are exploited as an efficient oral delivery agent for antibodies with programmable function in clinical application.

关键词： Antibody oral delivery Hydrogel thin-shell microcapsules microfluidic Gut microbiota Colonic inflammation micro-ecology restoration

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