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Exposure to methylparaben at environmentally realistic concentrations significantly impairs neuronal health in adult zebrafish

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Journal of Environmental Sciences 2023年第10期132卷 134-144页

作者： Chenyan Hu Yachen Bai Baili Sun Xiangzhen Zhou Lianguo Chen School of Chemistry and Environmental Engineering Wuhan Institute of TechnologyWuhan 430072China State Key Laboratory of Freshwater Ecology and Biotechnology Institute of HydrobiologyChinese Academy of SciencesWuhan 430072China University of Chinese Academy of Sciences Beijing 100049China

methylparaben(MeP)is an emerging aquatic pollutant that is found to impact neural ***,it still lacks a comprehensive understanding about its *** present study exposed adult zebrafish to environmentally realistic concentrations(0,1,3,and 10μg/L)of MeP for 28 days,with objectives to elucidate the neurotoxic effects *** profiling found that MeP pollutant induced distinct mechanism of neurotoxicity as a function of *** pollutant appeared to preferentially target the neurotransmission cascade via synapse *** male brain,glutamatergic neural signaling was enhanced by 10μg/L of MeP in characteristics of higher glutamate neurotransmitter content(by 61.9%)and up-regulated glutamate receptor expression by 2.6-fold relative to the *** MeP-exposed female brain,biomarker proteins of synapse formation and regeneration had significantly lower abundance,accounting for the blockage of synaptic ***,under the stress of MeP pollutant,both male and female zebrafish initiated a negative feedback mechanism along stress neuroendocrine axis by down-regulating the transcriptions of corticotropin-releasing hormone and its binding protein,which subsequently decreased blood cortisol *** subchronic exposure also disturbed innate immune *** particular,significant increases in lipopolysaccharide(LPS)content by 15.6%were caused by MeP exposure in male brain,thereby inducing the synthesis of pro-inflammatory *** contrast,female brain was able to adaptively up-regulate the protein expression of blood brain barrier to inhibit the infiltration of LPS endotoxin into ***,the present findings pinpoint the potent neurotoxicity of MeP pollutant even at environmentally realistic concentrations.

关键词： methylparaben Neurotoxicity Synapse Stress Inflammation

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Stability Indicating RP-UPLC Method for Quantification of Glycopyrrolate, methylparaben and Propylparaben Assay in Liquid Oral Formulation

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American Journal of Analytical Chemistry 2022年第12期13卷 538-552页

作者： Sreenivas Pippalla Arjuna Rao Nekkalapudi Suresh Babu Jillellamudi Sikkim Professional University Gangtok India Asphar Research Labs Pvt. Ltd. Hyderabad India

Stability indicating RP-UPLC technique was developed for the simultaneous quantification of glycopyrrolate, methylparaben, and propylparaben in glycopyrrolate oral solution. The method was established by using gradient UPLC and a Waters Acquity UPLC BEH C18, 100 mm 2.1 mm, i.d 1.7 μm particle size column with a gradient program of mobile phase A and mobile phase B with a flow rate of 0.25 mL/minute, UV wavelength detection at 222 nm, column temperature of 40°C, injection volume of 2 μL, mobile phase A contains 0.05% trifluoro acetic acid in water and Acetonitrile (90:10) v/v and mobile phase-B contains 0.05% trifluoro acetic acid in water and Acetonitrile (10:90) v/v. The current research describes a single UPLC method for developing an assay method for Glycopyrrolate Oral solution that includes Glycopyrrolate (Active), methylparaben (Preservative), and Propylparaben (Preservative). The assay method was validated in accordance with ICH guidelines. The retention times of glycopyrrolate, methyl paraben and propylparaben were 6.051 min, 3.458 min and 8.095 min, respectively. Linearity range of glycopyrrolate, methyl paraben and propylparaben were in the range of 4 - 32 μg per mL, 35 - 290 μg per mL and 4 - 32 μg per mL, respectively. Recovery of glycopyrrolate, methylparaben and propylparaben ranged from 100.1% to 98.9%, 100.2% - 100.8%, and 100.2% - 100.8%. Validation of analytical method demonstrated that the method is suitable, specific, linear, accurate, precise, rugged and stability indicating for estimating three components in the pharmaceutical dosage form.

关键词： Glycopyrrolate Oral Solution UPLC Assay methylparaben Propylparaben

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Adsorption of Pharmaceuticals and Personal Care Products on Granular Activated Carbon

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Journal of Surface Engineered Materials and Advanced Technology 2016年第4期6卷 183-200页

作者： Nasly Y. Delgado Alberto L. Capparelli Damián J. Marino Agustín F. Navarro Gustavo A. Peñuela Alicia E. Ronco Centro de Investigaciones del Medio Ambiente Facultad de Ciencias Exactas Universidad Nacional de la Plata (UNLP) La Plata Argentina Consejo Nacional de Investigaciones Científicas y Técnicas La Plata Argentina División Fisicoquímica Facultad de Ciencias Exactas UNLP La Plata Argentina Departamento de Ingeniería Química Facultad de Ingeniería UNLP La Plata Argentina Grupo GDCON Universidad de Antioquia Medellín Colombia

We investigated the adsorption to granular activated carbon of two pharmaceuticals (carbamazepine and sildenafil citrate) and a personal-care product (methylparaben) in aqueous solution, characterized the carbon, and evaluated its influence on the kinetics and adsorption equilibrium of the compounds under study. We adjusted data for the analysis of equilibrium to Langmuir and Freundlich models of adsorption isotherms and described adsorption rate using pseudo first- and second-order models;that same analysis was made on the basis of the behavior of the initial rate. In addition, we analyzed the potentiality of a nonlinear adjustment for studying kinetics and equilibrium of adsorption, an approach requiring neither knowledge of equilibrium conditions nor a-priori hypothetical suppositions regarding the order of reaction. The results indicated that the nonlinear model was capable of describing adsorption kinetic behavior, in order to determine concentrations adsorbed at equilibrium, adsorption rates of the system, maximum adsorption capacity, and global rate constant. Granular carbon exhibited an adsorption capacity for carbamazepine and methylparaben of ca. 323 mg/g and for sildenafil citrate of ca. 142 mg/g, though with slow adsorption kinetics characterized by average adsorption times of at least 168 h.

关键词： Activated Carbon Carbamazepine Sildenafil Citrate methylparaben Adsorption

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