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Meta-analysis of 5, 10-methylenetetrahydrofolate reductase gene polymorphism as a risk factor for ischemic cerebrovascular disease in a Chinese Han population

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Neural Regeneration Research 2011年第5期6卷 360-365页

作者： Hua Bai Department of Neurology First Affiliated Hospital of Chengdu Medical College Chengdu 610500 Sichuan Province China

OBJECTIVE： To assess whether 5, 10-methylenetetrahydrofolate reductase （MTHFR） gene polymorphism （TT genotype or T allele） is a risk factor for ischemic cerebrovascular disease （ICVD）. DATA SOURCES： MEDLINE and PubMed databases from September 1997 to December 2009 were searched for case-control studies that examined MTHFR genotype in human ICVD using ＂MTHFR, gene, polymorphism, and ischemic cerebrovascular disease＂ as search key words. STUDY SELECTION： Eighteen associated studies were identified. The methods used to collect relevant information factors were similar between case and control groups, and diagnosis of ischemic cerebrovascular disease was in accordance with Trial of ORG 10172 in Acute Stroke Treatment criteria classification, with some referring to European Stroke Diagnostic Criteria. Quality of all included studies was evaluated, and meta-analysis was conducted using RevMan4.2 software （Cochrane Collaboration, http：//***） following strict screening. MAIN OUTCOME MEASURES： The correlation between MTHFR gene TT genotype or T allele and ICVD was determined. RESULTS： Eighteen studies involving 4 295 patients with ICVD and 6 169 control subjects were included for this meta-analysis. There was a significant difference in MTHFR gene TT genotype or T allele frequency （x^2 = 15.737, 9.186, P 〈 0.01） between ICVD cases and controls. In addition, six Chinese Han population studies were specially reviewed by meta-analysis. Results showed no significant difference between ICVD and control groups with regard to frequency of MTHFR gene TT genotype and T allele （x^2 = 1.076, 2.434, P 〉 0.05） in the Chinese Han population. CONCLUSION： Results from the present meta-analysis suggested that the MTHFR gene TT genotype or T allele is a risk factor for ICVD. However, the TT genotype or T allele is not a risk factor for ICVD in the Chinese Han population.

关键词： ischemic cerebrovascular disease methylenetetrahydrofolate gene polymorphism

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Association Between Homocysteine Level and methylenetetrahydrofolate Reductase Gene Polymorphisms in Type 2 Diabetes Accompanied by Dyslipidemia

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Chinese Medical Sciences Journal 2020年第1期35卷 85-91页

作者： Ying Yin Rui Li Xiaoli Li Kunrong Wu Ling Li Yuedong Xu Lin Liao Rui Yang Yan Li School of Pharmaceutical Sciences Shandong First Medical University&Shandong Academy of Medical SciencesTai'anShandong 271000China School of Pharmaceutical Sciences Shandong UniversityJinan 250012China Department of Pharmacy Shandong Provincial Qianfoshan HospitalJinan 250014China Department of Endocrinology Shandong Provincial Qianfoshan HospitalJinan 250014China

Objective To investigate the association between total homocysteine(tHcy)level in plasma and methylenetetrahydrofblate reductase(MTHFR)C677T and A1298C genetic polymorphisms in a Chinese Han nationality population with type 2 diabetes mellitus(T2DM)accompanied by *** This case-control study enrolled T2DM patients with dyslipidemia and without dyslipidemia *** dideoxy-mediated chain-termination method was used to detect the gene polymorphisms of MTHFR C677T and *** tHcy and lipid levels were measured as *** genotype frequency and allele frequency between the dyslipidemia and non-dyslipidemia groups were compared by using Chi-square *** tHcy level ofT2DM patients who carried the different genotypes was compared by Student's t *** Finally,82 T2DM patients with dyslipidemia and 94 ones without dyslipidemia were included in this *** was a significant correlation between tHcy level and MTHFR C677T gene polymorphism inT2DM patients(t=2.27,P=0.02).Moreover,the plasma tHcy level in the dyslipidemia patients who carried MTHFR 677TT genotype was significantly higher than that in those with CT+CC genotype(13.62+6.97 vs.10.95+3.62pmol/L,t=2.2O,P=0.03);while for patients without dyslipidemia,comparison of the tHcy level between those who carried the above two alleles showed no significantly difference(13.34±6.03 vs.12.04±5.09μmol/L,t=1.08,P=0.29).Conclusion MTHFR 677TT genotype might associate with higher tHcy level in T2DM patients with dyslipidemia.

关键词： type 2 diabetes mellitus methylenetetrahydrofolate reductase polymorphism homocysteine hyperlipidemia

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Polymorphisms in methylenetetrahydrofolate reductase gene: Their impact on liver steatosis and fibrosis of chronic hepatitis c patients

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Open Journal of Gastroenterology 2014年第2期4卷 73-80页

作者： Engin Altintas Zuhal Mert Altintas Orhan Sezgin Enver Ucbilek Erdinc Nayir Mehmet Emin Erdal Ayse Polat Gulhan Orekeci Department of Biostatistics Faculty of Medicine University of Mersin Mersin Turkey Department of Medical Biology and Genetic Faculty of Medicine University of Mersin Mersin Turkey Department of Pathology Faculty of Medicine University of Mersin Mersin Turkey Gastroenterology Department Faculty of Medicine University of Mersin Mersin Turkey

Aim & Background: The mechanism of steatosis in Hepatitis C virus infection is multifactorial;therefore, it is complex and unclear. The aim of this study was to investigate the effects of methylentetrahydrofolate reductase (MTHFR) gene polymorphisms on the course of chronic hepatitis C virus infection and the development of steatosis due to hepatitis C virus. Methods: This study included 109 patients with chronic hepatitis C virus infection. Necroinflammatory activity, degrees of fibrosis and steatosis and MTHFR gene polymorphisms were investigated. Polymerase chain reaction-restriction fragment length polymorphism was used to determine MTHFR C677T and A1298C polymorphisms. Results: Fibrosis was correlated with age (r = 0.336, p = 0.002), platelet (r = ?0.448, p < 0.0001), ALT (r = 0.241, p = 0.026), AST (r = 0.361) and GGT (r = 0.224, p = 0.039). Steatosis was only correlated with fibrosis. MTHFR C677T and A1298C polymorphisms did not have a significant effect on the degree of steatosis (p = 0.857, p = 0.202 respectively). There was a relation between MTHFR C677T and the degree of fibrosis but not A1298C (p = 0.014, p = 0.187 respectively). Conclusion: We found that MTHFR C677T polymorphism contributed to the development of fibrosis in patients with chronic hepatitis C virus infection.

关键词： Fibrosis Hepatitis C Gene Polymorphism methylenetetrahydrofolate Reductase Steatosis

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A review of methylenetetrahydrofolate reductase in one-carbon metabolism and psychiatric disorders

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Journal of Translational Neuroscience 2018年第2期3卷 6-12页

作者： Lin Wan Rena Li Beijing Institute for Brain Disorders Capital Medical University Beijing 100069 China National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders Beijing AndingHospital Capital Medical University Beijing 100088 China Center for Hormone Advanced Science and Education Roskamp Institute Sarasota FL 34243 USA

methylenetetrahydrofolate reductase(MTHFR)is a key enzyme for the critical process of one-carbon circulation,which convert5,10-methylenetetrahydrofolate to5-methyltetrahydrofolate and participate in folate and homocysteine conversion correlated to methyl group *** enzyme activity decline depends on the gene *** impacts on the methylation process which is related to psychiatric *** have shown association between MTHFR gene polymorphisms and mental disorders,some of which stratified by folate and cobalamin *** this review,we will summarize the testimony on the relationship between methylation and MTHFR polymorphism as well as the implication on psychiatric diseases by MTHFR mutation.

关键词： methylenetetrahydrofolate reductase(MTHFR) polymorphisms DNA methylation psychiatric disorders folate metabolism

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