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Higher rates of autism and attention deficit/hyperactivity disorder in American children:Are food quality issues impacting epigenetic inheritance?

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World Journal of Clinical Pediatrics 2023年第2期12卷 25-37页

作者： Renee J Dufault Raquel A Crider Richard C Deth Roseanne Schnoll Steven G Gilbert Walter J Lukiw Amanda L Hitt Department of Research Food Ingredient and Health Research InstituteNaalehuHI 96772United States College of Graduate Health Studies A.T.Still UniversityKirksvilleMO 63501United States Department of Pharmaceutical Sciences Nova Southeastern UniversityFort LauderdaleFL 33314United States Department of Health and Nutrition Sciences Brooklyn College of CUNYBrooklynNY 11210United States Department of Research Institute of Neurotoxicology and Neurological DisordersSeattleWA 98105United States LSU Neuroscience Center Louisiana State University Health Sciences CenterNew OrleansLA 70112United States Food Integrity Campaign Government Accountability ProjectColumbiaWA 20006United States Department of Legal Food Ingredient and Health Research InstituteNaalehuHI 96772United States

In the United States,schools offer special education services to children who are diagnosed with a learning or neurodevelopmental disorder and have difficulty meeting their learning *** may play a key role in helping children access special education *** number of children ages 6-21 in the United States receiving special education services increased 10.4%from 2006 to *** receiving special education services under the autism category increased 242%during the same *** demand for special education services for children under the developmental delay and other health impaired categories increased by 184%and 83%*** student enrollment in American schools has remained stable since 2006,the percentage distribution of children receiving special education services nearly tripled for the autism category and quadrupled for the developmental delay category by *** heavy metal residues remain persistent in the American food supply due to food ingredient manufacturing *** clinical trial data indicate heavy metal exposures and poor diet are the primary epigenetic factors responsible for the autism and attention deficit hyperactivity disorder *** heavy metal exposures,especially inorganic mercury and lead may impact gene behavior across *** 2021,the United States Congress found heavy metal residues problematic in the American food supply but took no legislative *** health warning labels on select foods may be the only way to reduce dietary heavy metal exposures and improve child learning across generations.

关键词： Lead exposure Mercury Oxidative stress methylation patterns Epigenetic inheritance Autism

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Identification of biological feature based on high-throughput DNA Methylome

Identification of biological feature based on high-throughpu...

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第五届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会高通量时代的生物信息学与系统生物学

作者： Jianzhong Su Haidan Yan 张岩 College of Bioinformatics Science and Technology Harbin Medical University

DNA methylation is an important epigenetic modification for genomic regulation in higher organisms that plays a crucial role in the progression of development or *** integration and mining of DNA methylome by methylation-specific PCR and genome-wide profiling technology could greatly assist the discovery of novel candidate *** permits systemslevel analysis of genomic methylation patterns associated with gene expression and chromatin structure. A comprehensive tool,CpGMPs,is developed for identification and analysis of unmethylated and methylated regions from bisulfite sequencing data,and to identify conserved and differentially methylated regions of various methylation patterns for paired or multiple samples. CpGMPs accurately identifies and analyzes methylated and unmethylated CpG patterns in genomic regions from bisulfite sequencing data using hotspot *** identifies conserved and differentially methylated regions among multiple samples(cells or tissues) using linear *** methylation patterns of genomic regions are qualitatively and dynamically identified using the methylation status of neighboring CpGs,without knowledge of predefined regions or the average methylation of CpGs in the genomic *** identified the methylation patterns in genomic regions from five human bisulfite sequencing data during cellular *** cell-specific methylation pattern *** potentially functional regions form candidate regions for analysis of the function of DNA methylation during cellular differentiation. CpGPs is the first user-friendly tool for identifying methylation patterns of genomic regions from bisulfite sequencing data,permitting further investigation of the biological functions of genome-scale methylation patterns.

关键词： DNA methylation Bisulfite sequencing methylation patterns Differentially methylated regions

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