检索结果-南通市图书馆

Effect of interaction between loop bases and ions on stability of G-quadruplex DNA

Chinese Physics B 2021年第1期30卷 605-611页

作者：乔汉真吴园燕涂育松祭聪敏 College of Physics Science and Technology Yangzhou UniversityYangzhou 225009China

G-quadruplexes(GQs) are guanine-rich, non-canonical nucleic acid structures that play fundamental roles in biological processes. The topology of GQs is associated with the sequences and lengths of DNA, the types of linking loops, and the associated metal cations. However, our understanding on the basic physical properties of the formation process and the stability of GQs is rather limited. In this work, we employed ab initio, molecular dynamics(MD), and steered MD(SMD)simulations to study the interaction between loop bases and ions, and the effect on the stability of G-quadruplex DNA, the Drude oscillator model was used in MD and SMD simulations as a computationally efficient manner method for modeling electronic polarization in DNA ion solutions. We observed that the binding energy between DNA bases and ions(K^(+)/Na^(+))is about the base stacking free energies indicates that there will be a competition among the binding of M^(+)-base, H-bonds between bases, and the base-stacking while ions were bound in loop of GQs. Our SMD simulations indicated that the side loop inclined to form the base stacking while the loop sequence was Thy or Ade, and the cross-link loop upon the G-tetrads was not easy to form the base stacking. The base stacking side loop complex K+was found to have a good stabilization synergy. Although a stronger interaction was observed to exist between Cyt and K+, such an interaction was unable to promote the stability of the loop with the sequence Cyt.

关键词： G-quadruplex loop DNA base metalion

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Solute carrier transporters: the metabolic gatekeepers of immune cells

引用

Acta Pharmaceutica Sinica B 2020年第1期10卷 61-78页

作者： Wenxin Song Danyuan Li Lei Tao Qi Luo Ligong Chen School of Pharmaceutical Sciences Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology(Ministry of Education)Tsinghua UniversityBeijing 100084China Advanced Innovation Center for Human Brain Protection Capital Medical UniversityBeijing 100088China Collaborative Innovation Center for Biotherapy State Key Laboratory of Biotherapy and Cancer CenterWest China HospitalWest China Medical SchoolSichuan UniversityChengdu 610065China

Solute carrier(SLC)transporters meditate many essential physiological functions,including nutrient uptake,ion influx/efflux,and waste *** its protective role against tumors and infections,the mammalian immune system coordinates complex signals to support the proliferation,differentiation,and effector function of individual cell *** research in this area has yielded surprisingfindings on the roles of solute carrier transporters,which were discovered to regulate lymphocyte signaling and control their differentiation,function,and fate by modulating diverse metabolic pathways and balanced levels of different *** this review,we present current information mainly on glucose transporters,amino-acid transporters,and metal ion transporters,which are critically important for mediating immune cell homeostasis in many different pathological conditions.

关键词： Solute carrier Lymphocytes Glucose Glutamine metalion

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of humic acid and metal ions on the debromination of BDE209 by nZVM prepared from steel pickling waste liquor

引用

Frontiers of Environmental Science & Engineering 2015年第5期9卷 879-887页

作者： Yuling CAI School of Chemistry and Environment South China Normal University Guangzhou 510006 China Guangdong Technology Research Centre for Ecological Management and Remediation of Urban Water System Guangzhou 510006 China Department of Science and Environmental Studies Hong Kong Institute of Education Hong Kong 00852 China

As a promising in situ remediation technology, nanoscale zero-valent iron （nZVI） can remove polybromi- nated diphenyl ethers such as decabromodiphenyl ether （BDE209） effectively, However its use is limited by its high production cost. Using steel pickling waste liquor as a raw material to prepare nanoscale zero-valent metal （nZVM） can overcome this deficiency. It has been shown that humic acid and metal ions have the greatest influence on remediation. The results showed that nZVM and nZVI both can effectively remove BDE209 with little difference in their removal efficiencies, and humic acid inhibited the removal efficiency, whereas metal ions promoted it. The promoting effects followed the order Ni2＋〉 Cu2＋〉 Co2＋ and the cumulative effect of the two factors was a combination of the promoting and inhibitory individual effects. The major difference between nZVM and nZVI lies in their crystal form, as nZVI was found to be amorphous while that of nZVM was crystal. However, it was found that both nZVM and nZVI removed BDE209 with similar removal efficiencies. The effects and cumu- lative effects of humic acid and metal ions on nZVM and nZVI were very similar in terms of the efficiency of the BDE209 removal.

关键词： steel pickling waste liquor nanoscale zero-valet metal nanoscale zerovalent iron humic acid metalion

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：