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metal-based nanoparticles for cardiovascular disease diagnosis and therapy

Particuology 2023年第1期72卷 94-111页

作者： Lei Li Yun Zeng Gang Liu State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics Center for Molecular Imaging and Translational MedicineSchool of Public HealthXiamen UniversityXiamen 361102China Department of Pharmacy Xiamen Medical CollegeXiamen 361023China

Cardiovascular diseases (CVDs) are the most prominent cause of disability and mortality in the world. Although there have been a variety of therapeutic options for the management of CVDs, most of the traditional therapeutic strategies could not sufficiently stop or reduce the progression of these diseases and may result in some side effects. With the advance in nanotechnology, a number of metal-based nanoparticles have been developed and shown promising potentials in the treatment of CVDs. In this review, we provide a comprehensive review of researches on recent development of metal-based nanoparticles in diagnosis and therapy in CVDs as biomedical materials. We also discuss the challenges in the clinical translation and potential risks in their application of CVD therapy. based on the ongoing research and applications, we can conclude metal-based nanoparticles are expected to become potential therapeutics for the treatment of CVDs. But their application is still in its infancy and much more efforts should be made to enforce a clinical breakthrough.

关键词： metal-based nanoparticles Nanomedicine Cardiovascular diseases Diagnosis Therapy

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Self-therapeutic metal-based nanoparticles for treating inflammatory diseases

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Acta Pharmaceutica Sinica B 2023年第5期13卷 1847-1865页

作者： Ruifang Han Yu Xiao Qianqian Bai Chung Hang Jonathan Choi Department of Biomedical Engineering the Chinese University of Hong KongShatinNew TerritoriesHong Kong SARChina

Inflammatory diseases are key contributors to high mortality globally and adversely affect the quality of *** treatments include corticosteroids or nonsteroidal anti-inflammatories that may cause systemic toxicity and biologics that may increase the risk of *** nanoparticles that bear not only the drug payload but also targeting ligands for delivery to inflammation sites at lowered systemic toxicity are established in the nanomedicine field,but their relatively large size often leads to systemic ***-based nanoparticles with intrinsic anti-inflammatory properties represent attractive *** are not only designed to be compact for crossing biological barriers(with the nanoparticle serving as a dual carrier and drug),but also support label-free tracking of their interactions with *** review commences with an outline of the common inflammatory diseases,inflammatory pathways involved,and conventional drug-loaded nanoparticles for ***,the review features the emerging applications of self-therapeutic metal-based nanoparticles(e.g.,gold,coper oxide,platinum,ceria,and zinc oxide)for managing inflammatory diseases in animals over the past three years,focusing on therapeutic outcomes and anti-inflammatory *** review concludes with an outlook on the biodistribution,long-term toxicity,and clinical translation of self-therapeutic metalbased nanoparticles.

关键词： metal-based nanoparticles Inflammatory disease Self-therapeutic Nanomedicine Delivery Gold nanoparticles Clinical translation Reactive oxygen species

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