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Design,fabrication,and structural safety validation of 3D-printable biporous bone augments

Bio-Design and Manufacturing 2023年第1期6卷 26-37页

作者： Yeokyung Kang Dasol Lim Doo-Hoon Sun Jong-Chul Park Jungsung Kim Central Research&Development Center Corentec Company Ltd.33-2Banpo-daero 20-gilSeocho-guSeoulRepublic of Korea Cellbiocontrol Laboratory Department of Medical EngineeringYonsei University College of Medicine50-1 Yonsei-roSinchon-dongSeodaemun-guSeoulRepublic of Korea Department of Orthopaedic Surgery Daejeon Sun Hospital10-7 Mok-dongJung-guDaejeonRepublic of Korea

The use of commercial products such as a cup and liner for total hip arthroplasty for patients with severe bone defects has a high probability of *** these patients the cup alone cannot cover the bone defect,and thus,an additional augment or cage is *** this study,we designed three-dimensional(3D)printable bone augments as an alternative to surgeries using reinforcement ***-five sharp-edged bone augments of various sizes were 3D printed.A biporous structure was designed to reduce the weight of the augment and to facilitate bone *** types of frames were used to prevent damage to the augment’s porous structure and maintain its stability during ***,two types of holes were provided for easy augment fixation at various *** tests were performed on a combination of worst-case sizes derived using finite element *** test results confirmed the structural stability of the specimens at a load of 5340 *** the porosity of the specimens was measured to be 63.70%,it cannot be said that the porous nature was uniformly distributed because porosity tests were performed locally and *** summary,3D-printable biporous bone augments capable of bonding from various angles and bidirectionally through angulation and bottom-plane screw holes are *** mechanical results with bone augments indicate good structural safety in ***,further research is necessary to study the clinical applications of the proposed bone augment.

关键词： Bone augment 3D printing Biporous structure Total hip arthroplasty metal implant

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Additively manufactured metallic biomaterials

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Bioactive Materials 2022年第9期7卷 214-249页

作者： Elham Davoodi Hossein Montazerian Anooshe Sadat Mirhakimi Masoud Zhianmanesh Osezua Ibhadode Shahriar Imani Shahabad Reza Esmaeilizadeh Einollah Sarikhani Sahar Toorandaz Shima ASarabi Rohollah Nasiri Yangzhi Zhu Javad Kadkhodapour Bingbing Li Ali Khademhosseini Ehsan Toyserkan Multi-Scale Additive Manufacturing(MSAM)Laboratory Mechanical and Mechatronics Engineering DepartmentUniversity of WaterlooWaterlooOntario N2L 3G1Canada Department of Bioengineering University of CaliforniaLos AngelesCalifornia 90095United States California NanoSystems Institute(CNSI) University of CaliforniaLos AngelesCalifornia 90095United States Terasaki Institute for Biomedical Innovation Los AngelesCalifornia 90024United States Department of Mechanical Engineering Isfahan University of TechnologyIsfahanIsfahan 84156-83111Iran School of Biomedical Engineering University of SydneySydneyNew South Wales 2006Australia Department of Nanoengineering Jacobs School of EngineeringUniversity of CaliforniaSan DiegoCalifornia 92093United States Mechanical and Aerospace Engineering Department University of CaliforniaLos AngelesCalifornia 90095United States Department of Mechanical Engineering Shahid Rajaee Teacher Training UniversityTehranTehran 16785-163Iran Institute for Materials Testing Materials Science and Strength of MaterialsUniversity of StuttgartStuttgart 70569Germany Department of Manufacturing Systems Engineering and Management California State UniversityNorthridgeCalifornia 91330United States

metal additive manufacturing(AM)has led to an evolution in the design and fabrication of hard tissue substitutes,enabling personalized implants to address each patient’s specific *** addition,internal pore architectures integrated within additively manufactured scaffolds,have provided an opportunity to further develop and engineer functional implants for better tissue integration,and long-term *** this review,the latest advances in different aspects of the design and manufacturing of additively manufactured metallic biomaterials are *** introducing metal AM processes,biocompatible metals adapted for integration with AM machines are ***,we elaborate on the tools and approaches undertaken for the design of porous scaffold with engineered internal architecture including,topology optimization techniques,as well as unit cell patterns based on lattice networks,and triply periodic minimal ***,the new possibilities brought by the functionally gradient porous structures to meet the conflicting scaffold design requirements are thoroughly ***,the design constraints and physical characteristics of the additively manufactured constructs are reviewed in terms of input parameters such as design features and AM processing *** assess the proposed applications of additively manufactured implants for regeneration of different tissue types and the efforts made towards their clinical ***,we conclude the review with the emerging directions and perspectives for further development of AM in the medical industry.

关键词： Additive manufacturing metal implant Porous scaffold Tissue engineering Biomaterials

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