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metal nanoparticles for cancer therapy:Precision targeting of DNA damage

Acta Pharmaceutica Sinica B 2024年第3期14卷 1132-1149页

作者： Qian Chen Chunyan Fang Fan Xia Qiyue Wang Fangyuan Li Daishun Ling Institute of Pharmaceutics Hangzhou Institute of Innovative MedicineCollege of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Frontiers Science Center for Transformative Molecules School of Chemistry and Chemical EngineeringNational Center for Translational MedicineShanghai Jiao Tong UniversityShanghai 200240China World Laureates Association(WLA)Laboratories Shanghai 201203China Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province Hangzhou 310009China

Cancer,a complex and heterogeneous disease,arises from genomic ***,DNA damage-based cancer treatments,including radiotherapy and chemotherapy,are employed in clinical ***,the efficacy and safety of these therapies are constrained by various factors,limiting their ability to meet current clinical *** nanoparticles present promising avenues for enhancing each critical aspect of DNA damage-based cancer *** customizable physicochemical properties enable the development of targeted and personalized treatment *** this review,we delve into the design principles and optimization strategies of metal *** shed light on the limitations of DNA damage-based therapy while highlighting the diverse strategies made possible by metal *** encompass targeted drug delivery,inhibition of DNA repair mechanisms,induction of cell death,and the cascading immune ***,we explore the pivotal role of physicochemical factors such as nanoparticle size,stimuli-responsiveness,and surface modification in shaping metal nanoparticle ***,we present insights into the challenges and future directions of metal nanoparticles in advancing DNA damage-based cancer therapy,paving the way for novel treatment paradigms.

关键词： DNA damage metal nanoparticles Nucleus-targeting DNA repair inhibition Immune response Size optimization Stimuli-responsiveness Surface modification

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Quasi-MOF-immobilized metal nanoparticles for synergistic catalysis

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Science China Chemistry 2020年第11期63卷 1601-1607页

作者： Liyu Chen Nobuko Tsumori Qiang Xu AIST-Kyoto University Chemical Energy Materials Open Innovation Laboratory(ChEM-OIL) National Institute of Advanced Industrial Science and Technology(AIST)YoshidaSakyo-kuKyoto 606-8501Japan Toyama National College of Technology 13 Hongo-machiToyama 939-8630Japan School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225002China

Through partial deligandation of metal-organic frameworks(MOFs),quasi-MOFs with a transition structure between MOFs and metal compounds(such as metal oxides,nitrides,sulfides,and phosphides)can be ***-MOFs can not only retain the porous structure of MOFs to a certain extent,but also expose the inorganic nodes to the guest species(e.g.,metal nanoparticles)to show enhanced metal-support interaction for synergistic *** concept was first demonstrated by our group through calcining Au/MIL-101 at different temperatures under Ar flow to adjust the interface between Au nanoparticles and the inorganic Cr–O *** obtained Au/quasi-MIL-101 showed superior enhanced catalytic activity in the oxidation of carbon *** study has inspired further research interest to fabricate other quasi-MOFs through controlled deligandation of mono-and bimetallic MOFs and their composites for the design of efficient catalysts.

关键词： MOFs metal nanoparticles metal-support interaction quasi-MOFs synergistic catalysis

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pH-responsive metal nanoparticles as high contrast theranostic agents for selective imaging and synergistic cancer therapy

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Science China Chemistry 2024年第9期67卷 3063-3070页

作者： Sichao Tian Xiaofeng He Xiao Wu Dongxue Hu Qing-Hua Xu Department of Chemistry National University of SingaporeSingapore 117543Singapore National University of Singapore(Suzhou)Research Institute Suzhou 215123China Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China Department of Biological Sciences Faculty of ScienceNational University of SingaporeSingapore 117558Singapore

The low signal-to-noise ratio(S/N)and single functionality of fluorescence imaging agents have limited their practical *** two-photon excitation(2PE)imaging probes are highly desirable in vivo with larger imaging depth,minor autofluorescence background,and less ***,we developed responsive aggregated gold nanoparticles(Au NPs)as high contrast 2PE imaging agents,capable of emitting red fluorescence upon excitation of near-infrared(NIR)laser and possessing a high signal-to-noise ratio(S/N of 2,475).By forming aggregates in situ inside tumor tissue,doxorubicin hydrochloride(DOX)-loaded mix-charged gold nanoparticles(DOX-MC-Au NPs)were utilized to act as selective fluorescence imaging probes and precise therapy *** high-contrast theranostic agents offer a promising potential for precise cancer imaging and therapy,which might open a new venue to multifunctional and noninvasive theranostics.

关键词： metal nanoparticles two-photon excitation high contrast imaging agents fluorescence imaging cancer therapy

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Well-defined high entropy-metal nanoparticles:Detection of the multi-element particles by deep learning

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Journal of Energy Chemistry 2024年第11期98卷 262-273页

作者： Manar Alnaasan Wail Al Zoubi Salh Alhammadi Jee-Hyun Kang Sungho Kim Young Gun Ko Department of Electronics Engineering Yeungnam Univeristy280 Daeha-roGyeongsan38541Republic of Korea Materials Electrochemistry Laboratory School of Materials Science and EngineeringYeungnam UniversityGyeongsan 38541Republic of Korea Department of Future Energy Convergence Seoul National University of Science and Technology232 Gongneung-RoNowon-GuSeoul 01811Republic of Korea School of Materials Science and Engineering Institute of Materials TechnologyYeungnam UniversityGyeongsan 38541Republic of Korea

Characterizing and control the chemical compositions of multi-element particles as single metal nanoparticles(mNPs) on the surfaces of catalytic metal oxide supports is *** can be attributed to the heterogeneity and large size at the nanoscale,the poorly defined catalyst nanostructure,and thermodynamic immiscibility of the strongly repelling metallic *** address these challenges,an ultrasonic-assisted coincident electro-oxidation-reduction-precipitation(U-SEO-P) is presented to fabricate ultra-stable PtRuAgCoCuP NPs,which produces numerous active intermediates and induces strong metal-support *** sort the active high-entropy mNPs,individual NPs are described on the support surface and the role of deep learning in understanding/predicting the features of PtRuAgCoCu@TiO_(x) catalysts is ***,this deep learning approach required minimal to no human *** as-prepared PtRuAgCoCu@TiO_(x) catalysts can be used to catalyze various important chemical reactions,such as a high reduction conversion(100% in 30 s),with no loss of catalytic activity even after 20 cycles of nitroarene and ketone/aldehyde,which is several times higher than commercial Pt@TiO_(x) owing to individual PtRuAgCoCuP NPs on TiO_(x) *** this study,we present the "Totally Defined Catalysis" concept,which has enormous potential for the advancement of high-activity catalysts in the reduction of organic compounds.

关键词： metal nanoparticles Deep learning Catalyst Reduction

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Rapid room-temperature synthesis of a porphyrinic MOF for encapsulating metal nanoparticles

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Nano Research 2021年第2期14卷 444-449页

作者： Huihui He Luyan Li Yang Liu Meruyert Kassymova Dandan Li Liangliang Zhang Hai-Long Jiang Frontiers Science Center for Flexible Electronics(FSCFE) Shaanxi Institute of Flexible Electronics(SIFE)&Shaanxi Institute of Biomedical Materials and Engineering(SIBME)Northwestern Poly technical University(NPU)Xi’an 710072China Institutes of Physics Science and Information Technology Anhui UniversityHefei 230601China Hefei National Laboratory for Physical Sciences at the Microscale Department of ChemistryUniversity of Science and Technology of ChinaHefei 230026China

While metal nanoparticles(NPs)have shown great promising applications as heterogeneous catalysts,their agglomeration caused by thermodynamic instability is detrimental to the catalytic *** tackle this hurdle,we successfully prepared a functional and stable porphyrinic metal-organic framework(MOF),PCN-224-RT,as a host for encapsulating metal nanoparticles by direct stirring at room *** a result,Pt@PCN-224-RT composites with well-dispersed Pt NPs can be constructed by introducing pre-synthesized Pt NPs into the precursor solution of *** note,the rapid and simple stirring method in this work is more in line with the requirements of environmental friendly and industrialization compared with traditional solvothermal methods.

关键词： metal nanoparticles room tem perature and rapid synthesis PCN-224 Ostwald ripening

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Second harmonic generation of metal nanoparticles under tightly focused illumination

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Chinese Physics B 2016年第3期25卷 403-407页

作者：孙经纬王湘晖常胜江曾明张娜 Institute of Modern Optics Optical Information Science and Technology Key Laboratory of the Ministry of EducationNankai UniversityTianjin 300071China School of Electrical Engineering and Automation Tianjin UniversityTianjin 300072China

The near-field and far-field second harmonic （SH） responses of a metal spherical nanoparticle placed in the focal region of a highly focused beam are investigated by using the calculation model based on three-dimensional finite-difference time-domain （FDTD） method. The results show that off-axis backward-propagating SH response can be reinforced by tightly focusing, due to the increase of the relative magnitude of the longitudinal field component and the phase shift along the propagation direction.

关键词： second harmonic generation metal nanoparticles focused field

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Spatial compartmentalization of metal nanoparticles within metal-organic frameworks for tandem reaction

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Nano Research 2022年第2期15卷 1178-1182页

作者： Ting Pan Islam E.Khalil Zhiling Xu Hongfeng Li Xinglong Zhang Gengwu Xiao Weina Zhang Yu Shen Fengwei Huo Key Laboratory of Flexible Electronics(KLOFE)and Institute of Advanced Materials(IAM) Nanjing Tech UniversityNanjing 211816China

Fabrication of multifunctional catalysts has always been the pursuit of synthetic chemists due to their efficiency,cost-effectiveness,and environmental ***,it is difficult to control multi-step reactions in one-pot,especially the spatial compartmentalization of incompatible active ***,we constructed metal-organic framework(MOF)composites which regulate the location distribution of metal nanoparticles according to the reaction path and coupled with the diffusion of substrates to achieve tandem *** designed UiO-66-Pt-Au catalyst showed good activity and selectivity in hydrosilylation-hydrogenation tandem reaction,because the uniform microporous structures can control the diffusion path of reactants and intermediates,and Pt and Au nanoparticles were arranged in core-shell spatial distribution in *** contrast,the low selectivity of catalysts with random deposition and physical mixture demonstrated the significance of artificial control to the spatial compartmentalization of active sites in tandem catalytic reactions,which provides a powerful approach for designing high-performance and multifunctional heterogeneous catalysts.

关键词： metal-organic frameworks metal nanoparticles spatial compartmentalization tandem reaction heterogeneous catalysis

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Catalytic activity of noble metal nanoparticles toward hydrodechlorination： influence of catalyst electronic structure and nature of adsorption

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Frontiers of Environmental Science & Engineering 2015年第5期9卷 888-896页

作者： Man ZHANG Feng HE Dongye ZHAO Department of Civil Engineering Auburn University Auburn AL 36849 USA College of Biological and Environmental Engineering Zhejiang University of Technology Hangzhou 310014 China

In this study, stabilized Pd, Pt and Au nanoparticles were successfully prepared in aqueous phase using sodium carboxymethyl cellulose （CMC） as a capping agent. These metal nanoparticles were then tested for catalytic hydrodechlorination toward two classes of organochlorinated compounds （vinyl polychlorides includ- ing trichloroethylene （TCE）, tetrachloroethylene （PCE）, and alkyl polychlorides including 1,1,1-trichloroethane （1,1,1-TCA）, and 1,1,1,2-tetrachloroethane （1,1,1,2- TeCA）） to determine the rate-limiting steps and to explore the reaction mechanisms. The surface area normalized reaction rate constant, ksA, showed a systematic depen- dence on the electronic structure （the density of states at the Fermi level） of the metals, suggesting that adsorption of organochlorinated reactants on the metal catalyst surfaces is the rate-limiting step for catalytic hydrodechlorination. Hydrodechlorination rates of 1,1,1-TCA and 1,1,1,2-TeCA agreed with the bond strength of the first （weakest） dissociated C-C1 bond, suggesting that C-C1 bond cleavage, which is the first step for dissociative adsorption of the alkyl polychlorides, controlled the catalytic hydro- dechlorination rate. However, hydrodechlorination rates of TCE and PCE correlated with the adsorption energies of their molecular （non-dissociative） adsorption on the noble metals rather than with the first C-C1 bond strength, suggesting that molecular adsorption governs the reaction rate for hydrodechlorination of the vinyl polychlorides.

关键词： catalytic hydrodechlorination electronicstructure metal nanoparticles reaction mechanisms

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Sweet plasmonics： Sucrose macrocrystals of metal nanoparticles

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Nano Research 2015年第3期8卷 860-869页

作者： Talha Erdem Zeliha Soran-Erdem Pedro Ludwig Hernandez-Martinez Vijay Kumar Sharma Halil Akcali Ibrahim Akcali Nikolai Gaponik Alexander Eychmeller Hilmi Volkan Demir Departments of Electrical and Electronics Engineering Physics UNAM-National Nanotechnology Research Center and Institute ot Materials Science and Nanotechnology Bilkent University Ankara 06800 Turkey School of Electrical and Electronic Engineering and School of Physical and Mathematical Sciences Nanyang Technological University Singapore 639798 Singapore Physical Chemistry TU Dresden Bergstrasse 66b D-O 1062 Dresden Germany

The realization of plasmonic structures generally necessitates expensive fabrication techniques, such as electron beam and focused ion beam lithography, allowing for the top-down fabrication of low-dimensional structures. Another approach to make plasmonic structures in a bottom-up fashion is colloidal synthesis, which is convenient for liquid-state applications or very thin solid films where aggregation problems are an important challenge. The architectures prepared using these methods are typically not robust enough for easy handling and convenient integration. Therefore, developing a new plasmonic robust platform having large-scale dimensions without adversely affecting the plasmonic features is in high demand. As a solution, here we present a new plasmonic composite structure consisting of gold nanoparticles （Au NPs） incorporated into sucrose macrocrystals on a large scale, while preserving the plasmonic nature of the Au NPs and providing robustness in handling at the same time. As a proof of concept demonstration, we present the fluorescence enhancement of green CdTe quantum dots （QDs） via plasmonic coupling with these Au NPs in the sucrose crystals. The obtained composite material exhibits centimeter scale dimensions and the resulting quantum efficiency （QE） is enhanced via the interplay between the Au NPs and CdTe QDs by 58% （from 24% to 38%）. Moreover, a shortening in the photoluminescence lifetime from 11.0 to 7.40 ns, which corresponds to a field enhancement factor of 2.4, is observed upon the introduction of Au NPs into the QD incorporated macrocrystals. These results suggest that such ＂sweet＂ plasmonic crystals are promising for large-scale robust platforms to embed plasmonic nanoparticles.

关键词： plasmonics macrocrystals metal nanoparticles metal enhancedfluorescence colloidal quantum dots

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Insight into Lithium–sulfur batteries performance enhancement:from metal nanoparticles to metal nanoclusters to single metal atoms

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Tungsten 2024年第3期6卷 504-521页

作者： Shuang Ma Qing-Ling Ruan Xue-Cheng Liu Gui-Jun Zhu Die Yuan Ling-Qiao Hu Yu-Mei Huang Xing-Xing Gu Chongqing Key Laboratory of Catalysis and New Environmental Materials College of Environment and ResourcesChongqing Technology and Business UniversityChongqing 400067China National Research Base of Intelligent Manufacturing Service Chongqing Technology and Business UniversityChongqing 400067China

Lithium-sulfur(Li-S)batteries have attracted much attention and developed rapidly in recent years due to their high energy density,low cost,and ***,its commercialization process still encounters various *** them,the sulfur cathode is easy to dissolve and shuttle,resulting in the loss of active substances and the severe growth of lithium anode dendrites,which is one of the biggest *** the redox conversion kinetics of sulfur cathode is expected to fundamentally alleviate the shuttle phenomenon of poly ***,this paper reviews the effects of metal nanoparticles to metal nanoclusters to metal single-atom catalysts on improving the redox of Li-S batteries,to let researchers better understand the size effect on the kinetics of sulfur cathodes in Li-S batteries,which will provide important guidance for the future large-scale commercialization of Li-S batteries.

关键词： Lithium–sulfur batteries metal nanoparticles metal nanoclusters metal single atoms Size effects

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