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Overlapping infections of Mycobacterium canariasense and Nocardia farcinica in an immunocompetent patient:A case report

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World Journal of Clinical Cases 2024年第12期12卷 2079-2085页

作者： Hai-Yan Huang Kun-Peng Bu Jin-Wei Liu Jing Wei Department of Comprehensive Internal Medicine The Affiliated Cancer Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Doppler Ultrasound The Second Nanning People's HospitalNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Infections by non-tuberculous mycobacteria(NTM)have become more common in recent *** canariasense(***)was first reported as an opportunistic pathogen in 2004,but there have been very few case reports since *** is a genus of aerobic and Gram-positive bacilli,and these species are also opportunistic pathogens and in the Mycobacteriales *** methods for diagnosis of NTM are *** next-generation sequencing(mNGS)can rapidly detect many pathogenic microorganisms,even rare *** NTM and Nocardia infections occur in immunocompromised patients with atypical clinical *** are no previous reports of infection by *** and Nocardia farcinica(***),especially in immunocompetent *** case report describes an immunocompetent 52-year-old woman who had overlapping infections of ***,***,and Candida parapsilosis(***)based on *** SUMMARY A 52-year-old woman presented with a productive cough and chest pain for 2 wk,and recurrent episodes of moderate-grade fever for 1 *** received antibiotics for 1 wk at a local hospital,and experienced defervescence,but the productive cough and chest pain *** collected samples of a lung lesion and alveolar lavage fluid for *** lung tissue was positive for ***,***,and ***,and the alveolar lavage fluid was positive for *** diagnosis was pneumonia,and application of appropriate antibiotic therapy cured the *** Etiological diagnosis is critical for patients with infectious *** can identify rare and novel pathogens,and does not require a priori knowledge.

关键词： Overlapping infection Mycobacterium canariasense Nocardia farcinica metagenomic next-generation sequencing technology Case report

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