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Serum Metabolomic Indicates Potential Biomarkers and Metabolic pathways of Pediatric Kashin-Beck Disease

Biomedical and Environmental Sciences 2020年第10期33卷 750-759页

作者： WANG Yu Meng WANG Wei Yi SUN Li Yan LI Qiang ZHAO Zhi Jun HU Jian ZHANG Rong Yu WANG Li Hua Center for Endemic Disease Control Chinese Center for Disease Control and PreventionHarbin Medical University/Key Lab of Etiology and EpidemiologyEducation Bureau of Heilongjiang Province&Ministry of HealthHarbin 150081Heilongjiang China Qinghai Institute for Endemic Disease prevention and Control Xining 811602QinghaiChina

Objective To explore potential serum biomarkers of children with Kashin-Beck Disease(KBD)and the metabolic pathways to which the biomarkers *** A two-stage metabolomic study was *** discovery cohort included 56 patients,51 internal controls,and 50 external *** metabolites were determined by HPLC-(Q-TOF)-MS and confirmed by Human Metabolome Databases(HMDB)and Metlin *** 3.0 and the Kyoto Encyclopedia of Genes and Genomes(KEGG)database were used to analyze the metabolic pathways of the candidate *** use of HPLC-(Q-TRAP)-MS enabled quantitative detection of the target metabolites which were chosen using the discovery study and verified in another independent verification cohort of 31 patients,41 internal controls,and 50 external *** Eight candidate metabolites were identified out in the discovery study,namely kynurenic acid,N-α-acetylarginine,6-hydroxymelatonin,sphinganine,ceramide,sphingosine-1 P,spermidine,and *** metabolites exist in sphingolipid,glutathione,and tryptophan metabolic *** the second-stage study,five candidate metabolites were validated,including kynurenic acid,N-α-acetylarginine,sphinganine,spermidine,and sphingosine-1 *** for spermidine,all substances exhibited low expression in the case group compared with the external control group,and the difference in levels of sphinganine,spermidine,and sphingosine-1 P was statistically *** The direction of change of levels of sphinganine,spermidine,and sphingosine-1 P in the two-stage study cohorts was completely consistent,and the differences were statistically ***,these substances can be used as potential biomarkers of ***,these results raise the possibility that sphingolipid metabolic pathways may be closely related to KBD.

关键词： Kashin-Beck disease Potential biomarkers metabolism pathways Serum

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Impact of Bifidobacterium longum NSP001 on DSS-induced colitis in conventional and humanised mice

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Food Science and Human Wellness 2023年第4期12卷 1109-1118页

作者： Menglin Chen Hong Yao Huizi Tan Wenqi Huang Quanyong Wu Shaoping Nie State Key Laboratory of Food Science and Technology China-Canada Joint Laboratory of Food Science and Technology(Nanchang)Nanchang UniversityNanchang 330047China

Most scientific investigations regarding inflammatory bowel disease(IBD)pathogenesis or therapeutic strategies use dextran sulfate sodium(DSS)-induced models performed on ***,differences between human and animal microbiota may confound the data reproducibility from rodent experiments to clinical *** this study,the intervention effects of Bifidobacterium longum NSP001 on DSS-induced colitis were investigated using mice colonized with either native or humanised *** in disease activity index(DAI),morphology and histology of colon tissue,intestinal permeability,and secretion of MPO,TNF-αand IL-6 were ameliorated by daily intake of live *** NSP001 cells in both conventional and humanised colitis *** the abnormal thymus index,and colonic production of ZO-1 and iNOS were improved only in colitis mice treated with *** NSP001 and humanised *** accumulation of acetic acid and propionic acid in colon microbiome,and the optimization of primary bile acid biosynthesis and glycerophospholipid metabolism pathways in cecum commensals were likely to explain the beneficial effects of *** *** data revealed that intestinal microbiome baseline would possibly affect the manifestation features of interventions by probiotics or dietary components and highlighted the necessity to include humanised microbiome while investigating potential therapeutic strategies based on rodent models.

关键词： Bifidobacterium longum Ulcerative colitis Humanised mice Inflammation metabolism pathways

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Genome-Wide identification of Zn（2）-Cys（6）class fungal-specific transcription factors（ZnFTFs）and functional analysis of UvZnFTF1 in Ustilaginoidea virens

Genome-Wide identification of Zn（2）-Cys（6）class fungal-s...

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中国植物病理学会2021年学术年会

作者： SONG Tianqiao ZHANG Xiong ZHANG You LIANG Dong YAN Jiaoling YU Junjie YU Mina CAO Huijuan YONG Mingli PAN Xiayan QI Zhongqiang DU Yan ZHANG Rongsheng LIU Yongfeng Institute of Plant Protection Jiangsu Academy of Agricultural Sciences School of Life Sciences Jiangsu University Key Laboratory of Biology and Genetic Improvement of Oil Crops Ministry of Agriculture and Rural Affairs/Oil Crops Research InstituteChinese Academy of Agricultural Sciences School of the Environment and Safety Engineering Jiangsu University

Transcription factors（TFs） orchestrate the regulation of cellular gene expression and thereby determine cell *** fungi,TFs play essential roles in cellular functions,but systematic analyses of these TFs are *** this study,we analyzed the distribution of TFs(ontaining both domains,which we named ZnFTFs,in ascomycete and basidiomycete *** found that ZnFTFs were widely distributed in these fungal species,but there was more expansion of the ZnFTF class in Ascomycota than in *** identified 40 ZnFTFs in Ustilaginoidea virens,a pathogen causing rice false smut disease,and demonstrated the involvement of UvZnFTFl in vegetative growth,conidiation,pigment biosynthesis,and ***-seq analysis suggested that UvZnFTFl might regulate different nutrient metabolism pathways,the production of secondary metabolites and the expression of PHI（pathogen-host interaction） genes and secreted protein-encoding *** of the distribution of different fungal TFs in *** further demonstrated that UvZnFTFs made up a large TF family and might play essential biological roles in ***.

关键词： Zn(2)Cys(6)-type fungal-specific transcription factor Ustilaginoidea virens rice pathogen gene silencing RNA-seq metabolism pathways effector expression pathogenhost interaction

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