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Lipid-lowering effect of microencapsulated peptides from brewer’s spent grain in high-sucrose diet-fed rats

Food Bioscience 2022年第5期49卷 981-989页

作者： M.R.Ferreira A.G.Garz´on M.E.Oliva R.E.Cian S.R.Drago M.E.D’Alessandro Laboratorio de Estudio de Enfermedades Metab´olicas Relacionadas con la Nutrici´on Facultad de Bioquímica y Ciencias Biol´ogicasUniversidad Nacional del LitoralCiudad UniversitariaSanta FeArgentina Instituto de Tecnología de Alimentos Facultad de Ingeniería QuímicaUniversidad Nacional del Litoral1ro de Mayo3250Santa FeArgentina Consejo Nacional de Investigaciones Científicas y T´ecnicas(CONICET) Argentina

Brewer’s spent grain(BSG)-a byproduct generated from the processing of beer-brewing industry-is currently recognized as an important source of bioactive peptides with potential health *** previous studies we demonstrated that peptides obtained from BSG(BSG-P)can exert in vitro biofunctional activities including hypolipidemic ***,there are no studies about the effects of gastrointestinal digestion on BSG lipid-lowering peptides and it is unknown whether the bioactive properties observed in vitro remain in *** aims of this work were to evaluate the microencapsulation as strategy to preserve hypolipidemic BSG-P under a simulated gastrointestinal digestion,and the bioavailability of microencapsulated BSG-P using a rodent model of hyperlipidemia and other metabolic-related disorders induced by the consumption of a high-sucrose *** vitro studies showed that microencapsulation improved the BSG-P reduced hypolipidemic activity observed under a simulated gastrointestinal digestion by increasing the inhibition of the fat digestion enzymes,pancreatic lipase and cholesterol ***,in vivo studies demonstrated that microencapsulated BSG-P were also able to reduce the increased serum lipid levels(triglycerides-TG-cholesterol and free fatty acids),energy intake,visceral adipocytes size and TG content observed in sucrose-rich diet-fed *** was accompanied by reduced liver lipids levels and the activities of key enzymes involved in dietary fat ***,our findings show that microencapsulation is a useful strategy to preserve the hypolipidemic activity of BSG-P and support the concept that microencapsulated BSG-P would be an interesting and cheaper natural source to prevent hyperlipidemias and its related-disorders.

关键词： Bioactive peptides Brewer’s spent grain Hyperlipidemia Sucrose-rich diet metabolic tissue Digestive enzymes

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