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Could metabolic Risk factors Affect the Severity of Knee Osteoarthritis in Type-2 Diabetes Mellitus Patients? A Cross-Sectional Study

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Open Journal of Preventive Medicine 2022年第10期12卷 213-222页

作者： Mahmoud Reza Rahimi Barghani Noushin Khalili Mansour Salesi Azin Shayganfar Sarvenaz Rahimibarghani Endocrinology Department Isfahan University of Medical Sciences Isfahan Iran Rheumatology Department Isfahan University of Medical Sciences Isfahan Iran Radiology Department Isfahan University of Medical Sciences Isfahan Iran Physical Medicine and Rehabilitation Department Tehran University of Medical Sciences Tehran Iran

Introduction: Osteoarthritis (OA) is a common joint disease with varying degrees of severity. Patients with type-2 diabetes mellitus (T2DM) demonstrate a higher prevalence of OA, and several mechanisms have been proposed to explain the severity of OA in DM. In this study, we aimed to explore the effect of metabolic risk factors on the severity of knee OA in T2DM patients. Methods: This cross-sectional study was conducted in 2018 and included 57 patients with T2DM. Data were collected in terms of demographic variables and metabolic tests. After obtaining a medical history and examination, anteroposterior (AP) and lateral radiographs of both knees were taken, and the severity of OA was classified using the Kellgren-Lawrence (KL) classification system and categorized into two groups. Group A demonstrated patients with mild OA equivalent to grade 1 or 2 KL and group B showed moderate to severe OA (grade 3 or 4 KL). Results: A total of 57 patients with T2DM enrolled in the study, of which 32 patients exhibited grade 1 or 2 KL (group A) and 25 with grade 3 or 4 KL (group B). The mean age and mean body mass index (BMI) were higher in group B compared to group A, and the differences were statistically significant (P-value = 0.01). As with the other metabolic tests, the mean serum hemoglobin A1C (HbA1c) level was not statistically significant (P-value = 0.34). Conclusion: The data revealed that metabolic factors play a minor role in the severity of OA in patients with DM and that these changes are primarily influenced by increasing BMI and age.

关键词： Osteoarthritis Severity Diabetes metabolic factors

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metabolic aspects of hepatitis C virus

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World Journal of Gastroenterology 2022年第22期28卷 2429-2436页

作者： Mohamed El-Kassas Abeer Awad Department of Endemic Medicine Faculty of MedicineHelwan UniversityCairo 11795Egypt Department of Internal Medicine Faculty of MedicineCairo UniversityCairo 11566Egypt

Many metabolic factors are associated with chronic hepatitis C virus(HCV)infection and can influence the course of the illness and impact the progression of liver and non-liver-related diseases through complex *** of these factors impact the course of chronic HCV(CHC)and result in the conceptual translation of CHC from a localized to systemic *** the traditional liver manifestations associated with CHC infection,such as cirrhosis and hepatocellular carcinoma,various extrahepatic disorders are associated with HCV infection,including atherosclerosis,glucose and lipid metabolic disturbances,alterations in the iron metabolic pathways,and lymphoproliferative *** coexistence of metabolic disorders and CHC is known to influence the chronicity and virulence of HCV and accelerates the progression to liver fibrosis and hepatocellular *** resistance is one of the key factors that have a tremendous metabolic impact on ***,there is a great need to properly evaluate patients with CHC infection and correct the modifiable metabolic risk ***,patients with HCV who achieved a sustained virological response showed an overall improvement in glucose metabolism,but the exact evidence still requires further studies with long-term *** review delineates the most recent evidence on the main metabolic factors associated with CHC and the possible influence of chronic HCV infection on metabolic features.

关键词： Hepatitis C virus metabolic factors Steatosis Insulin resistance

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Mast Cells:The Key to Multiple Sclerosis?

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World Journal of Neuroscience 2014年第2期4卷 120-124页

作者： Per Goran Krüger Institute of Biomedicine University of BergenBergenNorway

Mast cells are present in high numbers in the border-zones of the multiple sclerosis-plaques. They are located in small clusters along capillaries and venules, and they are more abundant in females than in men. Mast cells can be stimulated to release specific mediators such as histamine, resulting in oedema formation, as well as proteases that may cause demyelination, by several different activation mechanisms. We hypothesize that a putative mast cell activation may be induced by diet factor(s) as well as long lasting mental stress that may lead to the release of catestatin, as well as ACTH released from the pituitary gland. Given a natural flux of mast cell recovery and activation, a putative phenomenon of massive release of mediators and “silent” reload periods may explain the relapsing-remitting phases of multiple sclerosis.

关键词： Multiple Sclerosis Mast Cells Histamine Mast Cell Proteases Socio-Cultural factors metabolic factors Mental Stress Catestatin Phtalates Female Male Relapsing-Remitting

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