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metabolic complications of psychotropic medications in psychiatric disorders:Emerging role of de novo lipogenesis and therapeutic consideration

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World Journal of Psychiatry 2024年第6期14卷 767-783页

作者： Mohammad M Khan Zaw Ali Khan Mohsin Ali Khan Laboratory of Translational Neurology and Molecular Psychiatry Department of BiotechnologyEra’s Lucknow Medical College and Hospitaland Faculty of ScienceEra UniversityLucknow 226003India Era’s Lucknow Medical College and Hospital Era UniversityLucknow 226003India

Although significant advances have been made in understanding the pathophysiology of psychiatric disorders(PDs),therapeutic advances have not been very *** psychotropic medications can reduce classical symptoms in patients with PDs,their long-term use has been reported to induce or exaggerate various pre-existing metabolic abnormalities including diabetes,obesity and non-alcoholic fatty liver disease(NAFLD).The mechanism(s)underlying these metabolic abnormalities is not clear;however,lipid/fatty acid accumulation due to enhanced de novo lipogenesis(DNL)has been shown to reduce membrane fluidity,increase oxidative stress and inflammation leading to the development of the aforementioned metabolic ***,emerging evidence suggest that DNL dysregulation and fatty acid accumulation could be the major mechanisms associated with the development of obesity,diabetes and NAFLD after long-term treatment with psychotropic medications in patients with *** support of this,several adjunctive drugs comprising of anti-oxidants and antiinflammatory agents,that are used in treating PDs in combination with psychotropic medications,have been shown to reduce insulin resistance and development of *** conclusion,the above evidence suggests that DNL could be a potential pathological factor associated with various metabolic abnormalities,and a new avenue for translational research and therapeutic drug designing in PDs.

关键词： Psychotropic medications metabolic complications De novo lipogenesis Obesity Diabetes Non-alcoholic fatty liver disease

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Clinical Food Addiction Is Not Associated with Development of metabolic complications in Liver Transplant Recipients

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Journal of Clinical and Translational Hepatology 2017年第4期5卷 335-342页

作者： Sammy Saab Cameron Sikavi Melissa Jimenez Matthew Viramontes Ruby Allen Youssef Challita Michelle Mai Negin Esmailzadeh Jonathan Grotts Gina Choi Francisco Durazo Mohamed El-Kabany Steven-Huy Han Elisa Moreno Departments of Medicine the University of California at Los AngelesLos AngelesCAUSA Departments of Surgery the University of California at Los AngelesLos AngelesCAUSA Departments of Psychiatry the University of California at Los AngelesLos AngelesCAUSA

Background and Aims:Given the increased risk of posttransplant metabolic syndrome(PTMS;defined by hypertension,diabetes mellitus and hyperlipidemia),we aimed to identify the potential role of food addiction in the development of metabolic complications in the post-liver transplant ***:Inclusion criteria included adult liver transplant recipients followed at our institution between June 2016 and November *** were administered a demographic survey as well as the Yale Food Assessment Scale 2.0,a 35-item questionnaire used to assess frequency of food addiction in accordance with the DSM-V guidelines of substance use *** and clinical data were ***:Our study included 236 liver transplant recipients(139 males,97 females).The median(interquartile range[IQR])BMI of participants was 26.8 kg/m2(24.2,30.4),and median(IQR)time since transplantation was 50.9 months(19.6,119.8).The prevalence rates of hypertension,hypercholesterolemia and diabetes mellitus were 54.7%,25.0%and 27.1%,*** participants(5.1%)were found to have a diagnosis of food addiction.A diagnosis of food misuse was made in 94(39.8%)of the transplant ***:Our findings are consistent with prior data that indicate high prevalence of metabolic complications among liver transplant *** addiction was not predictive of metabolic complications within this ***,we found that this population was at high risk of demonstrating symptoms of food misuse,and they were not likely to appreciate the risks of pathologic patterns of *** the increasing risk of cardiovascular morbidity and mortality in this population,efforts should be made to identify risk factors for the development of PTMS.

关键词： Food addiction Liver transplant metabolic complications

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