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Implications of metabolic dysfunction associated fatty liver disease in COVID-19

World Journal of Clinical Cases 2023年第6期11卷 1275-1286页

作者： Raja Chakraborty Deepak Sharma Devesh U Kapoor Akanksha Dwivedi Rakhi Khabiya Saikat Sen Institute of Pharmacy Assam Don Bosco UniversityGuwahati 782402AssamIndia School of Medical Sciences Adamas UniversityKolkata 700126West BengalIndia Department of Pharmacy Dr.Dayaram Patel Pharmacy CollegeBardoli 394601GujaratIndia Department of Pharmacy Acropolis Institute of Pharmaceutical Education&ResearchIndore 453771Madhya PradeshIndia Faculty of Pharmaceutical Science Assam down town UniversityGuwahati 781026AssamIndia

metabolic associated fatty liver disorder(MAFLD)characterizes the contributing etiologies(i.e.,type 2 diabetes mellitus,metabolic syndrome,overweight)of individuals with fatty liver disease that affects 1/3rd of the world *** 2020,the coronavirus disease 2019(COVID-19)crisis was unprecedented,and people with different comorbidities became more susceptible to the infection caused by severe acute respiratory syndrome coronavirus *** patients are frequently obese with added metabolic menace like diabetes,hypertension,and dyslipidemia leading to greater jeopardy of *** patients are 4 to 6-fold more prone towards ***-19 induces liver injury with elevated levels of aspartate aminotransferase and alanine aminotransferase and insignificantly elevated ***,MAFLD in COVID-19 patients worsens the condition *** evidence highlighting the interaction between MAFLD and altered liver functioning in COVID-19 suggested that COVID-19 patients with pre-existing MAFLD are at greater risk of morbidity or intensive care unit *** hepatic injury,enhanced levels of inflammatory cytokines,declined hepatic mitochondrial activity,and compromised immunity are considered as some underlying *** main focus of this review is to discuss the implications of metabolic dysfunction associated with fatty liver disease in COVID-19 *** review systematically analyzes the effect of striking two worldwide pandemics(MAFLD and COVID-19)together in the present era.

关键词： metabolic associated fatty liver disorder COVID-19 metabolic dysfunction Hepatic damage Cytokine storm

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