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Male and Female Hypogonadisms: Etiological, metabolic and Osteodensitometric Aspects

Open Journal of Endocrine and metabolic Diseases 2024年第2期14卷 39-52页

作者： Nestor Ghislain Andzouana Mbamognoua Ikram Damoune Sana Doubi Asmae Lahlou Farida Ajdi Department of metabolic and Endocrine Diseases Brazzaville University Hospital Brazzaville Republic of the Congo Faculty of Health Sciences Marien Ngouabi University Brazzaville Republic of Congo Department of Endocrinology Metabolic Diseases Hassan II University Hospital of Fez Fez Morocco

Introduction: Studies showed a high prevalence of metabolic abnormalities including dyslipidemia, type 2 diabetes in cases of low testosterone in men and which are associated with increased cardiovascular risk. Hypogonadism represents the second cause of endocrine osteoporosis. Objectives: The objectives of our work were: to determine the main causes of hypogonadism in women and men;to assess the frequency of metabolic and osteosdensitometric abnormalities in the hypogonadal population. Patients and methods: A retrospective descriptive study was carried out over 7 years on 120 patients, hospitalized in the Endocrinology department of the Hassan II University Hospital of Fez-Morocco for hypogonadism. The patients selected were those who had symptoms of hypogonadism confirmed in men by: low total testosterone for Tanner stage in adolescents, ng/ml or lower limit of normal for adults;in women, hypoestrogenia 30 pg/l. Gonadotropin dosage, karyotype, pelvic or testicular ultrasound and pituitary MRI, for etiological diagnosis, were performed. Bone densitometry was performed for bone impact and lipid profile for metabolic profile. Results: Out of 120 patients, there were 77 women and 43 men. The average age was 31.51 years. In men, the main causes were central hypogonadism in 67.4% and primary testicular failure in 32.6%. In women, central hypogonadism was also the most common cause noted in 63.7% and premature ovarian failure was observed in 36.4%. HypoHDL was significantly more frequent p (0.005) in women, osteopenia and osteoporosis were significantly more frequent in women than in men p (0.046). Conclusion: Central causes represent the most common etiology of hypogonadism in both sexes;abnormalities of bone mineralization and metabolic disorders were predominant in women.

关键词： Hypogonadism Etiological metabolic Osteodensitometric Fez

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metabolic phenotyping in health and disease

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四川生理科学杂志 2024年第4期46卷 908-908页

作者： Elaine Holmes 不详

Analyzing metabolites(small molecules<1 kDa)in body fluids such as urine and plasma using various spectroscopic methods provides information on the metabotype(metabolic phenotype)of individuals or populations,informat... 详细信息

Analyzing metabolites(small moleculesmetabolic phenotype)of individuals or populations,information that can be applied to personalized medicine or public healthcare.

关键词： urine metabolic body

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metabolic regulation of innate immunity in cancer immunotherapy

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Cancer Biology & Medicine 2023年第12期20卷 898-902页

作者： Yuheng Liao Hui Yang Department of Neurosurgery Huashan HospitalShanghai Key Laboratory of Medical EpigeneticsInternational Co-laboratory of Medical Epigenetics and Metabolism(Ministry of Science and Technology)and Molecular and Cell Biology LabInstitutes of Biomedical SciencesInstitute for Translational Brain ResearchShanghai Medical College of Fudan UniversityShanghai 200032China Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration Shanghai Clinical Medical Center of NeurosurgeryNeurosurgical Institute of Fudan UniversityHuashan HospitalShanghai Medical CollegeFudan UniversityShanghai 200032China State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science and MOE Frontiers Center for Brain Science Institutes of Brain ScienceShanghai Medical CollegeFudan UniversityShanghai 200032China

Innate immunity,originally recognized as the primary defense mechanism against pathogenic infections,has also been shown to have an important role in anti-tumor *** cells recognize cytosolic DNA and RNA,which triggers a cascade of signaling events via nucleic-acid sensing receptors,including endosomal Toll-like receptors(TLRs),cytoplasmic cyclic GMP-AMP synthase(cGAS)for double-stranded DNA sensing,and cytoplasmic retinoic acid-inducible gene I(RIG-I)for double-stranded RNA detection.

关键词： immunity immunotherapy metabolic

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Unlocking Cellular Mysteries:Advancements in Single-Cell Omics Analysis with Genome-Scale metabolic Modeling

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Bulletin of the Chinese Academy of Sciences 2024年第1期38卷 52-52页

The widespread applications of single-cell technologies have generated a large amount of single-cell data,resulting in a growing need for single-cell data analysis and interpretation *** methods such as machine learni... 详细信息

关键词： methods. metabolic locking

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Unveiling plant defense arsenal: metabolic strategies in Brassica oleracea during black rot disease

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Horticulture Research 2023年第11期10卷 120-130页

作者： Carmen Vega-Álvarez Pilar Soengas Thomas Roitsch Rosaura Abilleira Pablo Velasco Marta Francisco Group of Genetics Breeding and Biochemistry of BrassicasMisión Biológica de Galicia(CSIC)ES-36143PontevedraSpain Department of Plant and Environmental Sciences Copenhagen Plant Science CentreUniversity of CopenhagenDK-2630TaastrupDenmark

Alterations in plant metabolism play a key role in the complex plant-pathogen ***,there is still a lack of knowledge about the connection between changes in primary and specialized metabolism and the plant defense against diseases that impact ***,we aim to study the metabolic reprograming in Brassica oleracea plants upon infection by Xanthomonas campestris ***(Xcc).To accomplish this,we utilized a combination of untargeted and targeted metabolomics,through UPLC-Q-TOF-MS/MS and 1H-NMR,in two crop lines differing in resistance thatwere evaluated at two-and four-week intervals following inoculation(T1 and T2,respectively).Besides,to depict the physiological status of the plant during infection,enzymatic activities related to the carbohydrate pathway and oxidative stress were *** results revealed different temporal dynamics in the responses of the susceptible *** crops *** *** line suppresses carbohydrate metabolism contributing to limit nutrient supplies to the bacterium and prioritizes the induction of defensive compounds such as indolic glucosinolates,salicylic acid,phenylpropanoids and phytoalexins precursors at early infection *** contrast,the susceptible line invests in carbohydratemetabolism,including enzymatic activities related to the hexoses turnover,and activates defense signaling related to reactive oxygen ***,each line triggers a different metabolic strategy that will affect how the plant overcomes the disease in terms of resistance and *** work provides first insights of a fine-tuned metabolic regulation during Xcc infection in *** that will contribute to develop new strategies for plant disease management.

关键词： metabolic metabolism black

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Promoter replacement of ANT1 induces anthocyanin accumulation and triggers the shade avoidance response through developmental, physiological and metabolic reprogramming in tomato

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Horticulture Research 2023年第2期10卷 28-40页

作者： João Victor Abreu Cerqueira Feng Zhu Karoline Mendes Adriano Nunes-Nesi Samuel Cordeiro Vitor Martins Vagner Benedito Alisdair RFernie Agustin Zsögön Departamento de Biologia Vegetal Universidade Federal de ViçosaViçosa 36570-900 MGBrazil National R&D Center for Citrus Preservation Key Laboratory of Horticultural Plant BiologyMinistry of EducationHuazhong Agricultural University430070 WuhanChina Max-Planck-Institute for Molecular Plant Physiology 14476 PotsdamGermany Division of Plant&Soil Sciences West Virginia UniversityMorgantownWV 26506USA

The accumulation of anthocyanins is a well-known response to abiotic stresses in many plant ***,the effects of anthocyanin accumulation on light absorbance and photosynthesis are ***,we addressed this question using a promoter replacement line of tomato constitutively expressing a MYB transcription factor(ANTHOCYANIN1,ANT1)that leads to anthocyanin ***1-overexpressing plants displayed traits associated with shade avoidance response:thinner leaves,lower seed germination rate,suppressed side branching,increased chlorophyll concentration,and lower photosynthesis rates than the wild ***-rich leaves exhibited higher absorbance of light in the blue and red ends of the spectrum,while higher anthocyanin content in leaves provided photoprotection to high *** of gene expression and primary metabolites content showed that anthocyanin accumulation produces a reconfiguration of transcriptional and metabolic networks that is consistent with,but not identical to those described for the shade avoidance *** results provide novel insights about howanthocyanins accumulation affects the trade-off between photoprotection and growth.

关键词： metabolic expressing programming

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Investigation of prodromal features in metabolic syndrome based on transcriptome analysis

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Genes & Diseases 2023年第3期10卷 708-711页

作者： Sang-Min Park Musun Park Hyo-Jeong Ban Su-Jin Baek Soo Yeon Kim Siwoo Lee Hee-Jeong Jin Korean Medicine(KM)Data Division Korea Institute of Oriental MedicineDaejeon 34054Republic of Korea College of Pharmacy Chungnam National UniversityDaejeon 34134Republic of Korea

metabolic syndrome(MetS)is a complex condition that significantly increases the risk of several diseases,including heart disease and *** with MetS show both pro-inflammatory and pro-thrombotic states;however,the state... 详细信息

关键词： diseases metabolic Patients

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Association of Residential Greenness with the Prevalence of metabolic Syndrome in a Rural Chinese Population:the Henan Rural Cohort Study

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Biomedical and Environmental Sciences 2022年第1期35卷 89-94页

作者： HE Ya Ling LIU Xiao Tian TU Run Qi PAN Ming Ming NIU Miao Miao CHEN Gong Bo HOU Jian MAO Zhen Xing HUO Wen Qian LI Shan Shan GUO Yu Ming WANG Chong Jian Department of Epidemiology and Biostatistics College of Public HealthZhengzhou UniversityZhengzhou 450001HenanChina Guangdong Provincial Engineering Technology Research Center of Environmental and Health risk Assessment Department of Occupational and Environmental HealthSchool of Public HealthSun Yat-sen UniversityGuangzhou 510080GuangdongChina Department of Epidemiology and Preventive Medicine School of Public Health and Preventive MedicineMonash UniversityMelbourne 3004Australia

metabolic syndrome(MetS),a cluster of modifiable metabolic conditions(including abdominal obesity,dyslipidemia,elevated blood pressure,and hyperglycemia),has become an essential contributor to the global health burden... 详细信息

关键词： metabolic elevated Rural

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metabolic-associated fatty liver disease from childhood to adulthood:State of art and future directions

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World Journal of Hepatology 2022年第6期14卷 1087-1098页

作者： Francesca Lanzaro Stefano Guarino Elisabetta D'Addio Alessandra Salvatori JosèAlberto D'Anna Pierluigi Marzuillo Emanuele Miraglia del Giudice Anna Di Sessa Department of Woman Childand General and Specialized SurgeryUniversity of Campania“Luigi Vanvitelli”Naples 80138Italy

In 2020,an international group of experts proposed to replace the term of nonalcoholic fatty liver disease with metabolic-associated fatty liver disease(MAFLD).This recent proposal reflects the close association of fatty liver with metabolic derangements,as demonstrated by previous robust *** factors[including genetics,inflammation,metabolic abnormalities,insulin resistance(IR),obesity,prenatal determinants,and gut–liver axis]have been found to be involved in MAFLD pathophysiology,but this tangled puzzle remains to be clearly *** particular,IR has been recognized as a key player in metabolic impairments development in children with fatty *** this ground,MAFLD definition focuses on the pathophysiological basis of the disease,by emphasizing the crucial role of metabolic impairments in this *** primarily developed for adults,MAFLD diagnostic criteria have been recently updated with an age-appropriate definition for sex and age percentiles,because of the increasing attention to cardiometabolic risk in *** date,accumulating evidence is available on the feasibility of MAFLD definition in clinical practice,but some data are still conflicting in highly selected *** the growing prevalence worldwide of fatty liver and its close relationship with metabolic dysfunction both in children and adults with subsequent increased cardiovascular risk,early strategies for MAFLD identification,treatment and prevention are *** therapeutic insights for MAFLD based on promising innovative biological techniques are also *** aimed to summarize the most recent evidence in this intriguing research area both in children and adults.

关键词： metabolic dysfunction Fatty Liver Pathophysiology Cardiovascular Risk Adults Children

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Prevalence of metabolic Syndrome and Risk Factors Among Chinese Adults:Results from a Population-Based Study—Beijing,China,2017–2018

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China CDC weekly 2022年第29期4卷 640-645页

作者： Jufen Liu Qingping Liu Zhiwen Li Jing Du Chao Wang Yanlin Gao Zaihua Wei Jing Wang Yunping Shi Jianting Su Yang Liu Ping Wang Chunyan Xie Gang Li Bing Shao Le Zhang Institute of Reproductive and Child Health/Key Laboratory of Reproductive Health National Health Commission of the People’s Republic of ChinaPeking UniversityBeijingChina Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijingChina Department of Information and Statistics Beijing Center for Disease Prevention and ControlBeijingChina Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning B

Summary What is already known about this topic?metabolic syndrome(MetS)is one of the most easily available health indicative markers for cardiovascular diseases,and it has become a major public health problem worldwide due to increasing urbanization and aging *** prevalence of MetS increased dramatically in China,however,there are no records of MetS defined by the 2017 Chinese Diabetes Society for Beijing by *** is added by this report?In this study,the data of 24,412 participants aged 18–74 years from a large population-based study in Beijing was *** overall prevalence of MetS among Beijing residents was 24.5%.The prevalence was 35.2%in males and 15.4%in *** are the implications for public health practice?Effective public health strategies should target males,people with older age,lower education,higher body mass index,smokers,those who drink alcohol,those who are unemployed or retired,and those who live in rural areas on MetS prevention and control.

关键词： metabolic prevention smoke

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