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Exercise interventions for older adults: A systematic review of meta-analyses

Journal of Sport and Health Science 2021年第1期10卷 29-47,I0001页

作者： Claudio Di Lorito Annabelle Long Adrian Byrne Rowan H.Harwood John R.F.Gladman Stefan Schneider Pip Logan Alessandro Bosco Veronika van der Wardt Division of Rehabilitation Ageingand WellbeingSchool of MedicineUniversity of NottinghamNottingham NG72UHUK Division of Health Sciences School of MedicineUniversity of NottinghamNottingham NG72UHUK Institute of Movement and Neurosciences German Sport UniversityCologne 50933Germany Division of Psychiatry and Applied Psychology School of MedicineUniversity of NottinghamNottingham NG72UHUK Center for Methodology and Health Research Department of General MedicinePreventive and Rehabilitative MedicinePhilipps-Universität MarburgMarburg 35032Germany

Background:The evidence concerning which physical exercise characteristics are most effective for older adults is *** aimed to characterize the extent of this diversity and inconsistency and identify future directions for research by undertaking a systematic review of metaanalyses of exercise interventions in older ***:We searched the Cochrane Database of Systematic Reviews,PsycInfo,MEDLINE,Embase,CINAHL,AMED,SPORTDiscus,and Web of Science for articles that met the following criteria:(1)meta-analyses that synthesized measures of improvement(e.g.,effect sizes)on any outcome identified in studies of exercise interventions;(2)participants in the studies meta-analyzed were adults aged 65+or had a mean age of 70+;(3)meta-analyses that included studies of any type of exercise,including its duration,frequency,intensity,and mode of delivery;(4)interventions that included multiple components(e.g.,exercise and cognitive stimulation),with effect sizes that were computed separately for the exercise component;and(5)meta-analyses that were published in any year or *** characteristics of the reviews,of the interventions,and of the parameters improved through exercise were reported through narrative *** of the interventions linked to the largest improvements was carried out by identifying the highest values for improvement recorded across the *** study included 56 meta-analyses that were heterogeneous in relation to population,sample size,settings,outcomes,and intervention ***:The largest effect sizes for improvement were found for resistance training,meditative movement interventions,and exercise-based active ***:The review identified important gaps in research,including a lack of studies investigating the benefits of group interventions,the characteristics of professionals delivering the interventions associated with better outcomes,and the impact of motivational strategies and of sig

关键词： Intervention meta-analyses Old Physical exercise Systematic review

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Pollutant exposure and health outcomes:protocol for a comprehensive umbrella review of meta-analyses and evidence mapping

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Asian Toxicology Research 2021年第3期3卷 12-17页

作者： Jing Qi Lufang Feng Jiemei Hu Haitong Zhao Jieyun Li Lixin Ke Xue Shang Kehu Yang Cuncun Lu Gansu Provincial Hospital Lanzhou 730000China School of Public Health Lanzhou UniversityLanzhou 730000China School of Basic Medical Sciences Lanzhou UniversityLanzhou 730000China The First Affiliated Hospital Sun Yat-sen UniversityGuangzhou 510080China

Background:Many systematic reviews and meta-analyses(MAs)regarding the association between pollutant(e.g.,air pollution,noise pollution,and heavy metal pollution)exposure and health outcomes have been published recently,but there is still a lack of comprehensive research based on these MAs,and the evidence quality of these MAs are ***,we designed an umbrella review to address these gaps in ***:MAs that evaluated the association between pollutant exposure and health outcomes will be systematically searched through the PubMed and Embase databases in May *** of reviewers will conduct the study screening and data extraction independently,and cross-check the *** and AMSTAR 2 will be used to evaluate the reporting and methodological quality of MAs included,respectively,and an evidence mapping method will be used to present the *** corrected cover area(CCA)method will be used to assess the degree of overlap for included primary studies among *** outcomes will be reanalyzed based on the random-effects model using the appropriate effect size,and the corresponding 95%confidence intervals will be ***,sensitivity analysis and subgroup analysis will be used to explore *** GRADE method will be used to evaluate the evidence quality of outcome *** 16.0 and Excel 2019 will be used for data analysis,and P<0.05 will be considered to indicate statistical ***:The results of this umbrella review will be submitted to a peer-reviewed English journal for ***:We designed the first umbrella review to summarize evidence from MAs on the association between common pollutant exposure and health *** results of this study will provide evidence for health policy makers to formulate appropriate health policies and researchers to conduct new studies.

关键词： Air pollution Noise Heavy metal Umbrella review meta-analyses

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Treatment of Atherosclerotic Disease of the Femoral Artery: Randomized Controlled Trials and meta-analyses. Should You Be Sceptical?

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Surgical Science 2019年第7期10卷 235-254页

作者： Raymond Englund St George Private Hospital Kogarah Sydney

A narrative review of the data provided by Randomised Controlled clinical trials and meta-analyses was undertaken to assess how much reliance a clinician could place on these in selecting a treatment for patients with disease of the Femoral artery. An attempt was made to detect and review every clinical trial and meta-analysis published on treatments relating to disease of the femoral artery but not relating to drug treatment. Disease of the femoral artery in >65 years age group occurs in approximately 20% of the population but symptomatology was present in 40%. In almost all trials the predominant (>90%) indication for treatment was intermittent claudication. In this setting, clinical benefit was limited and did not extend beyond 12 months. Mortality, from co-morbidities was high. The Basil Trial was the only one to examine intervention for critical limb ischemia. The results for Bypass surgery and Percutaneous transarterial balloon angioplasty (PTA) were equivalent. There is little evidence to support the use of PTA or stenting other than in the treatment of patients with critical limb ischemia.

关键词： Femoral Artery Stent (Nitinol Drug-Eluting Covered) Percutaneous Balloon Angioplasty Drug Eluting Balloons Randomised Controlled Trials meta-analyses Intermittent Claudication Critical Limb Ischemia Patency Clinical Benefit

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Systematic reviews and meta-analyses: Why are they clinically significant?

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World Journal of meta-Analysis 2015年第3期3卷 139-141页

作者： Xing-Shun Qi Zhi-Ping Yang Ming Bai Yong-Ji Wang Evidence-Based Medicine Group Xijing Hospital of Digestive Diseases Fourth Military Medical University Department of Gastroenterology General Hospital of Shenyang Military Area Department of Nephrology Xijing Hospital Fourth Military Medical University Medical Department 309th Hospital of Chinese People’s Liberation Army Department of Health Statistics Fourth Military Medical University

This review aims to clarify the clinical significance of systematic reviews and meta-analyses by illustrating several classical ***,systematic reviews can provide the highest level of evidence for clinical ***,systematic reviews can propose unresolved issues and future ***,systematic reviews can avoid harm to the human ***,systematic reviews can prevent a waste of *** speaking,clinical researchers should be encouraged to perform systematic reviews and metaanalyses.

关键词： Systematic reviews meta-analyses China Publication Science citation index

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Current systematic reviews and meta-analyses of COVID-19

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World Journal of Virology 2021年第4期10卷 182-208页

作者： Mahmoud Nassar Nso Nso Mostafa Alfishawy Anastasia Novikov Salim Yaghi Luis Medina Bahtiyar Toz Sofia Lakhdar Zarwa Idrees Yungmin Kim Dawa Ongyal Gurung Raheel S Siddiqui David Zheng Mariam Agladze Vikram Sumbly Jasmine Sandhu Francisco Cuevas Castillo Nadya Chowdhury Ravali Kondaveeti Sakil Bhuiyan Laura Guzman Perez Riki Ranat Carlos Gonzalez Harangad Bhangoo John Williams Alaa Eldin Osman Joyce Kong Jonathan Ariyaratnam Mahmoud Mohamed Ismail Omran Mariely Lopez Akwe Nyabera Ian Landry Saba Iqbal Anoosh Zafar Gondal Sameen Hassan Ahmed Daoud Bahaaeldin Baraka Theo Trandafirescu Vincent Rizzo Department of Internal Medicine Icahn School of Medicine at Mount Sinai/NYC H&H QueensNew YorkNY 11432United States Department of Infectious Diseases Infectious Diseases Consultants and Academic Researchers of Egypt(IDCARE)Cairo 11221Outside of the USEgypt Department of Medicine Division of NephrologyUniversity of Tennessee Health Science CenterKnoxville CityTN 38103United States Department of Medical St.George's UniversityWest Indies 38901Grenada Department of Internal Medicine Faculty of MedicineCairo UniversityCairo 11221Egypt Department of Oncology Broomfiled HospitalMid and South Essex NHS Foundation TrustESSEXChelmsford 12422United Kingdom Department of Critical Care Unit Icahn School of Medicine at Mount Sinai/NYC H&H QueensNew YorkNY 11432United States

BACKGROUND Coronavirus disease 2019(COVID-19)has left a significant impact on the world's health,economic and political systems;as of November 20,2020,more than 57 million people have been infected worldwide,with over 1.3 million *** the global spotlight is currently focused on combating this pandemic through means ranging from finding a treatment among existing therapeutic agents to inventing a vaccine that can aid in halting the further loss of *** To collect all systematic reviews and meta-analyses published related to COVID-19 to better identify available evidence,highlight gaps in knowledge,and elucidate further meta-analyses and umbrella reviews that are yet to be *** We explored studies based on systematic reviews and meta-analyses with the keyterms,including severe acute respiratory syndrome(SARS),SARS virus,coronavirus disease,COVID-19,and SARS *** included studies were extracted from Embase,Medline,and Cochrane *** publication timeframe of included studies ranged between January 01,2020,to October 30,*** that were published in languages other than English were not considered for this systematic *** finalized full-text articles are freely accessible in the public *** Searching Embase,Medline,and Cochrane databases resulted in 1906,669,and 19 results,respectively,that comprised 2594 studies.515 duplicates were subsequently removed,leaving 2079 *** inclusion criteria were systematic reviews or meta-analyses.860 results were excluded for being a review article,scope review,rapid review,panel review,or guideline that produced a total of 1219 *** screening articles were categorized,the included articles were put into main groups of clinical presentation,epi-demiology,screening and diagnosis,severity assessment,special populations,and ***,there was a second subclassification into the following groups:gastrointestinal,cardiovascular,neurological,stro

关键词： Systematic review meta-analyses COVID-19 Review Coronavirinae

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Reporting quality evaluation of meta-analyses for cognitive interventions among Alzheimer's dementia

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TMR Aging 2020年第4期2卷 132-141页

作者： Guang-Hong Han Xiao-Li Pang Qi Wu Hui-Li Sun Wei Wang Graduate School Tianjin University of Traditional Chinese MedicineTianjinChina School of Nursing Tianjin University of Traditional Chinese MedicineTianjinChina

Background:To appraise the reporting quality of systematic reviews as well as meta-analyses of cognitive interventions among Alzheimer's disease using the PRISMA statement,and to investigate the related factors influencing the reporting ***:Web of Science,Pubmed,Embase,Medline,as well as Cochrane Library were searched to collect the systematic reviews as well as meta-analyses of cognitive interventions among Alzheimer's disease from inception to September 17th *** PRISMA statement was used to appraise their reporting quality and investigate the compliance with each PRISMA ***,the potential factors affecting the reporting quality were analyzed based on the univariate ***:Seventeen articles were *** mean compliance with the PRISMA statement was 74.86% and the standard deviation was *** univariate analysis indicated that the number of authors(P=0.019)might be a factor affecting the reporting ***,the journal impact factor(P=0.133),the number of studies included(P=0.170),the number of databases retrieved(P=0.201),funding report(P=0.228),and original studies(randomized controlled trials only)(P=0.322)might not affect the reporting ***:The overall reporting quality was high,but the compliance with the 11 PRISMA items,such as"structured summary"and"protocol and registration"was *** research should focus on adequate reporting of these items in the hope that readers will be better able to discern the accuracy and reliability of relevant information and make correct decisions.

关键词： Alzheimer’s disease Reporting quality Cognitive intervention meta-analyses PRISMA

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Methodological quality assessment of meta-analyses of cognitive interventions among Alzheimer's disease

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TMR Integrative Nursing 2021年第5期5卷 170-173页

作者： Guang-Hong Han Xiao-Li Pang Wei Wang Hui-Li Sun Graduate School Tianjin University of Traditional Chinese MedicineTianjin301617China School of Nursing Tianjin University of Traditional Chinese MedicineTianjin301617China

Aims:The current study is designed to assess the methodological quality of the meta-analyses of cognitive interventions among Alzheimer's disease,and to investigate the compliance with 16 AMSTAR 2 ***:We searched Web of Scie nce,Sino med,PubMed,Embase,and Cochra ne Library from 2016 to 2021,to get the meta-a nalyses of cog nitive in terve nti ons in Alzheimer's *** AMSTAR 2 was used to assess the methodological ***,we also explored the complia nce with *** ts:We in cluded 9 studies in our *** them,6 articles were rated as"extremely low",2 articles as"low"and 1 article as"high".Furthermore,the reporting rates for 16 AMSTAR 2 items ranged from 22.22%to 100%.Conclusion:The methodological quality of meta-analyses of cognitive interventions in Alzheimer's disease is not ideal,and there is still room for *** studies are supposed to explore the releva nt factors that possibly in flue nce the methodological quality.

关键词： Alzheimer's disease AMSTAR Methodological quality meta-analyses Cognitive interventions

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Effect of Na Fe EDTA-Fortified Soy Sauce on Anemia Prevalence in China: A Systematic Review and meta-analysis of Randomized Controlled Trials

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Biomedical and Environmental Sciences 2015年第11期28卷 788-798页

作者： HUO Jun Sheng YIN Ji Yong SUN Jing HUANG Jian LU Zhen Xin REGINA Moench-Pfanner CHEN Jun Shi CHEN Chun Ming Key Laboratory of trace element nutrition of Ministry of health National Institute for Nutrition and HealthChinese Center for Disease Control and Prevention Global Alliance of Improved Nutrition Singapore

Objective To assess the effect of sodium iron ethylenediaminetetraacetate （NaFeEDTA）-fortified soy sauce on anemia prevalence in the Chinese population. Methods A systematic review was performed to identify potential studies by searching the electronic databases of PubMed, Cochrane Library, WHO Library, HighWire, CNKI, and other sources. The selection criteria included randomized controlled trials that compared the efficacy of NaFeEDTA-fortified soy sauce with that of non-fortified soy sauce. Anemia rates and hemoglobin levels were the outcomes of interest. Inclusion decisions, quality assessment, and data extraction were performed by two reviewers independently. A total of 16 studies met the inclusion criteria for anemia rate analysis, of which 12 studies met the inclusion criteria for hemoglobin analysis. All included studies assessed the effect of NaFeEDTA-fortified soy sauce on anemia rates and hemoglobin concentrations. Results After the intervention, the hemoglobin concentration increased and anemia rates decreased significantly as compared with the non-fortified soy sauce groups. For anemia rates, data from 16 studies could be pooled, and the pooled estimate odds ratio was 0.25 （95% CI 0.19-0.35）. For hemoglobin concentrations, data from 12 studies could be pooled, and the pooled weighted mean difference was 8.81 g/L （95% CI 5.96-11.67）. Conclusion NaFeEDTA-fortified soy sauce has a positive effect on anemia control and prevention in the at-risk population.

关键词： Sodium iron ethylenediaminetetraacetate NaFeEDTA Anemia Hemoglobin Iron deficiency meta-analyses Food fortification

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Protein induced by vitamin K absence or antagonist-Ⅱ versus alpha-fetoprotein in the diagnosis of hepatocellular carcinoma: A systematic review with meta-analysis

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Hepatobiliary & Pancreatic Diseases International 2018年第6期17卷 487-495页

作者： Hao Xing Yi-Jie Zheng Jun Han Han Zhang Zhen-Li Li Wan-Yee Lau Feng Shen Tian Yang Department of Hepatic Surgery Eastern Hepatobiliary Surgery Hospital Naval Medical University Medical Scientific Affairs Abbott Diagnostics Faculty of Medicine The Chinese University of Hong Kong

Background: As a promising biomarker of hepatocellular carcinoma(HCC), protein induced by vitamin K absence or antagonist-Ⅱ(PIVKA-Ⅱ) has been studied extensively. However, its diagnostic capability varies across HCC studies. This study aimed to compare the performance of PIVKA-Ⅱ with alpha-fetoprotein(AFP) in the diagnosis of HCC. Data sources: A systematic literature search was conducted to identify the studies from MEDLINE, Embase and Cochrane Library Databases, which were published up to December 20, 2017 to compare the diagnostic capability of PIVKA-Ⅱ and AFP for HCC. The data were pooled using random effects model. Pooled sensitivity and specificity were calculated. Summary receiver operating characteristic curve(ROC) was employed to evaluate the diagnostic accuracy of each marker. Results: Thirty-one studies were included. The pooled sensitivity(95% CI) of PIVKA-Ⅱ and AFP was 0.66(0.65–0.68) and 0.66(0.65–0.67), respectively in diagnosis of HCC; and the corresponding pooled specificity(95% CI) was 0.89(0.88–0.90) and 0.84(0.83–0.85), respectively. The area under the ROC curve(AUC) of PIVKA-Ⅱ and AFP was 0.856(0.817–0.895) and 0.770(0.728–0.811), respectively. Subgroup analysis showed that PIVKA-Ⅱ was superior to AFP in terms of the AUC for both small HCC( meta-analysis indicates that PIVKA-Ⅱ is better than AFP in terms of the accuracy for diagnosing HCC, regardless of tumor size, patient ethnic group, or HCC etiology.

关键词： Hepatocellular carcinoma meta-analyses Protein induced by vitamin K absence or antagonist-Ⅱ Alpha-fetoprotein

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Liuwei Dihuang Pills(六味地黄丸) Enhance the Effect of Western Medicine in Treating Type 2 Diabetes:A meta-Analysis of Randomized Controlled Trials

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Chinese Journal of Integrative Medicine 2013年第10期19卷 783-791页

作者：濮润耿向楠于飞梁会刚史录文 Department of Pharmacy Administration and Clinical Pharmacy School of Pharmaceutical SciencesPeking University Health Science Center Chinese Pharmaceutical Association Peking University First Hospital Center for Healthcare Management Systems East Carolina UniversityNC(27858-4353)USA

Objective： To perform meta-analyses evaluating the efficacy of adding Liuwei Dihuang Pills （六味地黄丸 LDP） to Western medicine in improving treatment outcomes for type 2 diabetes. Methods： Medline, PubMed, Cochrane Library, and Chinese databases, including the Chinese National Knowledge Infrastructure were searched to identify eligible studies; i.e., if the study involved a randomized clinical trial in which the experimental group combined LDP with Western drugs and the control group used the corresponding Western drugs alone to treat type 2 diabetes. Outcomes were measured in terms of fasting blood glucose （FBG）, postprandial blood glucose （2hPG） and HbAlc level. Efficacy was also measured by using control and response rates. The combined odds ratio （OR）, mean difference （MD）, and 95% confidence intervals （95% CI） were calculated. Results： Studies included in the analysis were less adequate than expected in terms of methodological qualify. A total of 1,609 patients from 18 studies were included. We found that adding LDP can lower patients＇ FBG （MD=0.54 mmol/L, 95% CI [0.15, 0.93], P=0.007）, 2hPG （MD=1.05 mmol/L, 95% CI [0.29, 1.81], P〈0.01） and HbAlc （MD=0.23, 95% CI [0.02, 0.45], P=0.008）. There were also improvements in treatment response rates （OR=3.41, 95% CI [2.38, 4.90], P〈0.01） and control rates （OR=2.47, 95% CI [1.91, 3.20], P〈0.01）. Conclusion： Adding LDP to Western medicine might improve treatment outcomes of diabetes, including FBG, 2hPG, response rates and control rates.

关键词： meta-analyses Liuwei Dihuang Pills type 2 diabetes fasting blood glucose postprandial bloodglucose hemoglobin Alc

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