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Clinical Assessment of a mesotherapy Formulation for Skin Rejuvenation in Healthy Volunteers

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Journal of Cosmetics, Dermatological Sciences and Applications 2017年第4期7卷 291-305页

作者： Anne Grand-Vincent Sylvie Boisnic Catherine Salomon Pascal Prinderre Philippe Piccerelle Aesthetic Medecine Center Paris French Scientific Research and Assessment Group in Dermatology and Cosmetology (GREDECO) Paris French Filorga Laboratories Paris French Pharmaceutical Bioengineering Department Mediterranean Institute of Biodiversity and Marine Ecology Marseille French

mesotherapy is a mildly invasive procedure involving several subcutaneous drug injections, which are performed simultaneously. The concept is to inject a very small amount of active compounds (hyaluronic acid, vitamins, antioxidants, enzymes, humectants, …) and the aim is to stimulate the biosynthetic capacity of fibroblasts, increase collagen and elastin production and to give active essential molecules for a fibroblasts environment. Numerous studies suggest that the mesotherapy procedure improves skin hydration and mechanical properties;however, some results have not been statistically significant. In this study, we investigated an antiaging treatment as a complementary approach to a non-surgical rejuvenating procedure after 5 sessions of mesotherapy. Our main objective was to assess the improvement of face, neck and neckline skin quality, after intradermal microinjections of NCTF 135HA®. This mixture, manufactured by FILORGA Laboratories, includes a non-cross-linked hyaluronic acid, vitamins, antioxidants, mineral salts and enzymes. A statistically significant decrease in the depth of crow’s-feet wrinkles (43.3%) and in pore size (58.5%) was observed. Also, dermatological scores showed a significant decrease, and data suggest that skin tone was improved with a brighter tone. The injected mixture could then have an action on the skin pigmentation process with a photoprotective effect. Evolution of Dermis density was also investigated and an increase of dermal density and thickness were highlighted, showing an improvement of skin firmness with significant increases of dermis thickness (20%) and dermis density (24%), indicating a neocollagen activity.

关键词： mesotherapy Skin Rejuvenation Multi-Component Solution Crow’s-Feet Wrinkles Pore Size Dermis Density Dermis Thickness

Improvement of Atrophic Acne Scar and Skin Complexity by Combination of Aqueous Human Placenta Extract and Mesenchymal Stem Cell mesotherapy

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Journal of Cosmetics, Dermatological Sciences and Applications 2020年第1期10卷 1-7页

作者： Ruchee Phonchai Pimjai Naigowit Bunchob Ubonsaen Supansa Nilubol Supaluk Brameld Parinya Noisa Laboratory of Cell-Based Assay and Innovations Biotechnology Suranaree University of Technology Nakhon Ratchasima Thailand LBM Stem Cell Research Unit Life Balance Methodology Co. Ltd. Bangkok Thailand Sangkhom Hospital Nongkhai Provincial Health Office Nongkhai Thailand National Institute of Health Ministry of Public Health Nonthaburi Thailand

Atrophic scars, a permanent complication of severe acne, have negative effect on psychology in adolescent. The treatment of atrophic scar is depended on types of scar and it is difficult to improve by a single treatment. Mesenchymal stem cell is a scientific approval for surgery scar treatment and wound healing. We present a case report of female presented with atrophic acne scar distributed on both cheeks. The case aims to prove that the combination of MSCs and aqueous human placenta extract (RGF®) contained bioactive therapeutic molecules obviously promoted the improvement of skin scar to reach the optimal outcomes. We first found that MSCs-contained human placenta extract solution combination subcision improves the atrophic acne scar and skin complexity by enhancement of skin cell regeneration.

关键词： Atrophic Scar Mesenchymal Stem Cells Human Placenta Extract mesotherapy Skin Regeneration

Effectiveness of mesotherapy on Temporomandibular Joint Disorders

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Journal of Physical Science and Application 2015年第4期5卷 249-254页

作者： Andre Pedro Oliveira Cruz Ana Filipa Rodrigues das Neves Isabel Ramires Manuel Mendonca Servico de Medicina Fisica e de Reabilitacao Hospital de S. Jose Centro Hospitalar de Lisboa Central Lisboa 1150-199 Portugal

TMJDs （Temporomandibular joint disorders） are a common pathology but best treatment remains unclear. The goal of this study was to evaluate the effectiveness of mesotherapy on TMJD. We conducted a case review of all TMJD patients treated since 2006 with mesotherapy procedures only and using a cocktail of drugs composing of lidocaine, piroxicam and pentoxifylline. Patients were treated every 15 days until symptomatic relief was achieved and thereafter every two months. Main outcome was complete symptomatic relief, and associated factors were analysed. 27 patients were included. Complete pain relief was achieved in 26. The necessary number of procedures to get pain relief ranged from 1 to 6 （median of 1） and the total number of treatments from 1 to 40 （median of 11）. 19 patients had other painful complains mainly related with anxiety disorders. A weak correlation （r = 0.357; p = 0.05） between anxiety disorders and the required months of treatments was found. mesotherapy is a valuable option on pain relief in a temporomandibular pain syndrome with none of the systemic effects of oral medication. Anxiety may have a role on the aetiology and therapeutic success highlights the holistic approach of these patients. Future comparative studies are necessary.

关键词： TMJDs (Temporomandibular joint disorders) mesotherapy pain.

mesotherapy—中胚层疗法的药物及药物配方(Ⅲ)

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Mesotherapy—中胚层疗法的药物及药物配方(Ⅲ)

第4届中国美容与整形医师大会

作者：高景恒辽宁省人民医院

2006年4月,笔者首次发表了中胚层疗法(mesotherapy)——美容医学的新技术。该文复习了部分国际文献,描述了mesotherapy的发展历史背景,该项技术特征及其发展和未来研究的相关解剖——筋膜系统等。

关键词： mesotherapy 中胚层疗法药物配方美容医学脂肪减肥

基于mesotherapy的溶脂与提升技术试验研究

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基于Mesotherapy的溶脂与提升技术试验研究

2015年中国中西医结合医学美容学术会议、中国中西医结合学会医学美容专业委员会暨第三届中国中西医结合抗衰老微创技术研讨会、第四届全国乳房与形体整形美容高峰论坛、第十七届海峡两岸微整形学术研讨会

作者：苑丰

1952年,法国医生Michel Pistor用表皮注射的方式治疗耳疾,在病人的耳鸣得到改善的同时,却意外的发现外耳道的湿疹和颞下颌关节疼也得到了大大的改善。1958年,他发表文章详细描述了他的试验和治疗结果 ,并第一次将这种直接将药物注射到... 详细信息

1952年,法国医生Michel Pistor用表皮注射的方式治疗耳疾,在病人的耳鸣得到改善的同时,却意外的发现外耳道的湿疹和颞下颌关节疼也得到了大大的改善。1958年,他发表文章详细描述了他的试验和治疗结果 ,并第一次将这种直接将药物注射到皮肤表皮或中胚层的疗法称之为"mesotherapy",他写道"这种中胚层注射疗法对于所要治疗的组织(tissue)是如此的有效,我们应该称之为"mesotherapy",意即:"在正确的位置,注射小剂量的药物"。

关键词： mesotherapy 提升技术

关于mesotherapy——中胚层疗法的论述（Ⅱ）

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关于Mesotherapy——中胚层疗法的论述（Ⅱ）

第4届中国美容与整形医师大会

作者：高景恒辽宁省人民医院

＜正＞1无创美容技术的进展信息非创伤技术在美容外科的发展,是美容医学发展的需要,是医学科学发展的需要,是科学发展的自然客观规律,是患者安全利益的最终需要。非创伤技术包括:激光技术、光学技术、电、射频技术、超声技术、中胚层疗... 详细信息

＜正＞1无创美容技术的进展信息非创伤技术在美容外科的发展,是美容医学发展的需要,是医学科学发展的需要,是科学发展的自然客观规律,是患者安全利益的最终需要。非创伤技术包括:激光技术、光学技术、电、射频技术、超声技术、中胚层疗法（mesotherapy）等。

关键词： mesotherapy 中胚层疗法无创美容医学美容非创伤技术

History of mesotherapy——中胚层疗法的历史

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History of Mesotherapy——中胚层疗法的历史

第4届中国美容与整形医师大会

作者： Jaeques Le Coz 高景恒岳丽爽

＜正＞mesotherapy这个名词术语在1958年由Pisto Dr.提出,其前缀“Meso”常常提出某些问题。作者,它的治疗唯一有效是在中胚层发育的组织物,然而中胚层组织效果是如此重要的,这些治疗值得世界接受mesotherapy的这个名词（血管、肌腱和... 详细信息

＜正＞mesotherapy这个名词术语在1958年由Pisto Dr.提出,其前缀“Meso”常常提出某些问题。作者,它的治疗唯一有效是在中胚层发育的组织物,然而中胚层组织效果是如此重要的,这些治疗值得世界接受mesotherapy的这个名词（血管、肌腱和临界组织）。

关键词： mesotherapy 中胚层疗法中胚层组织皮肤病灶美容外科

关于“mesotherapy”词义及其汉译的商榷

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中国美容整形外科杂志 2009年第8期20卷 451-451页

作者：刘玮解放军空军总医院皮肤病研究所北京100036

“中胚层疗法”一词译自外文mesotherapy。近年来，在一些专业杂志和学术交流场合频频出现，其中经常被误解、误用。例如，有学者在进行学术演讲时，把针刺入皮下称之为“刺人中胚层”；还有人在描述皮肤的组织结构时，直接把真皮部分... 详细信息

“中胚层疗法”一词译自外文mesotherapy。近年来，在一些专业杂志和学术交流场合频频出现，其中经常被误解、误用。例如，有学者在进行学术演讲时，把针刺入皮下称之为“刺人中胚层”；还有人在描述皮肤的组织结构时，直接把真皮部分称之为“中胚层”等。这就混淆了一些基本的生物学概念。为此，笔者提出一点不同见解供读者参考。

关键词： mesotherapy 中胚层疗法美塑疗法

Research Progress of Hair Growth Technology

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China Detergent & Cosmetics 2021年第3期6卷 65-70页

作者： Zhang Jingjing Xia Liming Meng Xiangyan Shi Huizhe Guangzhou JNUMESO Biotechnology Co. Ltd.China

This summarizes the research progress of domestic and foreign experts on the methods and technologies of hair growth,including the hair growth effects of natural plant extracts,mesotherapy and stem cell *** forward to the development trend in the field of hair growth,mesotherapy has the advantages of convenient operation,good targeting,fewer side effects,and high cost *** it with anti-hair loss cosmetic products containing natural plant extracts to treat hair loss has very broad application prospects.

关键词： hair growth plant extracts mesotherapy stem cell therapy